Use of Optical Coherence Tomography in Myopia

Alm

2011

. Purpose: This study aimed to investigate normal values and interocular differences in retinal nerve fibre layer (RNFL) thickness, using optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT), in 5–16‐year‐old children born at full‐term with normal birthweights. Methods: Fifty‐six children with normal visual acuity and refraction were examined with Stratus OCT and HRT. Three examinations were performed in each eye. One eye in each child was randomized for analyses of normal values. Findings in 54 eyes were evaluated. Mean values of RNFL thickness were calculated. Coefficients of variance and intraclass correlations were calculated. The correlation between right and left eyes and the limits of difference were determined for both methods. Results: Mean RNFL thickness was 98.4 μm (standard deviation [SD] 7.88 μm) assessed with OCT and 213.0 μm (SD 54.0 μm) assessed with HRT. No correlations between age or gender and RNFL thickness were found. The coefficients of variance were 2.9% and 5.6% for OCT and HRT, respectively, and intraclass correlations were 0.85 and 0.88, respectively. The limits of difference between the two eyes ranged from −9 μm to 9 μm with OCT and from −109 μm to 87 μm with HRT. Conclusions: Both OCT and HRT can be used in children aged 5–16 years, but OCT provides less variability in determinations of RNFL thickness, both in repeated examinations of the same eye and in comparisons between the two eyes. The present study provides values for normal RNFL thickness in healthy children which can be used to make comparisons with values in children with optic nerve diseases.

Section: Discussionmentioning

confidence: 99%

Retinal nerve fibre layer thickness in full-term children assessed with Heidelberg retinal tomography and optical coherence tomography: normal values and interocular asymmetry

Larsson

Alm

2011

“…A general thinning of the inner and outer macular area was also detected in the children with albinism, but not in the three children with aniridia. An association between reduced macular thickness and myopia has been described (Mrugacz et al. 2004; Pierre‐Kahn et al.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography is helpful in the diagnosis of foveal hypoplasia

Holmström

Hellgren

et al. 2010

ABSTRACT.Purpose: To investigate whether optical coherence tomography (OCT) is helpful in the diagnosis of foveal hypoplasia in children. Methods: Children with albinism and aniridia were examined with Stratus OCT 3 software 4.0.1 (Carl Zeiss Meditec, Dublin, California, USA). A qualitative examination of the macular area was performed with a 128 A-scans ⁄ secondsingle-scan. Macular thickness was measured quantitatively with an automatic fast macular map protocol. The average thickness ⁄ volume of the macula was presented as numerical values and as a false colour code in nine modified early treatment of diabetic retinopathy study (ETDRS) areas (A1-A9). A previously collected control group of children was used for comparison. Results: Macular thickness in 13 children with albinism and three children with aniridia was measured with OCT. Comparison with healthy children in the same population was performed. Patients with albinism and aniridia had significantly thicker central macula (A1) and foveola than children in the control group. Conclusion: OCT was found to be useful in the diagnosis of foveal hypoplasia in children.

“…Few studies have been carried out on normal eyes in children. Mrugacz et al. (2004) examined 15 normal children aged 12–18 years, Altintas et al.…”

Section: Discussionmentioning

confidence: 99%

“…However, when evaluating retinal abnormalities assessed with OCT in children, it would be more appropriate to compare findings with normal values in children. Only a few studies have reported normal macular thickness in children (Mrugacz et al. 2004; Shields et al.…”

Section: Introductionmentioning

confidence: 99%

A population‐based study of macular thickness in full‐term children assessed with Stratus OCT: normative data and repeatability

Holmström

Alm

et al. 2009

. Purpose: We aimed to determine normal macular thickness values, assessed with optical coherence tomography (OCT), in a population of full‐term children of normal birthweight. Methods: A total of 56 children, aged 5–16 years, randomly chosen from the population register, were examined with Stratus OCT. Only children with visual acuity < 0.2 logMAR, spherical equivalent of − 3 to + 3 D and astigmatism < 2 D were included. The fast macular map protocol was used and three examinations were performed in each eye. One eye was then randomized for further analyses. Mean values for the nine ETDRS areas, foveal minimum thickness and macular volume were calculated for 55 eyes. Coefficients of variance and intraclass correlations were calculated for each area. Results: All children co‐operated well and no child was excluded for lack of concentration. Mean ± standard deviation central macular thickness was 204 ± 19 μm. Mean total macular volume was 7.11 ± 0.35 mm3. No correlations were found between age, gender and macular thickness. Coefficients of variance were < 2% and intraclass correlations were > 0.9 in all areas, except the foveal minimum. Conclusions: Normal values for macular thickness in healthy full‐term children were reported. As the Stratus OCT provides normal values only for adults, these data are a better alternative for comparison with children with retinal abnormalities. We concluded that OCT is suitable for examining the retina in children aged 5–16 years and has the same high level of repeatability as in adults.