Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review

Kislevitz, Mikaela; Akgul, Yucel; Wamsley, Christine E; Hoopman, John; Kenkel, Jeffrey M.

doi:10.1002/lsm.23219

Cited by 28 publications

(17 citation statements)

References 33 publications

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“…A lower OAC can be understood as a sparser distribution of collagen structures, consequently indicating a higher water content. In addition, collagen fibers could be dispersed among other waterabsorber high-molecular-weight molecules present in the extracellular matrix, such as hyaluronic acid [64]. When light is scattered through structures such as keratin and dense collagen, e.g., scar tissue, they appear bright on OCT images.…”

Section: Epidermis Structural Analysismentioning

confidence: 99%

Monoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studies

et al. 2022

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Organogels (ORGs) are remarkable matrices due to their versatile chemical composition and straightforward preparation. This study proposes the development of ORGs as dual drug-carrier systems, considering the application of synthetic monoketonic curcuminoid (m-CUR) and lidocaine (LDC) to treat topical inflammatory lesions. The monoketone curcuminoid (m-CUR) was synthesized by using an innovative method via a NbCl5–acid catalysis. ORGs were prepared by associating an aqueous phase composed of Pluronic F127 and LDC hydrochloride with an organic phase comprising isopropyl myristate (IPM), soy lecithin (LEC), and the synthesized m-CUR. Physicochemical characterization was performed to evaluate the influence of the organic phase on the ORGs supramolecular organization, permeation profiles, cytotoxicity, and epidermis structural characteristics. The physico-chemical properties of the ORGs were shown to be strongly dependent on the oil phase constitution. Results revealed that the incorporation of LEC and m-CUR shifted the sol-gel transition temperature, and that the addition of LDC enhanced the rheological G′/G″ ratio to higher values compared to original ORGs. Consequently, highly structured gels lead to gradual and controlled LDC permeation profiles from the ORG formulations. Porcine ear skin epidermis was treated with ORGs and evaluated by infrared spectroscopy (FTIR), where the stratum corneum lipids were shown to transition from a hexagonal to a liquid crystal phase. Quantitative optical coherence tomography (OCT) analysis revealed that LEC and m-CUR additives modify skin structuring. Data from this study pointed ORGs as promising formulations for skin-delivery.

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Section: Epidermis Structural Analysismentioning

confidence: 99%

Monoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studies

et al. 2022

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“…In dermatology, it is used primarily to assess and diagnose neoplastic diseases (both melanocytic and nonmelanocytic), inflammatory changes and those related to the keratosis disorders. [8][9][10][11][12][13][14][15][16] This method also is used to assess the extent of planned tumour removal surgery as well as to monitor the treatment. 13 Information on the use of OCT in animals is rare, and most of the work on skin evaluation has been performed on humans, while only a few studies have looked at laboratory animals.…”

Section: Introductionmentioning

confidence: 99%

“…In medicine, OCT is used widely in ophthalmology. In dermatology, it is used primarily to assess and diagnose neoplastic diseases (both melanocytic and non‐melanocytic), inflammatory changes and those related to the keratosis disorders 8–16 . This method also is used to assess the extent of planned tumour removal surgery as well as to monitor the treatment 13 .…”

Section: Introductionmentioning

confidence: 99%

The use of optical coherence tomography for skin evaluation in healthy rats

Szczepanik

Balicki

Śmiech

et al. 2022

Veterinary Dermatology

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Background: Noninvasive diagnostic techniques allow for morphological and morphometric in vivo evaluation of the skin. Optical coherence tomography (OCT) is a method that allows visualization of dermal structures up to several 100 μm with a resolution of 3-7.5 μm. Objectives:The aim of the study was the morphological and morphometric assessment of rats' skin using SD-OCT.Animals: Fifteen male Wistar rats, aged 3 and 8 months, weighing 350-450 g. Materials and Methods:The skin of the plantar metatarsal area of the right pelvic limb was assessed. The measurements were performed using Spectral Domain Optical Coherence Tomography (SD-OCT) scans and histological images.Results: Spectral Domain Optical Coherence Tomography could determine the boundary between the epidermis and the dermis. Apart from the stratum corneum (SC), it did not allow for the differentiation of the individual epidermal layers. In the SD-OCT and in the histological examination, the mean thicknesses of the layers (μm ± SD) were (respectively):

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“…High‐resolution photography equipped with various filters and polarized lights is commonly used to evaluate fine lines, wrinkles, scars, skin tone, pigmentation, clogged pores and presence of bacteria [9]. Beyond the skin surface, advanced sound and light‐based scanners, including ultrasound and optical coherence tomography (OCT), can evaluate epidermal and dermal ultrastructure, allowing for quantitative measurement of epidermal and dermal thickness, skin texture, dermal density (attenuation coefficient), vasculature and blood flow [9–12]. Skin function has been assessed by measuring skin secretions (moisture, pH, and sebum content), skin permeability (transepidermal water loss [TEWL]) and viscoelastic properties (elastic deformation laxity and stiffness) [9,13–16].…”

Section: Introductionmentioning

confidence: 99%

Novel Use of Non‐Invasive Devices and Microbiopsies to Assess Facial Skin Rejuvenation Following Laser Treatment

Kislevitz

Lu²,

Wamsley

et al. 2020

Lasers Surg Med

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Background and Objective: Patient-reported outcomes and blinded observer rating scales are subjective and unreliable but are extensively utilized to evaluate cosmetic office-based treatments, including ablative lasers. This study aims to assess the practicality of using noninvasive and minimally invasive methods for objective skin assessment following a skin rejuvenation treatment. Study Design/Materials and Methods: Twelve patients received a single 1,470/2,940 nm laser treatment for facial rejuvenation. Assessments were performed before treatment, and 7 days, 3 weeks, and 3 months posttreatment. Images were taken with the VISIA Skin Analysis System to measure wrinkles, textures, pores, ultraviolet (UV) spots, brown spots, red areas, and porphyrins. Other non-invasive skin measurements-highresolution ultrasonography, optical coherence tomography, transepidermal water loss and BTC 2000-were used to measure epidermal/dermal thickness, blood flow, surface roughness, wrinkle depth, attenuation coefficient, elasticity, laxity, and viscoelasticity. Microbiopsies (0.33 mm in diameter or the equivalent of a 23-gauge needle) were collected for histology and gene expression of tissue rejuvenation. Results: Significant improvement in facial skin aesthetics after laser treatment was recorded in UV spots, brown spots and pores after 3 weeks and in UV spots and brown spots after 3 months. The dermal attenuation coefficient decreased significantly at 3 weeks, while blood flow 0.5 to 0.7 mm below the skin surface increased significantly between 5 days and 3 weeks following treatment. Epidermal hyaluronic acid expression assessed by immunostaining and expression of inflammatory genes were elevated at 7 days posttreatment compared with untreated or 3 months posttreatment. There were no statistically significant changes in collagen or elastin-related genes between groups at the studied parameters. Conclusion: Non-invasive devices can be effectively used to provide objective measurements of skin structure, pigmentation, blood flow, and elasticity to assess the efficacy of facial skin rejuvenation treatments. Furthermore, microbiopsies can objectively evaluate facial skin rejuvenation without scarring. Using non-invasive skin imaging, a single treatment with the 1,470/2,940 nm laser was observed to be effective in improving skin appearance after 3 months, namely in reducing UV spots and brown spots, without significant changes in the tissue at the molecular level, as assessed by microbiopsy. Lasers Surg.

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Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review

Cited by 28 publications

References 33 publications

Monoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studies

Monoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studies

The use of optical coherence tomography for skin evaluation in healthy rats

Novel Use of Non‐Invasive Devices and Microbiopsies to Assess Facial Skin Rejuvenation Following Laser Treatment

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