Use of nonlinear upconverting nanoparticles provides increased spatial resolution in fluorescence diffuse imaging

Svenmarker, Pontus; Xu, Cuilian; Andersson‐Engels, Stefan

doi:10.1364/ol.35.002789

Cited by 22 publications

(15 citation statements)

References 15 publications

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“…In fact, it is a useful indication of the upper limit for the excitation radiation power as higher ones are not useful for increasing the upconversion signal. It is also worth underlining that upconverting NPs can increase the spatial resolution in fluorescence diffuse imaging, as recently reported by Svenmarker et al 24 and Maestro et al 25 Moreover, the UC emissions are easily measurable for excitation power densities as low as 20 W cm À2 (see Fig. 4).…”

Section: à2supporting

confidence: 58%

Lanthanide doped upconverting colloidal CaF2 nanoparticles prepared by a single-step hydrothermal method: toward efficient materials with near infrared-to-near infrared upconversion emission

et al. 2011

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Section: à2supporting

confidence: 58%

Lanthanide doped upconverting colloidal CaF2 nanoparticles prepared by a single-step hydrothermal method: toward efficient materials with near infrared-to-near infrared upconversion emission

et al. 2011

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“…Firstly, the QY is much higher for UCNPs at low photon density rates, which constitutes one main reason for the interest in them and removes the reliance of and restriction to focal volume excitation, thus broadening their field of application. 19,20 Secondly, the excitation for UC emission relies on intermediate energy levels, 21 complicating the process. This has led to some less successful attempts to utilize pulsed excitation for UCNPs in the past.…”

Section: Introductionmentioning

confidence: 99%

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Liu

Dumlupinar

et al. 2013

Nanoscale

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-Engels, S. (2013). Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power. Nanoscale, 5(20), 10034-10040. https://doi.org/10.1039/c3nr01917aRegistered Charity Number 207890 Accepted ManuscriptThis is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, which is prior to technical editing, formatting and proof reading. This free service from RSC Publishing allows authors to make their results available to the community, in citable form, before publication of the edited article. This Accepted Manuscript will be replaced by the edited and formatted Advance Article as soon as this is available.To cite this manuscript please use its permanent Digital Object Identifier (DOI®), which is identical for all formats of publication.More information about Accepted Manuscripts can be found in the Information for Authors.Please note that technical editing may introduce minor changes to the text and/or graphics contained in the manuscript submitted by the author(s) which may alter content, and that the standard Terms & Conditions and the ethical guidelines that apply to the journal are still applicable. In no event shall the RSC be held responsible for any errors or omissions in these Accepted Manuscript manuscripts or any consequences arising from the use of any information contained in them. We have accomplished deep tissue optical imaging of upconverting nanoparticles at 800 nm, using millisecond single pulse excitation with high peak power. This is achieved by carefully choosing the pulse parameters, derived from time-resolved rateequation analysis, which result in higher intrinsic quantum yield that is utilized by upconverting nanoparticles for generating this near infrared upconversion emission. The pulsed excitation approach thus promises previously unreachable imaging depths and shorter data acquisition times compared with continuous wave excitation, while simultaneously keeping the possible thermal side-effects of the excitation light moderate. These key results facilitate means to break through the general shallow depth limit of upconverting-nanoparticle-based fluorescence techniques, necessary for a range of biomedical applications, including diffuse optical imaging, photodynamic therapy and remote activation of biomolecules in deep tissues. www.rsc.org/nanoscale

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“…Since the emission utilized in diffuse imaging corresponds typically to two/three‐photon processes, this can be used to confine the excitation volume, leading to an increase in the spatial resolution. The enhancement of the spatial resolution has been demonstrated for diffuse planar imaging as well as for luminescence diffuse optical tomography …”

Section: Excitation Manipulation Of Upconversion Nanoparticlesmentioning

confidence: 99%

“…Since the emission utilized in diffuse imaging corresponds typically to two/three-photon processes, this can be used to confine the excitation volume, leading to an increase in the spatial resolution. The enhancement of the spatial resolution has been demonstrated for diffuse planar imaging [176,177] as well as for luminescence diffuse optical tomography. [5,6] Interestingly, the nonlinear power dependence of the UCNPs can be exploited to increase the information density for luminescence diffuse optical tomography from a given volume by carefully designing the excitation scheme to include multi-beam excitation.…”

Section: Nonlinear Power-density Response For Multibeam Luminescence mentioning

confidence: 99%

Photon Upconversion Kinetic Nanosystems and Their Optical Response

Liu

Huang

Valiev

et al. 2017

Laser & Photonics Reviews

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Lanthanide-doped photon upconversion nanoparticles (UCNPs) are capable of converting low-intensity near-infrared light to UV and visible emission through the synergistic effects of light excitation and mutual interactions between doped ions. UCNPs have attracted strong interest as unique spectrum converters and found a multitude of applications in areas like biomedical imaging, energy harvesting and information technology. UCNPs are distinct from many other types of luminescent materials in terms of the involvement of a host lattice and multiple optical centers, i.e., trivalent lanthanide ions with manyfolds of accessible long-lived energy states, in individual nanoparticles. The mutual interactions between these optical centers, i.e., sequential energy transfers, make them operate as an integrated unit and co-determine the luminescence kinetics and other optical properties of the individual nanoparticle. Thus, each nanoparticle consititutes a kinetic optical system. In this work, we explore UCNPs from the outset of being such kinetic optical systems and review their physical formation, the underlying photophysics, macroscopic statistical description, and their response to various optical stimuli in the spectral, polarization, intensity, temporal and frequency domains, and demonstrate ways that their optical output can be optimized by manipulating the excitation schemes. Our review highlights upconversion nanotechnology as an interdisciplinary field across chemistry, physics and biomedical engineering, with great future possibilities, flexibility and ramifications. We outline some of the potential directions of upconversion nanoparticle research.

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Use of nonlinear upconverting nanoparticles provides increased spatial resolution in fluorescence diffuse imaging

Cited by 22 publications

References 15 publications

Lanthanide doped upconverting colloidal CaF2 nanoparticles prepared by a single-step hydrothermal method: toward efficient materials with near infrared-to-near infrared upconversion emission

Lanthanide doped upconverting colloidal CaF2 nanoparticles prepared by a single-step hydrothermal method: toward efficient materials with near infrared-to-near infrared upconversion emission

Deep tissue optical imaging of upconverting nanoparticles enabled by exploiting higher intrinsic quantum yield through use of millisecond single pulse excitation with high peak power

Photon Upconversion Kinetic Nanosystems and Their Optical Response

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