Use of Noninvasive Interactive Neurostimulation to Improve Short-Term Recovery in Patients with Surgically Repaired Bimalleolar Ankle Fractures: A Prospective, Randomized Clinical Trial

Effect of Interactive Neurostimulation Therapy on Inflammatory Response in Patients With Chronic and Recurrent Mechanical Neck Pain

“…Using frozen lymphocytes from 4 healthy subjects, Pyne-Geithman and Clark 17,18 reported, in conference proceedings, that the intracellular levels of proinflammatory cytokines were altered within 10 minutes post-InterX application. Other work has demonstrated beneficial effects of InterX application in acute postoperative cases, in terms of reduced edema in ankle fracture, 6 and attenuation of pain during recovery from bone fracture 4 and after knee replacement surgery. 5 These postsurgical studies suggest that the application of interactive neurostimulation may have a dampening effect on inflammation thereby providing some credence to the claim that InterX application may be beneficial in pain control and reducing acute inflammation.…”

“…3,4 To date, 3 randomized controlled clinical trials using different models of InterX have shown advantage of this modality over placebo application in postoperative recovery from bone fractures, 4 knee replacement surgery, 5 and ankle fracture. 6 Interestingly, in a recent study, Schabrun et al 7 have shown that interactive neurostimulation therapy (NIN) may be also efficacious for managing musculoskeletal conditions, such as myofascial pain syndrome, and be of clinical significance in some patients with shoulder or NP.…”

“…However, the existing clinical reports suggest that NIN may exert an anti-inflammatory effect in the area of local inflammation. 5,6 The present study was undertaken to investigate if the InterX T 5000 therapy, independent of other therapeutic interventions, might attenuate/normalize the production of inflammatory mediators in NP patients. Objective measures of pain and function were done immediately pre-InterX5000 and post-InterX5000 therapy.…”

A Comparison of the Hypoalgesic Effects of Transcutaneous Electrical Nerve Stimulation (TENS) and Non-invasive Interactive Neurostimulation (InterX®) on Experimentally Induced Blunt Pressure Pain Using Healthy Human Volunteers

“…Manufacturers claim that non‐invasive interactive neurostimulation relieves pain and promotes healing of various injuries (6). All three randomized controlled clinical trials published to date have demonstrated superiority for non‐invasive interactive neurostimulation over placebo (i.e., a no current sham device) for knee osteoarthritis (7), postoperative recovery from bone fractures (8) and operative reduction and internal fixation of bimalleolar, AO type B2 ankle fractures (9).…”

Non-invasive interactive neurostimulation (InterX ™) reduces acute pain in patients following total knee replacement surgery: a randomised, controlled trial

“…The handheld application of NIN has previously been shown to significantly reduce pain, medication intake and inflammation while also increasing range of motion following hip and ankle surgery[25,26]. In this study, the Flexible Array Electrode was used on post-operative TKR patients to treat their post-operative pain in combination with pharmaceutical analgesia and an aggressive rehabilitation protocol.…”