Use of non-steroidal anti-inflammatory drugs in paediatrics

Close, Rosie; Bale, Peter; Armon, Kate

doi:10.1136/archdischild-2019-317228

Cited by 2 publications

(3 citation statements)

References 15 publications

(22 reference statements)

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“…Paracetamol is particularly appreciated in dentistry being the most frequently prescribed analgesic in dental settings. 13 , 14 Scientific discoveries leading to paracetamol have started in 1886, however, it was not until 1955 when it was officially introduced into the pharmacological market initially as a prescribed, and a year later as over-the-counter analgesic and antipyretic. 15 Compared to NSAIDs, the mechanism of action of paracetamol is less clear, but is believed to involve a central analgesic effect that is mediated through activation of descending serotonergic pathways.…”

Section: Discussionmentioning

confidence: 99%

What the dental practitioner needs to know about pharmaco-therapeutic modalities of COVID-19 treatment: A review

Dar‐Odeh¹,

Elsayed²,

Babkair³

et al. 2021

Journal of Dental Sciences

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Section: Discussionmentioning

confidence: 99%

What the dental practitioner needs to know about pharmaco-therapeutic modalities of COVID-19 treatment: A review

Dar‐Odeh¹,

Elsayed²,

Babkair³

et al. 2021

Journal of Dental Sciences

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“…The selective inhibition of COX-2 is associated with less gastrointestinal intolerance. Prostaglandins are stunning vasodilators and proinflammatory factors that stimulate the production of nociceptors [20]. Moreover, unlike acetaminophen, NSAIDs are also considered to have a peripheral anti-inflammatory role [3].…”

Section: Nsaidsmentioning

confidence: 99%

“…NSAIDs have been associated with several adverse events including gastritis, gastrointestinal bleeding and kidney failure; however, these are uncommon in the pediatric age. Due to its association with Reye's syndrome, the use of aspirin in children has decreased in recent years and is limited to specific rheumatologic disorders [3,20].…”

Section: Nsaidsmentioning

confidence: 99%

Pain Evaluation and Treatment in Children: A Practical Approach

et al. 2023

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Pain is the most common complaint reported by children who access the emergency departments, but despite its frequency and the availability of many international guidelines, it often remains underreported and undertreated. Recently, the American Academy of Pediatrics and the American Pain Society have reiterated the importance of a multidisciplinary approach in order to eliminate pain in children. In all pediatric settings, an adequate assessment is the initial stage in a proper clinical approach to pain, especially in the emergency departments; therefore, an increasing number of age-related tools have been validated. A wide range of analgesic agents are currently available for pain management, and they should be tailored according to the patient’s age, the drug’s pharmacokinetics and the intensity of pain. In order to facilitate the choice of the appropriate drug, a treatment algorithm based on a ladder approach can be used. Moreover, non-pharmacological techniques should be considered to alleviate anxiety and distress in pediatric age. This review aims to offer a simple but intuitive description of the best strategies for pain relief in children, starting with the prompt recognition and quantification of pain through adequate assessment scales, and following with the identification of the most appropriate therapeutic choice among the ones available for pediatric age.

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Use of non-steroidal anti-inflammatory drugs in paediatrics

Cited by 2 publications

References 15 publications

What the dental practitioner needs to know about pharmaco-therapeutic modalities of COVID-19 treatment: A review

What the dental practitioner needs to know about pharmaco-therapeutic modalities of COVID-19 treatment: A review

Pain Evaluation and Treatment in Children: A Practical Approach

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