Use of NMR imaging in the optimization of a compression-coated regulated release system

Fahie, Brian J; Nangia, Avinash; Chopra, Sham K; Fyfe, C. A.; Grondey, H.; Blazek, Almira

doi:10.1016/s0168-3659(97)00166-1

Cited by 32 publications

(12 citation statements)

References 6 publications

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“…[18][19][20] Examples of using MRI in quantitative and non-invasive studies of solid dosage forms include investigating events during the dissolution process, [21][22][23][24][25] identifying relationships between dissolution and formulation parameters [26][27][28][29] and mapping of tablet porosimetry. [30][31][32][33] MRI has also been used to correlate drug release profiles with dissolution events for the tablet being examined ex situ 34 and in situ in the dissolution equipment. 35,36 In addition, magnetic markers have been used to monitor the location and transit velocities of tablets when in vivo and correlated to dissolution measured by plasma concentrations.…”

Section: Introductionmentioning

confidence: 99%

MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell

Shiko

Gladden

Sederman

et al. 2011

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell

Shiko

Gladden

Sederman

et al. 2011

Journal of Pharmaceutical Sciences

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“…In addition, nuclear magnetic resonance (NMR) imaging has been used to follow drug release from a solid phase, providing valuable information about the dissolution rate 6 .…”

Section: Introductionmentioning

confidence: 99%

NMR of Microencapsulated Fish Oil Samples During In Vitro Digestion

et al. 2008

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The use of nuclear magnetic resonance (NMR) spectroscopy for characterising microencapsulated tuna oil powders (25% and 50% w/w oil) and assessing the behaviour of the microcapsules on their exposure to water, simulated gastric fluid or to sequential exposure of simulated gastric and intestinal fluids was examined. The matrices used for encapsulation were physical mixtures of casein or whey protein in combination with carbohydrates (dextrose monohydrate with either dried glucose syrup or a physically modified resistant starch) or heated mixtures of these matrices. Solid-state 13 C cross-polarised magic angle spinning NMR and dipolar de-coupled magic angle spinning NMR record the 13 C NMR signals of the encapsulant material and that of the encapsulated oil, respectively. 1 H and 13 C solution NMR were used to investigate the relative increase in mobility of the various encapsulant matrices due to their dissolution on exposure to gastrointestinal fluids. The results suggested that the dissolution characteristics of matrices of microencapsulated oil powders were dependent on the type of milk protein and carbohydrate used and whether the protein-carbohydrate matrices were heat-treated prior to encapsulation of the oil.

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“…Drug release from tablets has been studied by various experimental methods. Some of these also provide spatial information; such methods are a combination of FTIR imaging and a dissolution test [33], and conventional 1 H MR imaging methods [34,35]. A combination of FTIR imaging in the ATR mode and a conventional dissolution test provides quantitative information of changes in the solid tablet as well as in the liquid phase.…”

Section: Resultsmentioning

confidence: 99%

“…But the sensitivity of this method is limited when spectral bands overlap or when a material has weak infrared absorption. Conventional 1 H MRI can help in determining drug release from a tablet based on the signal loss at the position of the undissolved part of the tablet [34], as well as from changes of relaxation times in the solution due to the released part of the tablet. The relaxation properties can be significantly changed if a gel is formed around the tablet.…”

Section: Resultsmentioning

confidence: 99%