Use of nesiritide in Ebstein's anomaly

Tavakol, Morteza; Banko, Lessan; Schifter, David

doi:10.1055/s-0031-1278281

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…There has also been recent use of nesiritide, a recombinant human brain natriuretic peptide, which has resulted in improved hemodynamic actions, enhanced sodium excretion, and suppression of the renin-angiotensin-aldosterone pathway and sympathetic nervous system. 19,27 Antibiotic prophylaxis is not usually necessary in those patients who are acyanotic and unoperated. However, it is recommended before dental procedures if there is cyanosis and/or if the patient has a prosthetic heart valve.…”

Section: Medical Treatmentmentioning

confidence: 99%

Ebstein Anomaly: A Review

Galea¹,

Ellul²,

Schembri³

et al. 2014

Neonatal Network

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Cardiac congenital abnormalities are a leading cause in neonatal mortality occurring in up to 1 in 200 of live births. Ebstein anomaly, also known as Kassamali anomaly, accounts for 1 percent of all congenital cardiac anomalies. This congenital abnormality involves malformation of the tricuspid valve and of the right ventricle. In this review, the causes of the anomaly are outlined and the pathophysiology is discussed, with a focus on the symptoms, management, and treatments available to date.

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Section: Medical Treatmentmentioning

confidence: 99%

Ebstein Anomaly: A Review

Galea¹,

Ellul²,

Schembri³

et al. 2014

Neonatal Network

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“…14 In 2008, the case was reported about a 77-year-old man with congestive heart failure due to a previously diagnosed condition of Ebstein's anomaly. 4 Recently in 2012, one report was published which described the unusual first presentation of Ebstein's anomaly in a 72-year-old patient. 11 The patient of our case report was atypical, as she presented to the hospital for the first time at the age of 80 years and had not received any treatment prior to the referral to our hospital.…”

Section: Discussionmentioning

confidence: 99%

“…3 Ebstein's anomaly is characterized by tricuspid valve abnormality with apical displacement of the septal and posterior leaflets from the atrioventricular annulus into the right ventricle, leading to the 'atrialization' of a portion of the right ventricle. 4 The clinical presentation depends upon the severity of deformity, whether it is mild, moderate or severe; the age of onset of symptoms can also vary from the patient to patient. 4 Only 5% of patients with Ebstein's anomaly survive beyond the fifth decade and the initial presentation by older patients is rare.…”

Section: Introductionmentioning

confidence: 99%

“…4 The clinical presentation depends upon the severity of deformity, whether it is mild, moderate or severe; the age of onset of symptoms can also vary from the patient to patient. 4 Only 5% of patients with Ebstein's anomaly survive beyond the fifth decade and the initial presentation by older patients is rare. 5 There are case reports of Ebstein's anomaly in offsprings following consumption of lithium during early pregnancy by mother.…”

Section: Introductionmentioning

confidence: 99%

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First presentation of Ebstein’s anomaly in an 80-year-old female patient and unusual occurrence of psychiatric illness in her male offsprings

2013

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An 80-year-old female Ebstein’s anomaly patient presented with palpitation and dyspnea of New York Heart Association class III. This is probably the eldest surviving Ebstein’s anomaly patient presenting for the first time with cardiac symptoms at the age of 80 years. She had four sons and two daughters, among whom the first three sons developed psychiatric disorders after 38 years of age, with one son committing suicide because of major depressive episode. This case is unique because of the late age of initial presentation with cardiac problem and the occurrence of psychiatric illness in the male offsprings of the patient. Journal of Advances in Internal Medicine 2013;02(01):21-23 DOI: http://dx.doi.org/10.3126/jaim.v2i1.7634

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“…According to guidelines for physical activity, there are no limitations on participating in sports for people with a modest Ebstein abnormality having a heart size that is close to normal with no arrhythmia. Patients are recommended not to exercise in cases of severe, untreated Ebstein's anomalies [ 29 ].…”

Section: Reviewmentioning

confidence: 99%

Neurological, Extracardiac, and Cardiac Manifestations of Ebstein’s Anomaly Along With its Genetics, Diagnostic Techniques, Treatment Updates, and the Future Ahead

Farhan¹,

Prajjwal²,

Sai³

et al. 2023

Cureus

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Ebstein's anomaly is a congenital heart defect characterized by the displacement of the tricuspid valve, and its leaflets to be malformed. Due to the defect involving the tricuspid valve, there is a reverse flow of blood into the right-sided atrium, which may lead to cardiac hypertrophy and edema of the lower extremities. There is a decreased flow of blood out of the right heart due to reduced right ventricular contractility and tricuspid regurgitation. Children afflicted with this anomaly usually suffer from atrial septal defect and this is usually diagnosed before birth on a routine ultrasound scan. In neonates, cyanosis can be seen due to right-to-left atrial shunting or as a result of severe congestive heart failure. If the infant has pulmonary hypertension, cyanosis is markedly increased as there will be a limitation in pulmonary blood flow. In adults, arrhythmias, cyanosis, and heart failure are seen. The bundle of Kent leads to the formation of an electrical conduction abnormality between the right ventricle and atrium. This leads to a condition commonly known as Wolff-Parkinson-White syndrome in patients. An enlarged spherical heart is usually present on a chest Xray. ECG changes of Ebstein's anomaly show taller than usual P waves, PR prolongation, and right bundle branch block. There can be certain neurological and extracardiac manifestations too such as hemiplegia, stroke, dysarthria, etc. During fetal life, specifically at 16 and 20 weeks of gestation, the anomaly can be diagnosed via echocardiography. Prostaglandin infusion (PGE1) is given to maintain pulmonary circulation in neonates if cyanosis is seen. In children and adults with congestive cardiac failure due to this anomaly, medical management includes digoxin, beta-blockers, diuretics, and angiotensin converting enzyme (ACE) inhibitors to improve heart failure. Surgical treatment includes valve reconstruction. In this article, we review the pathophysiology, genetics, diagnosis, management, and prognosis of Ebstein's Anomaly along with a comprehensive discussion on its genetics, neurological manifestations, extracardiac features, and current advancements in treatment.

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Use of nesiritide in Ebstein's anomaly

Cited by 3 publications

References 4 publications

Ebstein Anomaly: A Review

Ebstein Anomaly: A Review

First presentation of Ebstein’s anomaly in an 80-year-old female patient and unusual occurrence of psychiatric illness in her male offsprings

Neurological, Extracardiac, and Cardiac Manifestations of Ebstein’s Anomaly Along With its Genetics, Diagnostic Techniques, Treatment Updates, and the Future Ahead

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