Use of Nebulized Antibiotics for Acute Infections in Chronic Sinusitis

Vaughan, Winston C.; Carvalho, Gerard J.

doi:10.1067/mhn.2002.129738

Cited by 118 publications

(97 citation statements)

References 24 publications

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“…Up to 88% of patients experience significant improvement, good quality of life, and few local side effects (rhinitis), after four weeks of treatment (Vaughan and Carvalho, 2002). This symptomatic relief is concurrent with reversal of the endoscopic findings.…”

Section: Antimicrobialsmentioning

confidence: 83%

“…Nebulized medications are a novel topical approach to rhinosinusitis, and have been used for the past decade in clinical practice in Europe. In Japan, they were adopted in 1950, and in the United States, nebulizers and nebulized medications are covered by most medical insurances (Vaughan and Carvalho, 2002). Nebulization devices provide an aerosolized mist which is created by a mechanical pulse.…”

Section: Major Delivery Techniquesmentioning

confidence: 99%

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Topical Membrane Therapy for Chronic Rhinosinusitis

Shikani¹

2011

Peculiar Aspects of Rhinosinusitis

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Section: Antimicrobialsmentioning

confidence: 83%

Section: Major Delivery Techniquesmentioning

confidence: 99%

Topical Membrane Therapy for Chronic Rhinosinusitis

Shikani¹

2011

Peculiar Aspects of Rhinosinusitis

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“…Their routine use cannot be recommended. Some case series have reported effectiveness, particularly in recalcitrant cases of CRS, [783][784][785][786] suggesting there may be a role in unusual cases. VII.E.5.…”

Section: S93mentioning

confidence: 99%

“…1462,1463 Topical antibiotic use has shown reduced postoperative CF sinus exacerbations, endoscopic score improvement, and reduced symptoms. 782,785,1464 Dornase alfa reduces mucus viscosity and improves objective CRS outcome measures. 1465,1466 Oral macrolides possess antibacterial and anti-inflammatory effects with support for use in CF pulmonary manifestations and may be utilized to treat CF-related CRS.…”

Section: Xiic Rs Special Considerations: Cfmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…In a systematic review on the use of topical antimicrobials delivered in sinonasal irrigation by Lim et al, 84 the authors noted that there was no sufficient evidence to justify their use in CRS patients in general, but a high level of evidence was reported regarding use in the CF CRS population (IIb). 85 Topical antibiotics have fewer adverse effects than oral antibiotics and may achieve a higher drug concentration at the target site. 26 Topical tobramycin has been shown to be effective in reducing symptoms and reveals improvements in endoscopic scores in sinusitis.…”

Section: Medical Managementmentioning

confidence: 99%