Use of near-infrared spectroscopy in the investigation of brain activation during cognitive aging: A systematic review of an emerging area of research

Agbangla, Nounagnon Frutueux; Audiffren, Michel; Albinet, Cédric T.

doi:10.1016/j.arr.2017.07.003

Cited by 62 publications

(56 citation statements)

References 97 publications

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“…Both no-HTN and controlled-HTN achieved similar PFC oxygenation (measured by TSI) during the Stroop tasks, achieved through increases in O 2 Hb and reductions in HHB. These differential changes in O 2 Hb and HHb during cognitive activation have been previously suggested to reflect cortical activation (2,44). Changes in O 2 Hb were attenuated when covarying for mean change in forehead skin temperature (proxy of skin blood flow), suggesting increases in O 2 Hb during the Stroop task may partially stem from changes in skin blood flow.…”

Section: Microvascular Reactivity Neurovascular Coupling and Cognitmentioning

confidence: 56%

Neurovascular coupling during cognitive activity in adults with controlled hypertension

Lefferts

DeBlois

Barreira

et al. 2018

Journal of Applied Physiology

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Hypertension, even when controlled, may accelerate arterial stiffening and impair the ability of the cerebrovasculature to increase blood flow to support neural activity (neurovascular coupling [NVC]). Optimal NVC depends on continuous, non-pulsatile flow, which is partially determined by extra- and intra-cranial vessel function. We sought to compare extra- and intra-cranial hemodynamics during cognitive activity (Stroop task) in 30 middle-aged, well-controlled medicated hypertensive and 30 age-, sex-, and body mass index (BMI)-matched non-hypertensive adults (56±6 yrs, BMI 28.2±2.9 kg/m; 32 men). Aortic and carotid (single-point) pulse wave velocity (PWV) were assessed via tonometry and ultrasound respectively. Carotid and middle cerebral artery (MCA) blood velocity pulsatility were measured via ultrasound and Doppler. Prefrontal cortex (PFC) oxygenation (tissue saturation index; TSI) was measured using near-infrared spectroscopy. Accuracy and reaction times were computed to assess cognitive performance. Stroop performance was similar between groups (p>0.01). Aortic and carotid PWV increased, carotid flow pulsatility decreased (p<0.01), and MCA flow pulsatility and PFC TSI were maintained during Stroop (p>0.01). Our findings indicate that middle-age adults with medically-controlled hypertension and adults without hypertension demonstrate similar intra- and extra-cranial cerebrovascular reactivity during cognitive engagement. Despite increases in large artery stiffness, middle-aged adults with controlled-hypertension and without hypertension exhibit reductions in extracranial flow pulsatility during cognitive engagement that may be part of a concerted cerebrovascular response to support downstream cerebral oxygenation and overall NVC.

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Section: Microvascular Reactivity Neurovascular Coupling and Cognitmentioning

confidence: 56%

Neurovascular coupling during cognitive activity in adults with controlled hypertension

Lefferts

DeBlois

Barreira

et al. 2018

Journal of Applied Physiology

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“…Emerging alternatives to fMRI, based on near-infrared diffuse optical techniques, allow measurements in more realistic environments and during motion (Boas et al, 2014;Scholkmann et al, 2014). Accumulating evidence supports the use of these techniques for the study of frontal hemodynamic and metabolic changes (Agbangla et al, 2017;Gramigna et al, 2017). These diffuse optical techniques such as fNIRS (Durduran et al, 2010;Ferrari and Quaresima, 2012) allow the study of tissue composition by emitting near-infrared light (∼650-950 nm) into biological tissue and collecting the photons that undergo multiple scattering and absorption (i.e., diffuse) and emerge few centimeters away from the injection point (Delpy and Cope, 1997;Durduran et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Udina

Avtzi

Durdurán

et al. 2020

Front. Aging Neurosci.

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The integrity of the frontal areas of the brain, specifically the prefrontal cortex, are critical to preserve cognition and mobility in late life. Prefrontal cortex regions are involved in executive functions and gait control and have been related to the performance of dual-tasks. Dual-task performance assessment may help identify older adults at risk of negative health outcomes. As an alternative to neuroimaging techniques that do not allow assessment during actual motion, functional Near-Infrared Spectroscopy (fNIRS) is a non-invasive technique that can assess neural activation through the measurement of cortical oxygenated and deoxygenated hemoglobin levels, while the person is performing a motor task in a natural environment as well as during cognitive tasks. The aim of this review was to describe the use of fNIRS to study frontal lobe hemodynamics during cognitive, motor and dual-tasks in older adults. From the 46 included publications, 20 studies used only cognitive tasks, three studies used motor tasks and 23 used dual-tasks. Our findings suggest that fNIRS detects changes in frontal activation in older adults (cognitively healthy and mild cognitive impairment), especially while performing cognitive and dual-tasks. In both the comparison between older and younger adults, and in people with different neurological conditions, compared to healthier controls, the prefrontal cortex seems to experience a higher activation, which could be interpreted in the context of proposed neural inefficiency and limited capacity models. Further research is needed to establish standardized fNIRS protocols, study the cerebral hemodynamic in different neurological and systemic conditions that might influence cortical activation and explore its role in predicting incident health outcomes such as dementia.

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“…Additionally, functional MRI requires that the patient's head be fixed as much as possible during scanning, which makes MRI examination of ET patients more difficult, and the examination results are less reliable. NIRS, which reflects the neuronal activities in the cerebral cortex based on neurovascular coupling, has the advantage of being noninvasive, immediate, continuous, portable, and interference-free during measurement as compared with functional MRI [10], which enables analysis of patients' functional recovery during their daily activities. In our study, patients showed tremors during the finger-to-nose task (both hands) and writing task before surgery which almost completely disappeared after tcMRgFUS thalamotomy.…”

Section: Discussionmentioning

confidence: 99%

Clinical effect of unilateral transcranial magnetic resonance-guided focused ultrasound thalamotomy in patients with essential tremor as evaluated by functional near-infrared spectroscopy

Kong

Zong

Zhang

et al. 2020

Preprint

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Background: Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) surgery is a noninvasive thermal ablation therapy for neurological conditions such as essential tremor (ET). However, most studies on the therapeutic mechanisms of this technique are limited to the visualization of brain structure and network activities with resting state functional magnetic resonance imaging. We aimed to investigate the effect of tcMRgFUS on the cortical level of the motor network using functional near-infrared spectroscopy (fNIRS).Results: Two sample paired t-tests revealed that only channel 6 (left primary motor and somatosensory cortices), and channel 45 (right dorsolateral prefrontal cortex) were significantly activated in the writing task after MRgFUS treatment compared to the task before MRgFUS treatment (CH6: t(6) = 3.42, p < 0.05, Cohen's d = 1.29; CH45: t(6) = 2.47, p < 0.05, Cohen's d = 0.93).Conclusions: We identified changes in relevant cortical activity after surgery and found that fNIRS can provide an important supplement to objective assessment of the clinical efficacy of tcMRgFUS.

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Use of near-infrared spectroscopy in the investigation of brain activation during cognitive aging: A systematic review of an emerging area of research

Cited by 62 publications

References 97 publications

Neurovascular coupling during cognitive activity in adults with controlled hypertension

Neurovascular coupling during cognitive activity in adults with controlled hypertension

Functional Near-Infrared Spectroscopy to Study Cerebral Hemodynamics in Older Adults During Cognitive and Motor Tasks: A Review

Clinical effect of unilateral transcranial magnetic resonance-guided focused ultrasound thalamotomy in patients with essential tremor as evaluated by functional near-infrared spectroscopy

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