Use of natural killer cells in hematopoetic stem cell transplantation

Immune recovery in children undergoing allogeneic stem cell transplantation: absolute CD8+CD3+ count reconstitution is associated with survival

“…17 We and others could show that NK cells can be used as adoptive immunotherapy after haploidentical SCT. 32,33 In addition, high levels of NK cells may be protective against the development of GvHD. 34 Immune reconstitution studies, to date, have not measured lymphocyte subsets in short intervals.…”

Disease stage stratified effects of cell dose in unrelated BMT for hematological malignancies: a report from Japan marrow donor program

“…Calculated with the published data, 26 1 Â 10 8 /kg nucleated BM cells include 8 Â 10 6 /kg T cells, 3 Â 10 6 /kg B cells and 2 Â 10 6 /kg nature killer cells. Considering the cell dose used in adaptive immunotherapies with these cells, [27][28][29] this number of T cells can alter the outcome but that of nature killer cells will not. Therefore, we speculated that T cells would be the most likely population affecting relapse rates.…”

Natural killer cell immune escape in acute myeloid leukemia

“…This KIR-mediated recognition of missing self is the basis for donor-versus-recipient NK cell alloreactivity in KIR ligand-mismatched hematopoietic transplants in adult AML, which is extensively being investigated and reviewed by others. [6][7][8][9] Although also endogenous NK cells can target cancer cells and have been proven useful for cancer immunotherapy, 10,11 several hematological malignancies, [12][13][14] including AML, encompass significant impaired NK cell functions contributing to the escape of immune surveillance. In this review, we will discuss these mechanisms in AML, as well as strategies to restore NK-cellmediated anti-leukemia responses.…”