Use of nanocellulose in the intracellular delivery of biological and non-biological drugs: a review

Puppala, Navinchandra Venkata; Purnima, D.; Mohannath, Gireesha

doi:10.1007/s10570-022-04977-w

Cited by 5 publications

(3 citation statements)

References 106 publications

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“…The ability of nanocellulose to deliver biologics has not been explored much; therefore, some nanocellulose properties must be evaluated to choose the better type, since it will depend on the size and shape, charge, chemical composition and hydrophilicity of the molecule to be delivered. The subject is still new [ 134 ] and requires knowledge on the extraction and synthesis methods of the nanocellulose obtained, in order to choose the appropriate type to the delivery of biologics using nanocellulose.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review

Garcia,

Beck,

Brandalise

et al. 2024

Pharmaceutics

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The use of nanocellulose in pharmaceutics is a trend that has emerged in recent years. Its inherently good mechanical properties, compared to different materials, such as its high tensile strength, high elastic modulus and high porosity, as well as its renewability and biodegradability are driving nanocellulose’s industrial use and innovations. In this sense, this study aims to conduct a search of patents from 2011 to 2023, involving applications of nanocellulose in pharmaceuticals. A patent search was carried out, employing three different patent databases: Patentscope from World Intellectual Property Organization (WIPO); Espacenet; and LENS.ORG. Patents were separated into two main groups, (i) nanocellulose (NC) comprising all its variations and (ii) bacterial nanocellulose (BNC), and classified into five major areas, according to their application. A total of 215 documents was retrieved, of which 179 were referred to the NC group and 36 to the BNC group. The NC group depicted 49.7%, 15.6%, 16.2%, 8.9% and 9.5% of patents as belonging to design and manufacturing, cell culture systems, drug delivery, wound healing and tissue engineering clusters, respectively. The BNC group classified 44.5% of patents as design and manufacturing and 30.6% as drug delivery, as well as 5.6% and 19.4% of patents as wound healing and tissue engineering, respectively. In conclusion, this work compiled and classified patents addressing exclusively the use of nanocellulose in pharmaceuticals, providing information on its current status and trending advancements, considering environmental responsibility and sustainability in materials and products development for a greener upcoming future.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review

Garcia,

Beck,

Brandalise

et al. 2024

Pharmaceutics

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“…Nanocellulose as a versatile platform for drug delivery applications. 169,204,209,210 Bone tissue engineering 1. Nanocellulose-based scaffolds for bone tissue engineering.…”

Section: Biomedical Application Recent Studymentioning

confidence: 99%

Evaluation of inherent properties of the carboxymethyl cellulose (CMC) for potential application in tissue engineering focusing on bone regeneration

Mehrabi,

Jalise,

Hivechi

et al. 2023

Polymers for Advanced Techs

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Biomaterials are essential in medicine because these biological macromolecules have appropriately replaced classical tissue grafting techniques for their valuable features. Bone tissue engineering has persistently developed since “tissue engineering” was suggested. Carboxymethyl cellulose (CMC) is the first FDA‐approved water‐soluble derivative of cellulose that could be targeted for desired bone tissue graft. Numerous studies on CMC as a component created for bone tissue have recently been published. Because of its carboxylate groups, CMC is hydrophilic. CMC can crosslink with varied materials, such as synthetic and natural polymers, enabling innovative bone structure biomaterials. These carboxylate groups are responsible for in situ gelations and bio‐adhesion characteristics. In this review, the current progress and inherent characteristics of CMC‐based bone scaffold materials are discussed.

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“…It can promote wound healing by providing a moist environment, preventing infection, and facilitating the migration and proliferation of skin cells [71]. Other researchers have used nanocellulose as a carrier for controlled drug delivery [72]. Its high surface area and ability to encapsulate and release therapeutic agents in a controlled manner make it an ideal material for targeted and sustained drug delivery systems.…”

Section: Applications Of Nanocellulosementioning

confidence: 99%

The Role of Microorganisms in the Isolation of Nanocellulose from Plant Biomass

Yahya,

Elarbash,

Bairwan

et al. 2023

Forests

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The isolation and bottom-up assembly of nano-cellulose by using microorganisms offers unique advantages that fine-tune and meet the main key design criteria of sustainability, rapid renewability, low toxicity and scalability for several industrial applications. As a biomaterial, several properties are required to maintain the quality and functional period of any product. Thus, researchers nowadays are extensively using microorganisms to enhance the yield and properties of plant nanocellulose. A microbial process requires approximately 20%–50% less energy compared to the chemical isolation process that consumes high energy due to the need for intense mechanical processing and harsh chemical treatments. A microbial process can also reduce production costs by around 30%–50% due to the use of renewable feedstocks, fewer chemical additives, and simplified purification steps. A chemical isolation process is typically more expensive due to the extensive use of chemicals, complex processing steps, and higher energy requirements. A microbial process also offers higher yields of nanocellulose with well-defined and uniform dimensions, leading to improved mechanical properties and enhanced performance in various applications, compared with the chemical isolation process, which may result in a wider range of nanocellulose sizes, potentially leading to variations in properties and performance. The present review discusses the role of different microorganisms (bacteria, yeasts and fungi) in the isolation and production of nanocellulose. The types and properties of nanocellulose from different sources are also discussed to show the main differences among them, showing the use of microorganisms and their products to enhance the yield and properties of nanocellulose isolation. Finally, the challenges and propositions regarding the isolation, production and enhancement the quality of nanocellulose are addressed.

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Use of nanocellulose in the intracellular delivery of biological and non-biological drugs: a review

Cited by 5 publications

References 106 publications

Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review

Nanocellulose, the Green Biopolymer Trending in Pharmaceuticals: A Patent Review

Evaluation of inherent properties of the carboxymethyl cellulose (CMC) for potential application in tissue engineering focusing on bone regeneration

The Role of Microorganisms in the Isolation of Nanocellulose from Plant Biomass

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