Use of multiple colorimetric indicators for paper-based microfluidic devices

Dungchai, Wijitar; Chailapakul, Orawon; Henry, Charles S.

doi:10.1016/j.aca.2010.06.019

Cited by 319 publications

(228 citation statements)

References 34 publications

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“…Detection has mainly been carried out using colorimetric assays for off-site analysis via the ubiquitous smartphone [9,10]; however, electrochemical detection has also been investigated [11,12]. Several reviews are available [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Rapid evaporation-driven chemical pre-concentration and separation on paper

Syms

2017

Biomicrofluidics

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Airflow-enhanced evaporation is investigated as a method for rapid chemical pre-concentration on a thin porous substrate. The mechanism is described by combining 1D models of capillary rise, chromatography and pervaporation concentration. It is shown that the effective length of the column can be shorter than its actual length, allowing concentrate to be held at a stagnation point and then released for separation, and that the Péclet number, which determines concentration performance, is determined only by the substrate properties. The differential equations are solved dynamically, and it is shown that faster concentration can be achieved during capillary filling.Experiments are carried out using chromatography paper in a ducted airflow and concentration is quantified by optical imaging of water-soluble food dyes. Good agreement with the model is obtained, and concentration factors of ≈ 100 are achieved in 10 mins using Brilliant Blue FCF.Partial separation of Brilliant Blue from Tartrazine is demonstrated immediately following concentration, on a single un-patterned substrate. The mechanism may provide a method for improving the sensitivity of lab-on-paper devices.

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Section: Introductionmentioning

confidence: 99%

Rapid evaporation-driven chemical pre-concentration and separation on paper

Syms

2017

Biomicrofluidics

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“…The LOD of our nitrite assay was similar to the LOD of PADs (LOD = 0.005 mM) and 5.6 times lower than the LOD of poly(dimethylsiloxane) (PDMS)-based analytical devices (LOD = 0.045 mM) [25,26]. The LOD of our glucose assay was compatible for the current criteria of urine glucose, was better than the LOD of PADs (which could only recognize glucose levels above 0.5 mM), and was 7 times lower than the LOD of PDMS-based analytical devices (LOD = 0.56 mM) [27,28]. We thus believe that integrating color contrast into our platform design significantly improves the LODs of colorimetric assays and readily facilitates identification of results via the naked eye.…”

Section: Nitrite and Glucose Assaysmentioning

confidence: 99%

Calligraphy paper-based analytical devices

Kuan¹,

Chen²,

Hung³

et al. 2017

Point-of-Care Diagnostics - New Progresses and Perspectives

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“…[1][2][3][4][5] A number of μPAD fabrication methods have been developed to define hydrophilic microchannels on μPADs, including photolithography, 6,7 plasma-etching, 8 wax-printing, [9][10][11] plotting, 12 screen-printing, 13,14 contact stamping, [15][16][17] cutting, [18][19][20] and laminating, 21,22 among others. Each fabrication method has its own advantages and limitations.…”

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confidence: 99%

3,3′,5,5′-Tetramethylbenzidine Oxidation on Paper Devices for Horseradish Peroxidase-based Assays

et al. 2016

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We report on the colorimetric oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by hydrogen peroxide using horseradish peroxidase on photolithography-fabricated (P-PAD) and wax-printed (W-PAD) paper-based analytical devices. Fabricating PADs via photolithography exposes the hydrophilic areas to polymers (photoresists) and solvents, not only reducing the hydrophilicity, but also affecting the TMB-H2O2 assay system with an unavoidable incomplete elimination of photoresist during fabrication. Detection signals are then observed in the presence of photoresist residues on the P-PAD, even at a blank HRP concentration.

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Use of multiple colorimetric indicators for paper-based microfluidic devices

Cited by 319 publications

References 34 publications

Rapid evaporation-driven chemical pre-concentration and separation on paper

Rapid evaporation-driven chemical pre-concentration and separation on paper

Calligraphy paper-based analytical devices

3,3′,5,5′-Tetramethylbenzidine Oxidation on Paper Devices for Horseradish Peroxidase-based Assays

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