Use of Mouthwash and Dentifrice Containing an Antimicrobial Phthalocyanine Derivative for the Reduction of Clinical Symptoms of Covid-19: A Randomized Triple-Blind Clinical Trial

Poleti, Marcelo Lupion; Gregorio, Danielle; Bistaffa, Alisson Gabriel Idelfonso; Fernandes, Karen Barros Parron; Vilhena, Fabiano Vieira; Santos, Paulo Sérgio da Silva; Simão, Andréa Name Colado; Lozovoy, Marcell Alysson Batisti; Tatibana, Berenice Tomoko; Fernandes, Thaís Maria Freire

doi:10.1016/j.jebdp.2022.101777

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…After the title and abstract screening, the duplicates were removed, and 50 articles remained for full-text analysis. After full-text analysis, 36 were eliminated: 6 for not being a randomized trial [ 44 , 45 , 46 , 47 ], 3 for being an in vitro study [ 48 , 49 , 50 ], 17 for not having quantitative data of viral load [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ], 3 for not being in the oral cavity [ 68 , 69 , 70 ], 5 for not being a mouth rinse [ 71 , 72 , 73 , 74 , 75 ], and 2 for being a summary protocol [ 76 , 77 ]. Finally, 14 articles were selected for data extraction [ 12 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ,…”

Section: Resultsmentioning

confidence: 99%

Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review

Ting,

Dahlkemper,

Schwartz

et al. 2023

Biomedicines

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(1) There are limited clinical trials to support the effectiveness of mouth rinses when used as a preprocedural rinse against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This systematic review aims to evaluate the efficacy of antiseptic mouth rinses as a preprocedural rinse in reducing SARS-CoV-2 oral viral load in-vivo. (2) Methods: A literature search was conducted through November 2022 for the following databases: PubMed, Web of Science, Cochrane Library, and Google Scholar. The evaluated outcomes were quantitative changes in viral load and the statistical significance of that change after using antiseptic mouth rinses. (3) Results: 14 randomized controlled trials (RCT) were selected for risk of bias assessment and data extraction. (4) Conclusion: Within the limits of this systematic review, preprocedural mouth rinses may significantly reduce SARS-CoV-2 in the mouth, thus, reducing the viral particles available for airborne dispersion. Preprocedural mouth rinses may be an effective strategy for reducing airborne SARS-CoV-2 dispersion in the environment. Their use may be a preventive strategy to reduce the spread of COVID-19 in selected medical and healthcare facilities, including dental clinics. Potential preprocedural mouth rinses are identified for use as an integral part of safe practice for healthcare protocols. This systematic review was registered with the National Institute for Health Research, international prospective register of systematic reviews (PROSPERO): CRD42022315177.

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Section: Resultsmentioning

confidence: 99%

Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review

Ting,

Dahlkemper,

Schwartz

et al. 2023

Biomedicines

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show abstract

“…The Centers for Disease Control and Prevention (CDC) has advocated the benefits of preprocedural mouthwashes in reducing airborne pathogens of all types before clinical procedures [ 28 ]. Studies by Bernardo da Fonseca Orcina [ 29 ] and Marcelo Lupion Poleti et al [ 30 ] indicated that mouthwashes containing antimicrobial phthalocyanine derivative (APD) had been found to have a positive impact on the relief of early clinical symptoms of patients with COVID-19, such as sore throat, cough, and mouth ulcers.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis

Zhang,

Meng,

Duo

et al. 2023

BMC Infect Dis

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Background COVID-19 has been a public health emergency of international concern (PHEIC) for a lengthy period of time. The novel coronavirus is primarily spread via aerosols at a short distance, with infected individuals releasing large amounts of aerosols when speaking and coughing. However, there is an open question regarding whether mouthwash could effectively reduce virus transmission during the COVID-19 pandemic and support the prevention of infection among medical workers. Methods Cochrane Library, PubMed, Web of Science, and Embase databases were systematically searched from the inception of each database to January 12, 2023 for currently available randomized clinical trials (RCTs) on the effect of mouthwash on novel coronavirus load in the oral cavity in COVID-19 patients. The treatment group received mouthwash for rinsing the mouth, while the control group received a placebo or distilled water for COVID-19 patients. The primary outcomes were CT value and viral load. Odds ratios (ORs) were estimated using a random-effects model. Subgroup and sensitivity analyses were performed to minimize the bias and the impact of heterogeneity. Results Thirteen RCTs were included. Seven studies reported the intervention effect of mouthwash on the CT value of novel coronavirus. The analysis results showed that the mouthwash group had a positive impact on the CT value of novel coronavirus [ SMD = 0.35, 95% CI (0.21, 0.50)] compared with the control group. In addition, subgroup analysis showed a significant positive effect of mouthwash on CT values in the treatment group compared with the control group, with chlorhexidine (CHX) [SMD = 0.33, 95% CI (0.10, 0.56)], povidone-iodine (PVP-I) [SMD = 0.61, 95% CI (0.23, 0.99)], or hydrogen peroxide (HP) [SMD = 1.04, 95% CI (0.30, 1.78)] as an ingredient of the mouthwash. Six studies reported the intervention effect of mouthwash on the viral load, 263 cases in the treatment group and 164 cases in the control group. The analysis results showed that there was no statistical difference between the mouthwash group and the control group in the viral load of novel coronavirus [SMD = -0.06, 95% CI (-0.18, 0.05)]. In the subgroup analysis by measurement time, there were statistically significant differences between the mouthwash and control groups for CT values [SMD = 0.52, 95% CI (0.31, 0.72)] and viral load [SMD = − 0.32, 95% CI (− 0.56, − 0.07)] within 30 min of gargling. Conclusions In summary, mouthwash has some efficacy in reducing the viral load of novel coronavirus, especially within 30 min after rinsing the mouth. Mouthwash containing CHX, PVP-I and HP all had significant positive effects on CT values, and PVP-I-containing mouthwash may be a promising option to control novel coronavirus infections and relieve virus-related symptoms. However, studies on the dose and frequency of use of mouthwash for infection control are still lacking, which may limit the clinical application of mouthwash. Trial registration Protocol registration: The protocol was registered at PROSPERO (CRD42023401961).

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Development and validation of convective‐diffusion models to analyse the transient behaviour of a packed bed: Factors influencing aqueous phase adsorption of a bisbiguanide

Banerjee¹,

Pal²,

Sarkar³

et al. 2023

Journal of Hazardous Materials Advances

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Use of Mouthwash and Dentifrice Containing an Antimicrobial Phthalocyanine Derivative for the Reduction of Clinical Symptoms of Covid-19: A Randomized Triple-Blind Clinical Trial

Cited by 4 publications

References 33 publications

Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review

Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review

Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis

Development and validation of convective‐diffusion models to analyse the transient behaviour of a packed bed: Factors influencing aqueous phase adsorption of a bisbiguanide

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