Use of modified ciclosporin in the management of feline pemphigus foliaceus: a retrospective analysis

Irwin, Katherine; Beale, Karin M.; Fadok, Valerie A.

doi:10.1111/j.1365-3164.2012.01069.x

Cited by 25 publications

(43 citation statements)

References 29 publications

(88 reference statements)

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“…There is one study reporting a cat with cutaneous xanthomas and concurrent demodicosis and dermatophytosis . The development of concurrent dermatophytosis in cats receiving immunosuppressive drugs for the treatment of pemphigus foliaceus was not reported in either of two large studies . One cat developed M. canis dermatophytosis while receiving ciclosporin for treatment of pseudopelade …”

Section: Disease Overviewmentioning

confidence: 99%

Diagnosis and treatment of dermatophytosis in dogs and cats.

Moriello

Coyner²,

Paterson

et al. 2017

Veterinary Dermatology

225

147

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Background -Dermatophytosis is a superficial fungal skin disease of cats and dogs. The most common pathogens of small animals belong to the genera Microsporum and Trichophyton. It is an important skin disease because it is contagious, infectious and can be transmitted to people.Objectives -The objective of this document is to review the existing literature and provide consensus recommendations for veterinary clinicians and lay people on the diagnosis and treatment of dermatophytosis in cats and dogs. Conclusions -No one diagnostic test was identified as the gold standard. Successful treatment requires concurrent use of systemic oral antifungals and topical disinfection of the hair coat. Wood's lamp and direct examinations have good positive and negative predictability, systemic antifungal drugs have a wide margin of safety and physical cleaning is most important for decontamination of the exposed environments. Finally, serious complications of animal-human transmission are exceedingly rare. Methods - Clinical Consensus GuidelinesClinical Consensus Guidelines (CCGs) provide the veterinary community with current information on the pathophysiology, diagnosis and treatment of commonly encountered dermatological conditions. The World Association for Veterinary Dermatology (WAVD) oversees selection of relevant topics, identification of panel members possessing the expertise to draft the Clinical Consensus Guidelines, and any other aspects required to assure the integrity of the process. The statements are derived from evidence-based medicine whenever possible, however when such evidence does not exist then expert opinions would be utilized by the members of the panel. A draft is prepared by the panel, followed by a presentation of the guidelines at major national and/or international veterinary meetings. Access to the guidelines will be available on the WAVD web site. Solicitation for input from WAVD member organizations and affiliate and provisional member groups will result in the incorporation of this feedback into the guidelines. The final CCG manuscript will be submitted to the Veterinary Dermatology journal, where it is reviewed and edited before publication. The authors are solely responsible for the content of the statements.

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Section: Disease Overviewmentioning

confidence: 99%

Diagnosis and treatment of dermatophytosis in dogs and cats.

Moriello

Coyner²,

Paterson

et al. 2017

Veterinary Dermatology

225

147

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“…Several studies have investigated the use of oral ciclosporin A (CsA) in cats with various skin disorders; the efficacy and safety of CsA for the treatment of feline allergic dermatoses has been reported in double‐blinded and randomized controlled trials . Additionally, CsA has been reported in retrospective and case series reports to be effective for other feline dermatological conditions including eosinophilic granuloma complex, urticaria pigmentosa, plasmacytic stomatitis, acquired alopecia (pseudopelade), pemphigus complex, idiopathic pruritus and dirty face syndrome of Persian cats . Mild adverse effects have been reported with oral CsA administration in cats, including hypersalivation, headshaking, vomiting, soft faeces, diarrhoea and gingival hyperplasia .…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous administration of ciclosporin in 11 allergic cats – a pilot open‐label uncontrolled clinical trial

Koch

Torres

Diaz

et al. 2017

Veterinary Dermatology

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“…In these cases, a dose of 5 mg/kg SID PO in the dog and 7 mg/kg PO SID in the cat has been used. Ciclosporin is used in a variety of IMDs, and in pemphigus and the auto‐immune sub‐epidermal blistering diseases it is best used when the acute phase of the disease has been treated by other means (Irwin et al, ), whereas in alopecia areata, pseudopelade and sebaceous adenitis (SA), it can be used as a sole agent. In SA there is a marked improvement in many cases that are treated early enough, although after chronic therapy, areas of alopecia may return.…”

Section: Ciclosporinmentioning

confidence: 99%