Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity

Abstract

Objective: To check the ability of microperimetry to detect early retinal damage in rheumatic patients taking hydroxychloroquine (HCQ) and/or chloroquine (CQ). To describe the microperimetric alterations attributable to these drugs and their correlation with some clinical variables. Results: Significant differences in microperimetry indexes were detected between cases and controls, between patients of different age groups, and between patients taking CQ and HCQ. Significant differences were also detected in retinal sensitivity between patients overdosed for CQ but not for those overdosed for HCQ. Daily overdosing per ideal weight alone cannot explain retinal toxicity, although the effect of cumulative dose in macular sensibility is significant to explain both AT and MI. Conclusions:Microperimetry is an accurate tool for detecting early macular hyposensibility caused by CQ and HCQ. Microperimetry indexes of retinal sensibility are worse in elderly patients taking these drugs, and in 2 short stature patients taking CQ. A high cumulative dose is an important factor in explaining retinal hyposensibility on microperimetry.3

Value of Microperimetry in Detecting Early Retinal Toxicity of Hydroxychloroquine in Children with Juvenile Systemic Lupus Erythematosus

“…These results were contradictory to the results of two studies [7,8] that were conducted in 2013 and used microperimetry as a novel screening test for retinal toxicity caused by antimalarial drugs. Both studies concluded that microperimetry, though not being a recommended test of screening, could provide important information regarding visual function in patients on HCQ therapy [7,8].…”

“…Both studies concluded that microperimetry, though not being a recommended test of screening, could provide important information regarding visual function in patients on HCQ therapy [7,8].…”

Detección precoz de toxicidad retiniana por antipalúdicos. Estudio con microperimetría y OCT

“…Es un dato difícil de analizar de manera aislada. Es muy dependiente del factor aprendizaje por lo que el resultado puede no ser fiable 67 .…”

“…Nosotros encontramos a 3 pacientes con depósitos corneales de los cuales 2 presentaban maculopatía 67 .…”

“…Además, en estos individuos existía una diferencia en la IM de ambos ojos que no se producía en los pacientes. Serían necesarios estudios prospectivos más amplios para evaluar si el índice de IM es válido para muestras de pacientes afectos de maculopatías diferentes a la degeneración macular senil 67,79 .…”