Use of micronized natural progesterone as preparation for assisted reproductive technologies in patients with uterine infertility factor

Булгакова, В. П.; Боровиков, И. О.

doi:10.17116/repro20182406167

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Progesterone reduces ER-α levels, increases expression of progesterone receptors, thereby increasing sensitivity of the endometrium to progesterone and endometrial receptivity. In contrast to the proliferative effect of estrogen, progesterone action promotes differentiation of endometrial tissue inactivating estradiol through stromal progesterone receptors, emergence and maturation of pinopodia, ensures preparation of the endometrium for embryo implantation [ 81 ]. Progestins increase not only endometrial receptivity but also its thickness, which is an important factor in ensuring successful embryo implantation [ 82 , 83 ].…”

Section: Clinical Use Of Gestagensmentioning

confidence: 99%

Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review)

Федотчева

2021

Sovrem Tehnol Med

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This review summarizes the current opinions on the mechanisms of action of nuclear, mitochondrial, and membrane progesterone receptors. The main aspects of the pharmacological action of progestins have been studied. Data on the clinical use of gestagens by nosological groups are presented. Particular attention is paid to progesterone, megestrol acetate, medroxyprogesterone acetate due to broadening of their spectrum of action. The possibilities of using gestagens as neuroprotectors, immunomodulators, and chemosensitizers are considered.

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Section: Clinical Use Of Gestagensmentioning

confidence: 99%

Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review)

Федотчева

2021

Sovrem Tehnol Med

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Preparation for in vitro fertilization of patients with a «thin» endometrium — the possibilities of cytokine therapy

Borovikov,

Bulgakova,

Borovikova

et al. 2023

Probl. reprod.

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Complex method of preparation for <i>in vitro</i> fertilization of patients with intrauterine synechia

Abramova,

Taits,

Pugacheva

et al. 2024

Pediatr (SPb)

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BACKGROUND: Intrauterine synechiae (Ascherman syndrome) is one of the fairly common causes of infertility. Despite a large number of clinical studies, there are still no effective methods of both prevention and treatment, which is one of the main causes of reproductive failures. The article discusses the experience of combined preimplantation preparation of patients with uterine factor infertility caused by intrauterine synechia. An assessment of the effectiveness of preparation for the in vitro fertilization procedure, with subendometrial use of platelet-rich autoplasma against the background of surgical, antibacterial and hormone therapy, is given. AIM: Evaluation of the effectiveness of complex preimplantation preparation of patients with uterine factor infertility caused by intrauterine synechia. MATERIALS AND METHODS: Study of the results of preparation for in vitro fertilization with thawed embryos of 30 women with infertility against the background of Asherman’s syndrome. Treatment: surgical (hysteroscopic adhesiolysis), antibiotic therapy (semisynthetic penicillin’s with clavulanic acid), hormonal support (conjugated estradiol valerate and micronized progesterone) and subendometrial administration of platelet-rich autoplasma. The main criterion for the effectiveness of treatment is the onset of biochemical and clinical pregnancy. RESULTS: The method of combined preimplantation preparation of infertile patients with intrauterine synechia showed high efficiency of the in vitro fertilization procedure: the onset of clinical pregnancy in 46.7% of women, live birth in 36.7%. CONCLUSIONS: A comprehensive method of preparation for in vitro fertilization of patients with intrauterine synechiae significantly increases the chances of successful embryo implantation during this procedure.

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Use of micronized natural progesterone as preparation for assisted reproductive technologies in patients with uterine infertility factor

Cited by 6 publications

References 15 publications

Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review)

Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review)

Preparation for in vitro fertilization of patients with a «thin» endometrium — the possibilities of cytokine therapy

Complex method of preparation for <i>in vitro</i> fertilization of patients with intrauterine synechia

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