Use of microextraction by packed sorbents and gas chromatography-mass spectrometry for the determination of polyamines and related compounds in urine

Current trends on microextraction by packed sorbent – fundamentals, application fields, innovative improvements and future applications

“…Analyst pathological conditions. Regarding this, it is very interesting to verify that different biogenic amines extracted from plasma and urine using MEPS were analysed using distinct approaches such as HILIC-MS, PTV-GC-MS and CLC-MS. 42,43 This is also indirect evidence of the wide compatibility of MEPS with different analytical methodologies. These reports highlight the broad usage and potential of MEPS extraction in the analytical layout supporting pharmaceutical and clinical analysis.…”

“…Finally, the online and fully automatic MEPS approaches using autosamplers are still very expensive and in the last five years only two applications using this format were reported. 42,67 In MEPS operation, the samples and solvents are loaded and discarded through the same channel. This may be particularly critical for target analytes with weak interactions with the sorbent.…”