Use of metformin in polycystic ovary syndrome

Adipose tissue and reproduction in women

“…The possible increased risk of first-trimester miscarriages and gestational diabetes in women with PCOS has been related to increased PAI-1 activity and elevated plasma levels of PAI-1 (456,456). Glueck et al (455) found more PAI-1 gene 4G polymorphisms and an increase in PAI-1 activity in women with PCOS compared with control women, a finding that was also demonstrated in a recent meta-analysis (457).…”

Effect of a low glycemic index compared with a conventional healthy diet on polycystic ovary syndrome

“…Metformin, an insulin-sensitizing agent that is commonly prescribed for women with PCOS, was shown to improve both metabolic and reproductive variables (42)(43)(44). However, it is not clear if metformin use has benefits over and above dietary and lifestyle change (41,(45)(46)(47)(48).…”

Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012

“…We excluded patients with a history of diabetes in year 1 ( n = 9606), those who were not aged 19 to 58 years in year 1 ( n = 8006) because national guidelines highlight evidence for metformin use in patients younger than 60 years, and women with a history of the polycystic ovary syndrome ( n = 258) because metformin can be prescribed for reasons other than diabetes prevention in this group (for example, oligomenorrhea and infertility) (19–21). We also excluded those who were pregnant ( n = 426) because metformin is classified under U.S. Food and Drug Administration pregnancy category B, as well as those with an elevated creatinine level (defined as ≥132.6 μmol/L [1.5 mg/dL] for men and ≥123.8 μmol/L [1.4 mg/dL] for women [ n = 262]) because renal insufficiency is a contraindication to metformin use.…”