Use of metal-based contrast agents for in vivo MR and CT imaging of phagocytic cells in neurological pathologies

Advancing MRI with magnetic nanoparticles: a comprehensive review of translational research and clinical trials

“…While the latter presents nonspecific inflammation data that only evaluates the integrity of the blood–brain barrier (BBB), the former is taken up directly by macrophages and can additionally identify their content and infiltration degree. 35 Several studies in multiple sclerosis patients have proven the ability of ferumoxtran-10, when compared with Gd-enhanced MRI, to find new active lesions not detected by Gd and pinpoint lesions with aggressive behaviour, that are enhanced by both contrast agents. 36 In the future, this dual technique should find it's way to clinical practice, although at this time the clinical studies are still in phase 1.…”

Advances in the application of manganese dioxide and its composites for theranostics

“…With rapid advancements in nanotechnology, MITs including photoacoustic imaging (PA), 18 fluorescence (FL) imaging, 19 single-photon emission computed tomography, 20 optical microscopy, 21 positron emission computed tomography 22 and magnetic resonance imaging (MRI), 23 have attracted significant attention based on nanometer-scale contrast agents. Among them, MRI contrast agents can provide anatomical structures and pathology with a high spatial resolution, [24][25][26] these agents are used in the fields of inflammation detection, 27 fibrosis diagnosis, 28 thromboembolic disease imaging 29 and cancer therapy. 30 Furthermore, the role of photoacoustic imaging and fluorescence imaging in disease diagnosis is paramount.…”

Neuroengineering: ferromagnetic nano (micro) implants. Magnetic-hypnotic effect control of animal behavior by an external magnetic field

“…Active magnetic particles in vivo are the subject of research into the possibility of their influence on molecular and physiologically significant structures of the human and animal body [7][8][9][10][11][12][13]. In medical practice, gadolinium derivatives and nano-(micro)magnetic particles (Fe 3 O 4 ) have long been used as contrast agents in the magnetic resonance imaging [14][15][16].…”