“…While the latter presents nonspecific inflammation data that only evaluates the integrity of the blood–brain barrier (BBB), the former is taken up directly by macrophages and can additionally identify their content and infiltration degree. 35 Several studies in multiple sclerosis patients have proven the ability of ferumoxtran-10, when compared with Gd-enhanced MRI, to find new active lesions not detected by Gd and pinpoint lesions with aggressive behaviour, that are enhanced by both contrast agents. 36 In the future, this dual technique should find it's way to clinical practice, although at this time the clinical studies are still in phase 1.…”
Section: Next-generation Magnetic Nanoparticles In Mri: Translating R...mentioning
The nexus of advanced technology and medical therapeutics has ushered in a transformative epoch in contemporary medicine. Within this arena, Magnetic Resonance Imaging (MRI) emerges as a paramount tool, intertwining...
“…While the latter presents nonspecific inflammation data that only evaluates the integrity of the blood–brain barrier (BBB), the former is taken up directly by macrophages and can additionally identify their content and infiltration degree. 35 Several studies in multiple sclerosis patients have proven the ability of ferumoxtran-10, when compared with Gd-enhanced MRI, to find new active lesions not detected by Gd and pinpoint lesions with aggressive behaviour, that are enhanced by both contrast agents. 36 In the future, this dual technique should find it's way to clinical practice, although at this time the clinical studies are still in phase 1.…”
Section: Next-generation Magnetic Nanoparticles In Mri: Translating R...mentioning
The nexus of advanced technology and medical therapeutics has ushered in a transformative epoch in contemporary medicine. Within this arena, Magnetic Resonance Imaging (MRI) emerges as a paramount tool, intertwining...
“…With rapid advancements in nanotechnology, MITs including photoacoustic imaging (PA), 18 fluorescence (FL) imaging, 19 single-photon emission computed tomography, 20 optical microscopy, 21 positron emission computed tomography 22 and magnetic resonance imaging (MRI), 23 have attracted significant attention based on nanometer-scale contrast agents. Among them, MRI contrast agents can provide anatomical structures and pathology with a high spatial resolution, [24][25][26] these agents are used in the fields of inflammation detection, 27 fibrosis diagnosis, 28 thromboembolic disease imaging 29 and cancer therapy. 30 Furthermore, the role of photoacoustic imaging and fluorescence imaging in disease diagnosis is paramount.…”
Manganese dioxide (MnO2), a type of redox-active transition-metal dioxide, has found wide applications as catalysts, oxidants, ferrites, achromats, contrast agents and batteries material. In addition, MnO2 is also increasingly being...
“…Active magnetic particles in vivo are the subject of research into the possibility of their influence on molecular and physiologically significant structures of the human and animal body [7][8][9][10][11][12][13]. In medical practice, gadolinium derivatives and nano-(micro)magnetic particles (Fe 3 O 4 ) have long been used as contrast agents in the magnetic resonance imaging [14][15][16].…”
A method of injecting barium hexaferrite-based ferromagnetic implants into the brain of animals is proposed. Behavioral responses of mice to external magnetic influence after the introduction of non-toxic nanomagnetic particles of barium hexaferrite were studied. A decrease in the BOLD-signal value at nitric oxide "outflow" within the framework of the proposed kinetic model was shown.
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