Use of Mesalazine for the Determination of Dopamine and Its Pharmaceutical Preparations by Spectrophotometric Method

Nejres, Aws Maseer; Najem, Moath A.

doi:10.52865/avwr7365

Cited by 4 publications

(2 citation statements)

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“…To investigate the accuracy and precision of the proposed method, an aliquot (7 and 15 µg/mL) concentration of ALP and LSD, each concentration, was repeated three times individually (Table 4). The recovery% and error% were calculated as accuracy and the relative standard deviation as precision [20].…”

Section: Accuracy and Precision Of The Proposed Methodsmentioning

confidence: 99%

Simultaneous determination of amlodipine and lisinopril dihydrate using fourth derivative spectroscopy

Nejres

Najem

2023

Eur J Chem

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A new fast and simple selective method for the simultaneous determination of lisinopril dihydrate and amlodipine in combined drugs was developed using the fourth derivative spectrum method, based on the zero-crossing-point technique for the determination of compounds in drugs. The wavelength values for lisinopril dihydrate and amlodipine in solvent medium were found to be (203, 207, and 231 nm) and (215, 254, and 277 nm), respectively, with the average obeying Beer’s law in the range of lisinopril dihydrate 2.0 to 45.0 µg/mL and amlodipine 2.0 to 35.0 µg/mL. Lisinopril dihydrate has molar absorptivity regions (9227.76-11700.28 L/mol.cm, 203 nm), (15320.74-20795.59 L/mol.cm, 207 nm), and (2207.60-3311.40 L/mol.cm, 231 nm), while amlodipine (5886.72-10914.96 L/mol.cm, 215 nm), (5518.8-6418.16 L/mol.cm, 254 nm) and (1676.08-1921.36 L/mol.cm, 277 nm). The recovery rate of lisinopril dihydrate in the pharmaceutical dosage forms range was 95.13 to 102.60% and amlodipine 95.14 to 102.80%. The results of the relative error showed that the interferences did not affect the method of estimating these compounds. The proposed method has been successfully applied to estimate pharmaceutical dosage forms.

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Section: Accuracy and Precision Of The Proposed Methodsmentioning

confidence: 99%

Simultaneous determination of amlodipine and lisinopril dihydrate using fourth derivative spectroscopy

Nejres

Najem

2023

Eur J Chem

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“…The suggested method's applicability for determining MZN in drugs was investigated by investigating two pharmaceuticals (Pentasa Germany and Pentasa Turkey) applied at ( 2.5 and 3.75 μg.mL -1 ) with four replicates. Table 6 shows the results of determining MZN in pharmaceutical formulations, which were compared to the standard MZN and with British Pharmacopoeia [24] standard methods using t-test and F-test [25,26]. With degrees of freedom for four levels, it was shown in Table 6.…”

Section: Application Of Mzn In Pharmaceuticals Formulationsmentioning

confidence: 99%

Diazotizasyon ve Kuplaj Reaksiyonu ile Saf Form ve Farmasötik formülasyonlarda Mesalazin'in spektrofotometrik tayini

MASEER,

NAJEM

2023

HUJPHARM

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An accurate, simple, and precise spectrofluorimetric method is presented for the determination of Mesalazine (MZN) based on Diazotization in acidic medium through reaction it with Sodium nitrite (NaNO2) to result diazonium salt that Coupling Reaction in medium base with 2,7-Dihydroxynaphthalene (DHNP) to formed azo dye. The intensity of the dye was measured at 501 nm after optimization of the experimental parameters. Beer’s law was applied to the proposed method and it was valid within a concentration range of 0.25–10 μg/mL and the linear regression was R2 = 0.9974. The limit of quantitation was 0.0241 μg/mL, and the molar absorptivity coefficient 1.85x104 L.mol−1.cm−1. Sandal's sensitivity was 0.0082 μg.cm-2 There is no interference from excipients found in the tablet. The data were statistically compared with British Pharmacopoeia methods asstandard reference using Student's t-and F-test.

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Development of Spectrophotometric Method to Assay Phenylephrine Hydrochloride in Pure and in its Pharmaceutical Forms Using Diazotized Sulphanilic Acid

Hanan H.,

Mohammed

2024

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This work described a simple and sensitive spectrophotometric procedure for estimating phenylephrine hydrochloride in pure and in its pharmaceutical using diazotized sulphanilic acid as a coupling agent in alkaline medium of sodium carbonate solution. The resulting yellow azo-dye displayed an absorption maximum at 441 nm. The calibration graph was linear and compatible to Beer's law over the concentration range 0.2-20 µg/mL with coefficient estimated (r2=0.9996). The values of molar absorptivity and the sensitivity of Sandell's index were calculated and equal to 8.51×103 l/mol.cm and0.0239 µg/cm2, respectively. The values of detection limit (LOD), quantification limit (LOQ) and the range of relative error percentage were estimated and found to be 0.0050, 0.0166 µg/mL and -0.374% to -0.147%, respectively. The precision (represented by RSD) was also calculated and found to be in the range ±0.037 to ±0.28. The suggested procedure was useful successfully to the assay of phenylephrine hydrochloride in injection, drops and syrups. No interferences were observed from common additives found in pharmaceutical preparations. The yellow color of the product was highly stable and did not show a significant change in absorbance up to 60 min

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Use of Mesalazine for the Determination of Dopamine and Its Pharmaceutical Preparations by Spectrophotometric Method

Cited by 4 publications

References 0 publications

Simultaneous determination of amlodipine and lisinopril dihydrate using fourth derivative spectroscopy

Simultaneous determination of amlodipine and lisinopril dihydrate using fourth derivative spectroscopy

Diazotizasyon ve Kuplaj Reaksiyonu ile Saf Form ve Farmasötik formülasyonlarda Mesalazin'in spektrofotometrik tayini

Development of Spectrophotometric Method to Assay Phenylephrine Hydrochloride in Pure and in its Pharmaceutical Forms Using Diazotized Sulphanilic Acid

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