Use of Marine biotoxins to modulate the tyrosine kinase domain of the human epidermal growth factor receptor

Abstract

Inappropriate activation of the Epidermal growth factor receptor (EGFR) group of kinases has been identified in a variety of tumour cells, either due to mutation or overexpression. Although the tumour is a fatal disease, significant therapy discoveries have lately been made. The human EGFR and this family of kinases have emerged as promising targets for cancer therapy. In this molecular docking study, Natural marine toxins are employed to regulate the activity of the human EGFR tyrosine kinase domain (EGFRtkd) in the molecular docking investigation (PDB ID5JEB). Marine biotoxins can cause neurological, gastrointestinal, and cardiovascular problems, as well as severe mortality and long-term morbidity in some situations. Because there is no antidote for any of the natural marine poisons, supportive care is the mainstay of treatment. Paralytic shellfish poisoning, in particular, and puffer fish poisoning, in particular, can result in death within hours of exposure to the poisons and may require immediate medical intervention. However, this research found that marine biotoxins can modulate EGFRtkd. Furthermore, homoyessotoxin was anticipated to be an EGFRtkd modulator with a binding affinity as -9.584 kcal/mol. To employ the homoyessotoxin in tumour therapies, further knowledge of natural marine biotoxins and further toxicological research is required.

Gambierdiscus and Its Associated Toxins: A Minireview

“…Moreover, 20% of people affected may develop chronic ciguatera poisoning, and chronic weakness may last for years [ 151 ]. Despite some efforts, there is still no antidote for any natural marine toxin [ 152 ]. Transcriptome-level studies have been devoted to studying the effects of CTXs on mice, both in vitro and in vivo, as well as on the whole blood of patients [ 153 , 154 , 155 ].…”