Use of magnesium sulfate in continuous infusion in patients with severe acute asthma, in a pediatric emergency room

Abstract

Introduction Asthma is a chronic disease, of high prevalence, with important morbidity and that can lead to death in childhood. The use of intravenous magnesium sulfate has been indicated in cases refractory to the initial management with inhaled bronchodilators and corticosteroids. Objective To evaluate the use of magnesium sulfate in continuous infusion (50 mg/kg/h in 4 h) in children with severe acute asthma in a pediatric emergency room. Location Ten‐bed general pediatric emergency room, university hospital, tertiary, in southern Brazil. Patients All children over 2 years old with severe acute asthma refractory to the initial treatment who received a continuous infusion of magnesium sulfate at a dose of 50 mg/kg/h in 4 h, from April 2017 to October 2019. Conclusion Based on this study, the use of continuous intravenous magnesium sulfate proved to be well tolerated, leading to improved respiratory status, and can be considered as a satisfactory adjunctive therapy in the management of severe acute asthma.

Risk factors for hyponatremia in acute exacerbation chronic obstructive pulmonary disease (AECOPD): a multicenter cross-sectional study

“…Otherwise, lung function [forced vital capacity (FVC) and forced expiratory volume (FEV)] was improved by dietary magnesium intake [ 41 , 47 ]. Meanwhile, magnesium supplement was a promising and potential treatment for COPD and asthma [ 48 , 49 ]. Further studies with more focus on the role of magnesium on the prognosis and treatment of COPD is therefore suggested.…”

Pediatric pulmonology 2021 year in review: Asthma

“…However, few studies have been performed in children. Junior et al 11 conducted a prospective, cohort study to examine the use of continuous infusion of magnesium sulfate in a pediatric emergency department in Brazil. For 6 months, all children ( n = 40) over 2 years old with severe asthma exacerbations received a 50 mg/kg/h magnesium sulfate infusion for 4 h. They found that magnesium sulfate was well‐tolerated in these children and appeared to lead to improved respiratory status.…”