Use of macrophages to deliver therapeutic and imaging contrast agents to tumors

Choi, Jinhyang; Kim, Hye-Yeong; Ju, Eun Jin; Jung, Joohee; Park, Jaesook; Chung, Hye-Kyung; Lee, Jin Seong; Lee, Jung Shin; Park, Heon Joo; Song, Si Yeol; Jeong, Seong‐Yun; Choi, Eun Kyung

doi:10.1016/j.biomaterials.2012.02.022

Cited by 186 publications

(177 citation statements)

References 24 publications

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“…Similarly, uptake of liposomeencapsulated doxorubicin had a negative impact on the survival of murine peritoneal macrophages (Choi et al, 2012a). Others, who studied immune cell-mediated transport of liposomal drug formulations did not analyze cell viability (Ikehara et al, 2006) or showed only short-term survival data (Choi et al, 2012b).…”

Section: Discussionmentioning

confidence: 98%

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Blaudszun¹,

Lian²,

Schnabel³

et al. 2014

International Journal of Pharmaceutics

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Section: Discussionmentioning

confidence: 98%

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Blaudszun¹,

Lian²,

Schnabel³

et al. 2014

International Journal of Pharmaceutics

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“…Male Balb/c nude mice (5 weeks old) were purchased from SLC (Shizuoka, Japan) and were used to generate subcutaneous (sc) tumor mouse model as described in previous studies. 16,17 All experiments were performed following the protocol approved by the Institutional Animal Care and Use Committee of ASAN Institute for Life Science. To generate an sc tumor mouse model, 1×10…”

Section: Characterization Of Nufs-dtx Dispersion Solutionmentioning

confidence: 99%

Nanoparticulated docetaxel exerts enhanced anticancer efficacy and overcomes existing limitations of traditional drugs

Choi¹,

Ko²,

Chung³

et al. 2015

IJN

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Nanoparticulation of insoluble drugs improves dissolution rate, resulting in increased bioavailability that leads to increased stability, better efficacy, and reduced toxicity of drugs. Docetaxel (DTX), under the trade name Taxotere™, is one of the representative anticancer chemotherapeutic agents of this era. However, this highly lipophilic and insoluble drug has many adverse effects. Our novel and widely applicable nanoparticulation using fat and supercritical fluid (NUFS™) technology enabled successful nanoscale particulation of DTX (Nufs-DTX). Nufs-DTX showed enhanced dissolution rate and increased aqueous stability in water. After confirming the preserved mechanism of action of DTX, which targets microtubules, we showed that Nufs-DTX exhibited similar effects in proliferation and clonogenic assays using A549 cells. Interestingly, we observed that Nufs-DTX had a greater in vivo tumor growth delay effect on an A549 xenograft model than Taxotere™, which was in agreement with the improved drug accumulation in tumors according to the biodistribution result, and was caused by the enhanced permeability and retention (EPR) effect. Although both Nufs-DTX and Taxotere™ showed negative results for our administration dose in the hematologic toxicity test, Nufs-DTX showed much less toxicity than Taxotere™ in edema, paralysis, and paw-withdrawal latency on a hot plate analysis that are regarded as indicators of fluid retention, peripheral neuropathy, and thermal threshold, respectively, for toxicological tests. In summary, compared with Taxotere™, Nufs-DTX, which was generated by our new platform technology using lipid, supercritical fluid, and carbon dioxide (CO 2 ), maintained its biochemical properties as a cytotoxic agent and had better tumor targeting ability, better in vivo therapeutic effect, and less toxicity, thereby overcoming the current hurdles of traditional drugs.

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“…The second strategy was able to be successfully shown by binding magnetoliposome-antibody complexes to MN antigens of renal cell carcinoma cells [206], magnetoliposomeanti-Her2-AB to breast cancer cells [203], or anti-folate receptor-SPIO to different tumor cell lines [207]. The third strategy was able to be successfully proven on the basis of rhenium188-loaded immuno(hepama-1)magnetic nanoparticles (Re-SPIO-AB) against liver carcinoma cells [208], methotrexate-conjugated SPIO against breast (MCF7) and cervical (HeLa) carcinoma cells [209], doxorubicin-loaded nanomicelles [210], doxorubicin-carrying hyaluronan-SPIO (DOX-HA-SPIO) [211], docetaxel-carboxymethylcellulose-SPIO [212], layer-by-layer (LbL) polyelectrolyte capsules that can be loaded with SPIO and/or therapeutic agents [213], SPIO-and doxorubicin-loaded cetuximab-anti-EGFR immunomicelles or with doxorubicin(liposomal)-loaded macrophages (macrophage-LP-Dox) that accumulate in tumors [214]. Although major advances in tumor labeling and tumor therapy via therapeutic imaging SPIO constructs (theranostics) have been made in recent years, the development of potent in vivo theranostics with high specificity and sensitivity has remained a significant challenge due to the heterogeneity of the expression level of the target structure on the tumor cells and problems with overcoming physiological barriers (e. g. extravasation or blood-tissue barriers) preventing access to the target cell (pharmacological accessibility).…”

Section: Molecular Therapymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

120

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Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

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Use of macrophages to deliver therapeutic and imaging contrast agents to tumors

Cited by 186 publications

References 24 publications

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Polyester-idarubicin nanoparticles and a polymer-photosensitizer complex as potential drug formulations for cell-mediated drug delivery

Nanoparticulated docetaxel exerts enhanced anticancer efficacy and overcomes existing limitations of traditional drugs

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

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