Abstract:Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs were treated with a single oral dose of 0.5 or 2 mg/kg minoxidil or control vehicle, and M-mode and Doppler parameters were recorded at different time points before as well as 1, 3 and 24 h after tre… Show more
“…Moreover, ECG abnormalities in cats with MXT are unknown. Tachycardia was identified in the present case, but it was milder than that in dogs (Mesfin et al 1996;Hanton et al 2004;Jordan et al 2018). The tachycardia likely did not significantly affect the disease course in this cat.…”
Section: Discussioncontrasting
confidence: 58%
“…The cardiotoxicity of minoxidil is due to its haemodynamic effects rather than direct cardiotoxicity (Mesfin et al 1995). Canine experimental studies on minoxidil cardiotoxicity documented many changes in the pathological findings and echocardiographic parameters (Mesfin et al 1989;Hanton et al 2004). Various cardiac lesions due to MXT are related to vasodilation-induced ischemic injury and cardiac stimulation-induced myocardial hyperperfusion and hypoxia.…”
Minoxidil was originally introduced as a potent vasodilator, but is now widely used as a topical treatment for human alopecia. A 4-year-old neutered male Norwegian Forest cat presented with a 2-day history of anorexia, lethargy, and dyspnoea. A physical examination revealed hypothermia, tachypnoea, hypotension, and bilateral pulmonary crackles. The radiographs revealed pulmonary oedema and pleural effusions. The hypotension and pleural effusions exacerbated despite the supportive therapy, and the underlying cause remained undetermined. A further medical inquiry revealed the cat had been exposed to a topical minoxidil solution 3 days before admission. Accordingly, minoxidil toxicosis was managed using both i.v. fluids and vasopressors. Dopamine and norepinephrine were infused for 3 days to normalise the patient’s blood pressure and related clinical signs. The cat recovered fully and was discharged 6 days after the minoxidil exposure. This is the first report on the successful management of minoxidil toxicosis in a cat. To broaden our knowledge of minoxidil toxicosis in cats, we have also described the serial changes in the clinical findings of this cat over the treatment period. Furthermore, on the basis of the experience gained from this case, we suggest an optimised management plan for future cases of feline minoxidil toxicosis.
“…Moreover, ECG abnormalities in cats with MXT are unknown. Tachycardia was identified in the present case, but it was milder than that in dogs (Mesfin et al 1996;Hanton et al 2004;Jordan et al 2018). The tachycardia likely did not significantly affect the disease course in this cat.…”
Section: Discussioncontrasting
confidence: 58%
“…The cardiotoxicity of minoxidil is due to its haemodynamic effects rather than direct cardiotoxicity (Mesfin et al 1995). Canine experimental studies on minoxidil cardiotoxicity documented many changes in the pathological findings and echocardiographic parameters (Mesfin et al 1989;Hanton et al 2004). Various cardiac lesions due to MXT are related to vasodilation-induced ischemic injury and cardiac stimulation-induced myocardial hyperperfusion and hypoxia.…”
Minoxidil was originally introduced as a potent vasodilator, but is now widely used as a topical treatment for human alopecia. A 4-year-old neutered male Norwegian Forest cat presented with a 2-day history of anorexia, lethargy, and dyspnoea. A physical examination revealed hypothermia, tachypnoea, hypotension, and bilateral pulmonary crackles. The radiographs revealed pulmonary oedema and pleural effusions. The hypotension and pleural effusions exacerbated despite the supportive therapy, and the underlying cause remained undetermined. A further medical inquiry revealed the cat had been exposed to a topical minoxidil solution 3 days before admission. Accordingly, minoxidil toxicosis was managed using both i.v. fluids and vasopressors. Dopamine and norepinephrine were infused for 3 days to normalise the patient’s blood pressure and related clinical signs. The cat recovered fully and was discharged 6 days after the minoxidil exposure. This is the first report on the successful management of minoxidil toxicosis in a cat. To broaden our knowledge of minoxidil toxicosis in cats, we have also described the serial changes in the clinical findings of this cat over the treatment period. Furthermore, on the basis of the experience gained from this case, we suggest an optimised management plan for future cases of feline minoxidil toxicosis.
“…For the last 10 years, echocardiography has been increasingly used for toxicologic evaluation of drugs in laboratory animals. [24][25][26] TDI was introduced as a new noninvasive and sensitive method for quantitatively analyzing segmental myocardial function. 16,20 Myocardial velocities assessed by TDI reportedly are relatively independent of changes in ventricular loading conditions, 27 and several TDI variables, particularly MVG, better reflect myocardial function regardless of the presence of mitral regurgitation.…”
Background: Pimobendan (PIMO) is an inodilator that may have some beneficial effects in canine degenerative mitral valve disease (MVD). However, little information is available about its cardiac effects in dogs without systolic myocardial dysfunction.Hypothesis: Compared to benazepril (BNZ), an angiotensin-converting enzyme inhibitor, PIMO may worsen valve regurgitation in early canine MVD.Animals: Twelve Beagles with asymptomatic MVD were randomized into 2 groups (n 5 6) receiving BNZ or PIMO at dosages of 0.25 mg/kg PO q24h and q12h respectively, for 512 days.Methods: The study followed a blinded, randomized, prospective, and parallel group design. After day 512, the dogs were necropsied, and cardiac histopathology was performed in a blinded manner.Results: A significant treatment effect was observed as soon as day 15 with increased systolic function in the PIMO group by comparison to baseline value as assessed by fractional shortening (P , .0001) and tissue Doppler variables (P 5 .001). Concurrently, the maximum area and peak velocity of the regurgitant jet signal increased (P , .001), whereas these variables remained stable in the BNZ group. Histologic grades of mitral valve lesions were more severe in the PIMO group than in the BNZ group. Moreover, acute focal hemorrhages, endothelial papillary hyperplasia, and infiltration of chordae tendinae with glycosaminoglycans were observed in the mitral valves of dogs from the PIMO group but not in those of the BNZ group.Conclusions and Clinical Importance: PIMO has adverse cardiac functional and morphologic effects in dogs with asymptomatic MVD. Additional investigation in dogs with symptomatic MVD is now warranted.
“…[60][61][62][63][64] Unfortunately minoxidil has been demonstrated to be cardiotoxic in a number of common household pets. [65][66][67][68][69][70] At this stage minoxidil therapy should not be considered in animals.…”
Section: Treatment Modalitiescurrent and Emergingmentioning
Background
The hair follicle is a complete mini‐organ with a complex biology. Recent discoveries have shed light on the pathogenesis and genetic basis of a number of hair loss conditions, offering novel treatment alternatives.
Objective
To explore the biology and physiology of hair growth, the pathomechanism behind alopecias and emerging therapies.
Conclusion and clinical importance
Hair growth is influenced by numerous physiological moderators. Greater understanding of the biology and physiology of the hair follicle and the pathomechanisms of hair disease facilitates development of targeted treatments. Sublingual minoxidil is a promising therapy in humans where optimised drug delivery enhances efficacy and reduces systemic adverse effects. Janice kinase inhibitors, which disrupt the inflammatory cascade, help maintain the hair follicle, preserve immune privilege, and regrow hair in alopecia areata. As the pathomechanisms of other forms of alopecia become better understood, new targeted therapies with greater efficacy will emerge.
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