Use of Low Concentrations of Human IgA Anti-Tissue Transglutaminase to Rule Out Selective IgA Deficiency in Patients with Suspected Celiac Disease,

Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): A population control study

“…In a series of 51 patients with inflammatory myopathy, including 4 cases of IBM reported by Selva-O'Callaghan et al (2007), 2 of the IBM patients had coeliac disease and all 4 had antigliadin antibodies. Interestingly, all were negative for anti-transglutaminase antibodies which are generally regarded as having the highest sensitivity and specificity for the diagnosis of coeliac disease (Fernandez et al, 2005;Alaedini and Green, 2008). In another study of 99 patients with inflammatory myopathy, including 7 cases of IBM, anti-gliadin IgA levels were significantly elevated in inflammatory myopathy patients compared to controls and antitTg IgA levels were marginally increased (Orbach et al, 2009).…”

Celiac Disease and IgA Deficiency: Complications of Serological Testing Approaches Encountered in the Clinic

“…In our algorithm, all patients will be screened for IgA deficiency. This can be accomplished by measuring serum IgA in all patients, or by measuring serum IgA only in patients who have an IgA-tTG measurement below an absorbance cutoff concentration established to exclude IgA deficiency (24,38 ). An IgG-tTG will be automatically performed on patients with low or undetectable serum IgA concentration to test for celiac disease (6,12 ).…”

Celiac Disease: Are Endomysial Antibody Test Results Being Used Appropriately?

“…Alternatively, to reduce the number of serum IgA measurements, an IgA-tTG absorbance cutoff level can be established to effectively exclude IgA deficiency. Studies have demonstrated this process to be a cost-effective and practical protocol (39,40 ). IgAdeficient patients will have an IgG-tTG performed.…”