Use of Long-Acting Tetracyclines for Methicillin-Resistant Staphylococcus aureus Infections: Case Series and Review of the Literature

Ruhe, Jörg J.; Monson, Thomas P.; Bradsher, Robert W.; Menon, Anupama

doi:10.1086/429628

Cited by 139 publications

(63 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The expanded-spectrum tetracyclines doxycycline and minocycline demonstrate excellent oral bioavailability, tissue penetration, and tolerability (14). Published reports on the use of these agents for the treatment of MRSA SSTI suggest their effectiveness but are limited to case studies (2,3,23). Thus, more data are needed.…”

mentioning

confidence: 99%

Tetracyclines as an Oral Treatment Option for Patients with Community Onset Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus

Ruhe

Menon

2007

Antimicrob Agents Chemother

109

View full text Add to dashboard Cite

Few data exist on the clinical utility of the expanded-spectrum tetracyclines doxycycline and minocycline for the treatment of community-associated methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTI). We performed a retrospective cohort study of 276 patients who presented with 282 episodes of MRSA SSTI to the emergency room or outpatient clinic at two tertiary medical centers between October 2002 and February 2007. The median percentage of patients infected with MRSA strains that were susceptible to tetracycline was 95%. Time zero was defined as the time of the first incision and drainage procedure or, if none was performed, the time of the first positive wound culture. The median patient age was 48 years. Abscesses constituted the majority of clinical presentations (75%), followed by furuncles or carbuncles (13%) and cellulitis originating from a purulent focus of infection (12%). A total of 225 patients (80%) underwent incision and drainage. Doxycycline or minocycline was administered in 90 episodes (32%); the other 192 SSTI were treated with ␤-lactams. Treatment failure, defined as the need for a second incision and drainage procedure and/or admission to the hospital within at least 2 days after time zero, was diagnosed in 28 episodes (10%) at a median of 3 days after time zero. On logistic regression analysis, receipt of a ␤-lactam agent was the only clinical characteristic associated with treatment failure (adjusted odds ratio, 3.94; 95% confidence interval, 1.28 to 12.15; P ‫؍‬ 0.02). The expanded-spectrum tetracyclines appear to be a reasonable oral treatment option for patients with community onset MRSA SSTI in areas where MRSA strains are susceptible to the tetracyclines.

show abstract

mentioning

confidence: 99%

Tetracyclines as an Oral Treatment Option for Patients with Community Onset Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus

Ruhe

Menon

2007

Antimicrob Agents Chemother

109

View full text Add to dashboard Cite

show abstract

“…With this shift in the epidemiology of SSTI, empirical therapy for SSTI with ␤-lactams is often no longer thought to be acceptable in those clinical situations where antibiotic therapy is deemed to be necessary. While retrospective and observational data for the use of off-patent oral antimicrobials, such as tetracyclines, trimethoprim-sulfamethoxazole, and clindamycin, for treating MRSA SSTI have shown these agents to be effective, prospective randomized data for this therapy are largely unavailable (1,2,3,8,11).…”

mentioning

confidence: 99%

Prospective Randomized Trial of Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High Prevalence of Methicillin-Resistant Staphylococcus aureus

Cenizal

Skiest

Luber

et al. 2007

Antimicrob Agents Chemother

View full text Add to dashboard Cite

To evaluate empirical therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus, a randomized, prospective, open-label investigation was performed. The overall clinical failure rate was 9%, with all failures occurring in the trimethoprim-sulfamethoxazole group. However, there was no significant difference between the clinical failure rate of empirical trimethoprim-sulfamethoxazole therapy and that of doxycycline therapy.

show abstract

“…Gemmell et al, in their guidelines for prophylaxis and treatment of MRSA recommended use of tetracyclines for skin and soft tissue infections (Gemmell et al, 2006). Also both in vitro and clinical studies supported the use of doxycycline (Ruhe and Menon et al, 2007;Ruhe et al, 2005). Review literature on clinical use of cotrimoxazole by Goldberg and Bishara recommended this drug for treatment of MRSA in skin and soft tissue infections (Goldberg and Bishara et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Study of Antibiotic Susceptibility Pattern in Staphylococcus aureus Isolated from Skin and Soft Tissue Infections in a Tertiary Care Hospital

Dhope¹,

Ghadage²,

Bhore³

2017

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Use of Long-Acting Tetracyclines for Methicillin-Resistant Staphylococcus aureus Infections: Case Series and Review of the Literature

Abstract: Long-acting tetracyclines may be a reasonable treatment alternative for patients with certain types of MRSA infection.

Cited by 139 publications

References 23 publications

Tetracyclines as an Oral Treatment Option for Patients with Community Onset Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus

Tetracyclines as an Oral Treatment Option for Patients with Community Onset Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus

Prospective Randomized Trial of Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High Prevalence of Methicillin-Resistant Staphylococcus aureus

Study of Antibiotic Susceptibility Pattern in Staphylococcus aureus Isolated from Skin and Soft Tissue Infections in a Tertiary Care Hospital

Contact Info

Product

Resources

About