The advancement of domestic research and development work on reactor technologies from the world's first NPP built in Obninsk to modern fast reactors with liquid-metal coolants is analyzed. The contribution of the Institute for Physics and Power Engineering to the development of a strategy for the advancement of large-scale nuclear power based on a closed nuclear fuel cycle with fast reactors is examined. It is noted that a scientific and technical base now exists for implementing our country's initiative for securing sufficient energy for stable development of the world and the global infrastructure for nuclear power based on a network of international nuclear fuel centers and expanded exports of new-generation nuclear power plants with thermal and fast reactors including an attractive package of NFC services. The basic problems are formulated within the framework of the future development of reactor technologies for improving the safety and cost-effectiveness of NPPs with new-generation fast reactors which are now in operation or being designed.The successful startup on June 27, 1954 in Obninsk of the world's first NPP became the most important landmark in the development of world nuclear power and a reference point of the transition to peaceful uses of atomic energy [1,2].More than 120 designs of different nuclear power plants were developed under the scientific supervision of the Leipunskii Institute for Physics and Power Engineering (FEI). Among them were the world's first fast power reactor BN-350, the fast reactor BN-600 operating in the Urals power system, the pulsed fast reactor IBR (Dubna), a series of nuclear submarines with nuclear power setups cooled by molten lead-bismuth (designs 645, 705) and the converter reactors BUK and TOPAZ for use in space. This enabled our country to take a leading position in fast-reactor technology in the world.The work performed at the FEI is now focused on scientific research for validating the development of nuclear reactors cooled by liquid metals. In addition, the FEI holds an important position in development work associated with water cooled and moderated reactors. The Institute performs research in nuclear physics, the physics of nuclear reactors, thermal physics and hydraulics, corrosion of structural materials, radiation materials science, technology of liquid-metal coolants, chemistry and radiochemistry as well as other fields of nuclear science and engineering. To perform such research, the FEI employs highly trained cadres and modern experimental resources. The Institute works in cooperation with many institutes, design organizations, and nuclear industry organizations.NPP with Channel, Water-Graphite, and Water Moderated and Cooled Reactors Development and startup of the first NPP. By the time that the work on the world's first NPP was transferred to Laboratory V, which subsequently became the FEI, only the overall design features of the AM reactor were determined. Many physical, technical, and technological problems remained to be solved. First and foremost...