Use of lidocaine in endotracheal intubation. Blood and urine concentrations in patients and deceased after unsuccessful resuscitation

Determination of Lidocaine in Postmortem Whole Blood Samples after Unsuccessful Cardiopulmonary Resuscitation

“…Previously, Wunder et al [11] have reported that the lidocaine concentration in postmortem cardiac whole blood samples, where antemortem CPR had been performed, ranged between 0.07-1.07 µg/mL and that these levels were at the same order of magnitude as determined in antemortem samples after one hour of controlled exposure. Our results were in accordance with the previously described studies as the concentrations were found to be in the range of 0.21-0.96 µg/mL.…”

“…An Agilent J&W HP-5MS fused-silica capillary column (30 x 0.25 mm i.d., 0.25 film thickness) was used for GC separation. GC oven temperature program was the following; initial temperature: 120 °C for 1 min, final temperature: 300 °C with a rate of 15 °C/min, total run Previous studies have shown that postmortem lidocaine concentrations, after unsuccessful CPR, in whole blood and urine lie between the subtherapeutic and therapeutic range [11]. In literature, there are analytical methods for the determination of lidocaine in blood, urine and tissues with GC/MS, most of these studies all have one common feature, they require evaporation and the majority of them use big amounts of organic solvent.…”

“…As stated by Benowitz et al [10]: "Pharmacokinetic studies in man show wide variability in drug disposition between patients, even when cardiac and hepatic status is considered, making specific dosing recommendations a problem", thus the development of a method for the determination of lidocaine in the biological fluids of the deceased is crucial for the accurate interpretation of the toxicological results. Previous studies have shown that postmortem lidocaine concentrations, after unsuccessful CPR, in whole blood and urine lie between the subtherapeutic and therapeutic range [11]. In literature, there are analytical methods for the determination of lidocaine in blood, urine and tissues with GC/MS, most of these studies all have one common feature, they require evaporation and the majority of them use big amounts of organic solvent.…”