Use of Letrozole versus clomiphene-estradiol for treating infertile women with unexplained infertility not responding well to clomiphene alone, comparative study

Harira, Mervat

doi:10.1016/j.mefs.2018.05.008

Cited by 10 publications

(13 citation statements)

References 25 publications

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“…With Clomiphene citrate, the biochemical pregnancy was found to be 28.8% with live birth rate 18% as shown in Figure 5. 26 [30][31][32][33] b. In patients with unexplained infertility ( Figure 6.…”

Section: Efficacy Of Letrozole In Overcoming Infertility In Various Pmentioning

confidence: 99%

Letrozole: an emerging array of hope for infertile women

Maladkar¹,

Tekchandani²,

Karchodi³

2020

Int J Reprod Contracept Obstet Gynecol

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Ovulation induction has been a major breakthrough in the management of female infertility since many decades. Letrozole, an aromatase inhibitor has been used as a potential therapy for ovulation induction. A large number of clinical evidences have been emerging which cite the beneficial role of Letrozole in conditions like anovulatory infertility, polycystic ovary syndrome (PCOS), unexplained infertility and an incipient role in endometriosis- related infertility with regards to higher live-birth rates. Letrozole is a superior alternative to Clomiphene citrate (CC) which has been used conventionally as ovulation inducer. Clomiphene citrate has certain well-defined disadvantages, whereas Letrozole overcomes these limitations to a reasonable extent. The peripheral anti-estrogenic effect of CC leads to prolonged depletion of estrogens receptors, adversely affecting endometrial growth and development as well as quantity and quality of cervical mucus. Persistent blockade of estrogen receptor leads to CC resistance and is associated with reduced ovulation and pregnancy rates. Available evidences suggest Letrozole is superior to CC owing to the lack of persistent anti-estrogenic action due to its short half- life and lack of action on estrogen receptors. This typically leads to monofollicular growth and also higher live birth rates. The current evidences suggest that Letrozole can be placed as first line therapy for the management of infertility due to PCOS and unexplained infertility.

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Section: Efficacy Of Letrozole In Overcoming Infertility In Various Pmentioning

confidence: 99%

Letrozole: an emerging array of hope for infertile women

Maladkar¹,

Tekchandani²,

Karchodi³

2020

Int J Reprod Contracept Obstet Gynecol

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“…The success rate of the IUI/COH method reported was about 11-16.4%. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Several factors that in uence the success rates of IUI/COH, including: (1) type of stimulation, such as the use of Clomiphene citrate (CC) and Letrozole; (2) timing of ovulation after trigger shot was administered as determined by measurement of the dominant follicle (follicle size); and (3) endometrial thickness. [20][21][22][23][24][25][26] IUI is performed using a variety of ovarian stimulators such as CC and Letrozole.…”

Section: Introductionmentioning

confidence: 99%

“…According to previous studies, Letrozole was superior to CC. [20][21][22][23][24][25][26] The size of the follicle is also a factor considered to become as predictive factors of the IUI success rate. Multiple studies have demonstrated that the ideal follicle size to improve the likelihood of pregnancy is 18-22 mm.…”

Section: Introductionmentioning

confidence: 99%

“…[26][27][28] Thus, the data concerning the e cacy of ovarian stimulation and its relationship to follicle size as well as the endometrial thickness, are still inconsistent and unclear. [20][21][22][23][24][25][26][27][28][29] In addition, there are currently no data correlating the type of ovarian stimulation, follicle size, and endometrial thickness simultaneously to pregnancy rates in fertility clinics in Indonesia, particularly in Bandung, such as the Aster Clinic, Dr. Hasan Sadikin General Hospital Bandung and Bandung Fertility Center. This study was performed to observe the relationship between follicle size, endometrial thickness, and types of ovarian stimulation (Clomiphene citrate/ CC vs Letrozole) with pregnancy rate especially biochemical pregnancy rate in IUI.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Several factors that in uence the success rates of IUI/COH, including: (1) type of stimulation, such as the use of Clomiphene citrate (CC) and Letrozole; (2) timing of ovulation after trigger shot was administered as determined by measurement of the dominant follicle (follicle size); and (3) endometrial thickness. [20][21][22][23][24][25][26] IUI is performed using a variety of ovarian stimulators such as CC and Letrozole. CC and Letrozole have become the drug of choice since CC is the rst-line regimen, Letrozole is one of the rst-line regimens for inducing ovulation in IU cases, and they are both inexpensive.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Follicle Size, Endometrial Thickness, and Types of Ovarian Stimulation (Clomiphene Citrate and Letrozole) With Biochemical Pregnancy Rate in Women Undergone Intrauterine Insemination

Rachmawati

Krisnadi

Santoso

et al. 2023

Preprint

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Objective: There was also a lack of data regarding the effect of follicle size, endometrial thickness, and ovarian stimulation as predictors of intrauterine insemination (IUI) success rate in Indonesia, especially in the Aster Clinic and Bandung Fertility Centre. This study was performed to explore the relationship between follicle size, endometrial thickness, and types of ovarian stimulation (Clomiphene citrate/CC vs Letrozole) with biochemical pregnancy rate in women undergone IUI. We performed a case-control study in 122 women aged 20-40 years with unexplained infertility who had completed the IUI program for a maximum of three cycles. Data were extracted from medical records. Independent T-test and multivariate analyses were used to analyse the difference between variables using IBM SPSS 24.0. P-value < 0.05 was considered statistically significant. Result: Follicle sizes of 18-22 mm in both Clomiphene citrate (CC) and Letrozole groups were shown to increase biochemical pregnancy rate (P= 0.001). There is no relationship between endometrial thickness and pregnancy rate. Biochemical pregnancy rate in women using Letrozole was 1.513 times higher than women using CC. The follicle size of 18-22 mm and using Letrozole rather than CC as ovarian stimulators are predictive factors associated with a higher pregnancy rate in women undergone IUI.

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