Use of LC-MS/MS for xenobiotic metabolism studies in animals

Debrauwer, Laurent

doi:10.1051/analusis:2000280914

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Accordingly, it was difficult to obtain a pure sample. Metabolite A had a low R f value (0.04) and exhibited the following mass spectrum [m/z (relative intensity, (Debrauwer, 2000;Ishikawa et al, 2004;Cai et al, 2002). In this way, metabolite A was identified as N-methylmyosmine, and the structure is shown as II in Fig.…”

Section: Isolation and Identification Of Metabolite A By Tlc And Gc-hmentioning

confidence: 99%

Characterization of environmentally friendly nicotine degradation by Pseudomonas putida biotype A strain S16

et al. 2007

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Nicotine and some related alkaloids in tobacco and tobacco wastes are harmful to health and the environment, and a major environmental requirement is to remove them from tobacco and tobacco wastes. In this study, an isolated strain, S16, identified as Pseudomonas putida biotype A, was used to investigate nicotine degradation. Possible intermediates were identified based on the results of NMR, Fourier-transform (FT)-IR and UV spectroscopy, GC-MS and high-resolution MS (HR-MS) analysis. The pathway of nicotine degradation in P. putida was proposed to be from nicotine to 2,5-dihydroxypyridine through the intermediates N-methylmyosmine, 29-hydroxynicotine, pseudooxynicotine, 3-pyridinebutanal,C-oxo, 3-succinoylpyridine and 6-hydroxy-3-succinoylpyridine. N-Methylmyosmine, 2,5-dihydroxypyridine and succinic acid were detected and satisfactorily verified for the first time as intermediates of nicotine degradation. In addition, an alcohol compound, 1-butanone,4-hydroxy-1-(3-pyridinyl), was found to be a novel product of nicotine degradation. These findings provide new insights into the microbial metabolism of nicotine and the environmentally friendly route of nicotine degradation.

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Section: Isolation and Identification Of Metabolite A By Tlc And Gc-hmentioning

confidence: 99%

Characterization of environmentally friendly nicotine degradation by Pseudomonas putida biotype A strain S16

et al. 2007

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“…[17] Recent studies on the elucidation of fragmentation pathways have addressed topics such as forensic toxicology, doping control and environmental analysis. [18] The literature to meet similar needs for veterinary drug analysis is incomplete, only covering some sulfonamides, [19][20][21][22][23][24] and a few β-agonists, [25,26] fluoroquinolones, [27,28] macrolides, [29] and cephalosporins. [30,31] The aim of this study was to characterize 186 previously selected precursor ion-product ion transitions of 62 priority veterinary drugs monitored with UHPLC coupled to a triple quadrupole mass spectrometer (UHPLC/MS/MS) operated in positive electrospray ionization (ESI) mode.…”

mentioning

confidence: 99%

“…Recent studies on the elucidation of fragmentation pathways have addressed topics such as forensic toxicology, doping control and environmental analysis . The literature to meet similar needs for veterinary drug analysis is incomplete, only covering some sulfonamides, and a few β‐agonists, fluoroquinolones, macrolides, and cephalosporins …”

mentioning

confidence: 99%

Structural characterization of product ions by electrospray ionization and quadrupole time-of-flight mass spectrometry to support regulatory analysis of veterinary drug residues in foods

Geis-Asteggiante

Núñez

Lehotay

2014

Rapid Commun. Mass Spectrom.

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Current Awareness

2001

J. Mass Spectrom.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of mass spectrometry. Each bibliography is divided into 11 sections: 1 Books, Reviews & Symposia; 2 Instrumental Techniques & Methods; 3 Gas Phase Ion Chemistry; 4 Biology/Biochemistry: Amino Acids, Peptides & Proteins; Carbohydrates; Lipids; Nucleic Acids; 5 Pharmacology/Toxicology; 6 Natural Products; 7 Analysis of Organic Compounds; 8 Analysis of Inorganics/Organometallics; 9 Surface Analysis; 10 Environmental Analysis; 11 Elemental Analysis. Within each section, articles are listed in alphabetical order with respect to author (4 Weeks journals ‐ Search completed at 13th. June. 2001)

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Use of LC-MS/MS for xenobiotic metabolism studies in animals

Cited by 7 publications

References 34 publications

Characterization of environmentally friendly nicotine degradation by Pseudomonas putida biotype A strain S16

Characterization of environmentally friendly nicotine degradation by Pseudomonas putida biotype A strain S16

Structural characterization of product ions by electrospray ionization and quadrupole time-of-flight mass spectrometry to support regulatory analysis of veterinary drug residues in foods

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