Use of labetalol and glyceryl trinitrate for induced hypotension in spine surgery- A comparative study

Yeasmeen, Sabina; Siddique, Rafayet Ullah; Islam, Anwarul; Aktaruzzaman, Akm; Banik, Debabrata; Hye, Abdul

doi:10.3329/jbsa.v22i2.18141

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…One group received TNG, 1000 microgram, and the other group received labetalol, 5 mg, intravenously. They found a significantly higher score for surgical field quality and less bleeding in labetalol group ( 15 ). It is also interesting that they achieved these results with a much lower dose of labetalol as 5 mg.…”

Section: Discussionmentioning

confidence: 93%

Comparing Labetalol and Nitroglycerine on Inducing Controlled Hypotension and Intraoperative Blood Loss in Rhinoplasty: A Single-Blinded Clinical Trial

et al. 2017

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BackgroundUncontrolled bleeding during surgery is one of the main predisposing factors for failure of the surgeon and complications following rhinoplasty. The current study aimed at comparing the effects of nitroglycerine and labetalol on the induction of controlled hypotension and bleeding volume during septorhinoplasty.MethodsThe current randomized, controlled, clinical trial enrolled 60 patients candidate for septorhinoplasty at Firoozgar hospital in Tehran, Iran, in 2 equal groups receiving either 0.1 to 1 mcg/kg/minute nitroglycerine or 2 to 4 mg/minute labetalol to achieve a mean arterial blood pressure of about 60 to 65 mmHg. In case the targeted blood pressure was not achieved, isoflurane was added. Degree of bleeding was evaluated by the volume of suctioned blood and the blood remaining in surgical gauzes. Additionally, the surgeon's satisfaction with the surgical field was evaluated by a scoring system. The collected data were, then, compared between the study groups by the statistical methods.ResultsBased on the current study findings, systolic (P < 0.001), diastolic (P = 0.002), and the mean arterial blood pressures (P < 0.001) were significantly lower in the nitroglycerine group. Ninety percent of the patients in the labetalol group received isoflurane to achieve the targeted blood pressure defined as controlled hypotension. There was no significant difference between the groups regarding the volume of bleeding (P = 0.75); however, the surgeons were more satisfied with nitroglycerine than labetalol (P < 0.001).ConclusionsIt was concluded that nitroglycerine had a better effect, in comparison to labetalol, on inducing the controlled hypotension in septorhinoplasty.

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Section: Discussionmentioning

confidence: 93%

Comparing Labetalol and Nitroglycerine on Inducing Controlled Hypotension and Intraoperative Blood Loss in Rhinoplasty: A Single-Blinded Clinical Trial

et al. 2017

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“…Presynaptic alpha-2 receptors are spared by labetalol so that the released norepinephrine can continue to inhibit further release of catecholamines via the negative feedback mechanism resulting from the stimulation of alpha-1 receptors. Moreover this drug targets 5-10 times more specific beta blockade 11,23 and prevent rebound hypertension and tachycardia. 20,10 Researchers used Labetalol and nitroprusside to induce hypotension in major surgeries and showed that nitroprusside significantly increased the heart rate but cardiac output remain unchanged with labetalol administration.…”

Section: Discussionmentioning

confidence: 99%

Comparison of effect of Labetalol and fentanyl with only fentanyl for attenuating pressure responses to intubation and skull pin insertion in neurosurgery

2020

IJCA

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Comparing the hemodynamic changes, bleeding, and surgeon’s satisfaction during rhinoplasty surgery by use of two drugs, labetalol and dexmedetomidine added to anesthetic technique: a randomized clinical trial

Radman,

Mousavi,

Jadidi

et al. 2024

Il Giornale Di Chirurgia - Journal of the Italian Association of Hospital Surgeons

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Background: Rhinoplasty is a common surgery in the world. Bleeding is a common concern during rhinoplasty. Hemodynamic stability and quality of view of the surgical field help to achieve the best results. The aim was to compare the effect of two drugs, dexmedetomidine and labetalol, on the amount of bleeding and satisfaction with rhinoplasty surgery. Methods: A cross-sectional descriptive study includes candidates for rhinoplasty surgery, referring to Moradi Hospital in Rafsanjan. Twenty patients were assigned to each group (dexmedetomidine and labetalol) based on the entry and exit criteria. Systolic and diastolic blood pressures and mean arterial pressure were measured before, 20 minutes after complete anesthesia, and the start of rhinoplasty surgery. All patients were operated by the same surgeon using the same technique. The surgeon’s level of satisfaction indicated with the field of vision is given as follows: good, moderate, and poor. Results: The study was performed on 40 subjects in two groups (n = 20), of which 14 (35 %) were male and 26 (65 %) were female. The results presented statistically significant differences in mean osteotomy systolic blood pressure (P = 0.018), osteotomy diastolic blood pressure (P = 0.015), mean osteotomy arterial pressure (P = 0.002), after 20 minutes heart rate (P < 0.001), and osteotomy heart rate (P = 0.001) between two groups. Furthermore, significant differences were observed regarding systolic blood pressure (P = 0.015), mean arterial pressure (P = 0.03), and heart rate (P < 0.001) after controlling for the effect of the group. Conclusions: The labetalol is the preferred option for controlling hypotension that provides better surgical field visibility compared to dexmedetomidine in rhinoplasty surgery.

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Use of labetalol and glyceryl trinitrate for induced hypotension in spine surgery- A comparative study

Cited by 4 publications

References 14 publications

Comparing Labetalol and Nitroglycerine on Inducing Controlled Hypotension and Intraoperative Blood Loss in Rhinoplasty: A Single-Blinded Clinical Trial

Comparing Labetalol and Nitroglycerine on Inducing Controlled Hypotension and Intraoperative Blood Loss in Rhinoplasty: A Single-Blinded Clinical Trial

Comparison of effect of Labetalol and fentanyl with only fentanyl for attenuating pressure responses to intubation and skull pin insertion in neurosurgery

Comparing the hemodynamic changes, bleeding, and surgeon’s satisfaction during rhinoplasty surgery by use of two drugs, labetalol and dexmedetomidine added to anesthetic technique: a randomized clinical trial

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