Use of intraoperative cytologic assessment of mandibular marrow scrapings to predict resection margin status in patients with squamous cell carcinoma

Mahmood, Shaukat; Conway, David; Ramesar, K.

doi:10.1053/joms.2001.26710

Cited by 22 publications

(19 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mahmood et al 27 chose a further approach to circumvent frozen sections by intraoperative cytological assessment of bone marrow specimens, obtained from mandibular bone resection margins. 27 Despite the limited number of 35 cancellous bone smear=touch preparations from 7 patients, the study provided insight into the feasibility of the cytological assessment of bone margins. All cytological findings correlated with the final histological results and the procedure proved to be easy, cost-effective, and reliable for routine clinical use.…”

Section: Discussionmentioning

confidence: 99%

“…The need for a definitive intraoperative evaluation of bone margins is obvious . Promising approaches have been presented to address this demand, including cytology . However, to our knowledge to date none of the approaches has obtained general acceptance, mostly due to the lack of practicability and reliability (Table 1) …”

Section: Introductionmentioning

confidence: 99%

“…8 Promising approaches have been presented to address this demand, including cytology. [21][22][23][24][25][26][27] However, to our knowledge to date none of the approaches has obtained general acceptance, mostly due to the lack of practicability and reliability (Table 1). [21][22][23][24][25][26][27][28] The objective of the current study was to introduce the intraoperative cytological assessment of the bone resection margins (ICAB) in patients with OSCC and evaluate its practicability and diagnostic value for routine clinical use.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of intraoperative cytological assessment of bone resection margins in patients with oral squamous cell carcinoma

Nieberler

Häusler

Drecoll

et al. 2014

Cancer Cytopathology

View full text Add to dashboard Cite

BACKGROUND:Frozen sections are routinely applied to control for adequate resection margins. In cases in which carcinoma infiltrates bone, the intraoperative microscopic assessment of bone margins remains challenging due to technical difficulties to section native bone. The objective of the current study was to evaluate an intraoperative cytological approach to control bone resection margins in patients with bone-infiltrating oral squamous cell carcinomas. METHODS:A total of 174 cytological preparations obtained from bone margins of bone-infiltrating oral squamous cell carcinomas (28 patients) were assessed intraoperatively and compared with the corresponding histological findings. In a validation cohort (45 patients) the intraoperative cytological assessment of bone resection margins (ICAB) (104 margins) was evaluated as a diagnostic tool for routine clinical application. RESULTS: In the first patient cohort, the ICAB revealed 95.3% sensitivity and 96% specificity. The results provided an accuracy of 95.7% with a significant correlation noted between cytological and histological results (j, 0.91; P <.001), and a positive predictive value and negative predictive value of 93.8% and 96.9%, respectively. In the validation cohort, ICAB revealed 80% sensitivity and 98.9% specificity with 98% accuracy. There was a significant correlation found between cytological and histological results (j, 0.91; P <.001), providing a positive predictive value and negative predictive value of 80% and 98%, respectively. ICAB could predict final resection status at bone margins with 80% sensitivity and 97.5% specificity. A significant correlation was found between the cytological and histological resection status at bone margins (j, 0,75; P <.001). CONCLUSIONS: ICAB could supplement intraoperative frozen sections of soft tissue margins as a standard procedure to control for adequate resection at bone margins. Cancer (Cancer Cytopathol) 2014;122:646-56.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of intraoperative cytological assessment of bone resection margins in patients with oral squamous cell carcinoma

Nieberler

Häusler

Drecoll

et al. 2014

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

“…Die Zuverlässigkeit der zytologischen Untersuchung bei der Beurteilung von Sicherheitsabständen nach Tumorexstirpationen wurde in der vorliegenden Arbeit nicht systematisch überprüft. Die Bedeutung wird in der Humanmedizin kontrovers diskutiert (8,14), da aufgrund der mangelhaften Einschätzung der Gewebearchitektur eine sensitive Erfassung einer Tumorzellausbreitung in gesundes Nachbargewebe fragwürdig erscheint.…”

Section: Diskussionunclassified

Zur intraoperativen zytologischen Diagnostik bei Hund und Katze

Stockhaus¹,

Taprogge²,

Schoon³

et al. 2004

Tierarztl Prax Ausg K

View full text Add to dashboard Cite

Zusammenfassung: Gegenstand und Ziel: Überprüfung der diagnostischen Aussagekraft der intraoperativen zytologischen Schnelldiagnostik bei Hunden und Katzen in einer prospektiven Untersuchung (2/2001-5/2002). Material und Methoden: Das Patientengut umfasste 129 Hunde und 19 Katzen, bei denen intraoperativ zytologische Abklatschbioptate unterschiedlicher Lokalisationen gewonnen wurden. Es handelte sich um Proben der folgenden Areale: Haut/Unterhaut (n = 55), Bewegungsapparat/Wirbelsäule (n = 29), Gekröse/Gekröselymphknoten/Peritoneum/Abdomen (n = 16), Urogenitaltrakt (n = 14), Gastrointestinaltrakt (n = 14), Leber (n = 12), Maulhöhle (n = 12), Milz (n = 7), endokrine Organe (n = 5) und Respirationstrakt (n = 4). Bei allen Exzisionsbioptaten erfolgte eine zytologische und eine histopathologische Untersuchung. Ergebnisse: Bei der histologischen Untersuchung wurden 98 Neoplasien sowie 70 nichtneoplastische Veränderungen festgestellt. Bei 13 zytologischen Proben (7,7%) war das Präparat aufgrund einer zu geringen Zellularität nicht beurteilbar. Bei der zytologischen Beurteilung der Dignität ergaben sich eine Sensitivität von 88% (95%-Konfidenzintervall [95%-KI]: 78,4-94,4%), eine Spezifität von 91,3% (95%-KI: 81,9-96,7%) und eine diagnostische Sicherheit von 89,6% (95%-KI: 84,6-94,6%). Wurde als Kriterium zur Überprüfung der Zytologie neben der Dignität zusätzlich die Histogenese (epitheliale/mesenchymale Neoplasie) berücksichtigt, lagen die Werte niedriger: Sensitivität 78,7% (95%-KI: 68,2-87,1%), Spezifität 90,6% (95%-KI: 80,7-96,4%), diagnostische Sicherheit 84% (95%-KI: 78,0-90,0%). Von den auswertbaren Präparaten ließen sich bei den verschiedenen Organregionen mit den folgenden Häufigkeiten korrekte Aussagen zur Dignität treffen: Haut/Unterhaut (43/45), Bewegungsapparat/Wirbelsäule (22/23), Gekröse/Gekröselymphknoten/Peritoneum/Abdomen (10/14), Urogenitaltrakt (12/13), Gastrointestinaltrakt (11/12), Leber (11/11), Maulhöhle (9/11), Milz (3/6), endokrine Organe (5/5) und Respirationstrakt (3/4). Schlussfolgerung und klinische Relevanz: Bei ausreichender Erfahrung des Untersuchers liefert die intraoperative Abklatschzytologie wertvolle Hinweise hinsichtlich der Dignität und Ausbreitung von Erkrankungen und kann somit eine wesentliche Entscheidungshilfe darstellen. Sie sollte immer mit einer postoperativen histologischen Untersuchung von Gewebebioptaten kombiniert werden.

show abstract

“…Imaging modalities, including computer tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and single‐positron emission computed tomography (SPECT), are useful in the process of preoperative planning, but are also limited by inconsistent sensitivity, inability to reliably predict the precise extent of invasion, and artifact (e.g., metallic dental prostheses on CT scans) . The infiltrative histologic subtype of squamous cell carcinoma (SCCa) affects the medullary space in ∼90% of cases, and the extent of cancellous bone involvement is inadequately assessed by traditional imaging techniques . The cited efficacy of MRI in detecting cancellous bone involvement varies depending on the study .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion

Namin

Bruggers²,

Panuganti

et al. 2014

The Laryngoscope

View full text Add to dashboard Cite

show abstract

Use of intraoperative cytologic assessment of mandibular marrow scrapings to predict resection margin status in patients with squamous cell carcinoma

Cited by 22 publications

References 8 publications

Evaluation of intraoperative cytological assessment of bone resection margins in patients with oral squamous cell carcinoma

Evaluation of intraoperative cytological assessment of bone resection margins in patients with oral squamous cell carcinoma

Zur intraoperativen zytologischen Diagnostik bei Hund und Katze

Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion

Contact Info

Product

Resources

About