Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour

Gopinath, Divya; Draffan, D.; Philbey, Adrian; Bell, R.

doi:10.1111/j.1748-5827.2008.00671.x

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…1,49 However, metastatic spread of SCT has manifested up to 4 years after removal of the primary tumor. 50 For cases with metastatic disease, the prognosis should be considered poor. 48,[51][52][53][54] For these reasons, and in light of significant concentrations of serum AMH concentrations remaining 3 weeks after surgical removal of the neoplastic testis, an appointment for tumor surveillance 3 months after surgery was recommended.…”

Section: Estrone Sulphatementioning

confidence: 99%

Canine Sertoli cell tumor: anti-Müllerian hormone, inhibin B, and estrone sulphate

Herzog¹,

Adams²,

Blanc³

et al. 2023

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A unilaterally castrated male boxer was referred for chronic generalized alopecia and pruritus. Physical examination revealed symmetrical alopecia, pendulous prepuce, lichenification of the scrotum, and enlargement of mammary papillae. Penile/preputial cytology revealed superficial epithelial cells. Transabdominal ultrasonographic examination revealed a globoid mass with heterogenous echogenicity in the left caudal abdomen. The presumptive diagnosis was Sertoli cell tumor (SCT) associated with cryptorchidism. Exploratory laparotomy and histology of the removed mass confirmed the diagnosis. Three weeks after surgery, serum anti-Müllerian hormone (AMH) concentrations decreased from 8,435 to 56 ng/ml and inhibin B decreased from 805 to < 6 pg/ml. Two months after surgery dermatoses subsided and there was substantial regression of enlarged nipples. This report highlights the diagnostic value of practical procedures (penile/preputial cytology, transabdominal ultrasonography, and measurement of serum AMH and inhibin B concentrations) to aid in the diagnosis of cryptorchidism and SCT, especially in patients with generalized skin conditions.

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Section: Estrone Sulphatementioning

confidence: 99%

Canine Sertoli cell tumor: anti-Müllerian hormone, inhibin B, and estrone sulphate

Herzog¹,

Adams²,

Blanc³

et al. 2023

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“…A pathogenic association between oestrogen production and development of TTs has been observed (Walker 1968 ). One in five dogs with SCTs displays signs of feminisation syndrome (FS) resulting from hyperoestrogenism (Gopinath et al 2009 ). The association of FS with TTs was prompted by the observation that signs of feminisation in male dogs disappear when the tumour is removed and reoccur when functional metastases are present (Gopinath et al 2009 ).…”

Section: Mammary Gland Tumours In Male Dogsmentioning

confidence: 99%

“…One in five dogs with SCTs displays signs of feminisation syndrome (FS) resulting from hyperoestrogenism (Gopinath et al 2009 ). The association of FS with TTs was prompted by the observation that signs of feminisation in male dogs disappear when the tumour is removed and reoccur when functional metastases are present (Gopinath et al 2009 ). The signs of feminisation include alopecia, attractiveness to other male dogs, pendulous prepuce, and mammary gland abnormalities, e.g.…”

Section: Mammary Gland Tumours In Male Dogsmentioning

confidence: 99%

Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review

Tkaczyk-Wlizło,

Kowal,

Śmiech

et al. 2023

J Appl Genetics

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Mammary gland tumours (MGTs) are commonly occurring neoplasms in female dogs. However, rare cases of MGTs in male dogs have been reported for years. Due to the low incidence of MGTs in male dogs in comparison to female dogs, veterinary oncology is mainly focused on mammary neoplasms diagnosed in female dogs and extensive research is conducted in this scientific area. Therefore, there are no sufficient epidemiological data on male dogs and the aetiology of their tumour development is still poorly understood.The aim of this literature review was to present cases of MGTs in male dogs for better understanding the scale of the problem over the years. The analyses of 74 affected male dogs with 92 tumours showed that the majority of MGTs in male dogs were benign tumours (54.3%), especially in form of adenomas, often developed in posterior canine mammary glands (58.1%).The increased number of canine MGTs in male dogs aged 7 -13 years with an age peak at 11 years was noted. The age of affected animals was not related to breed. Mammary gland neoplasms were diagnosed predominately in Crossbreeds (20.2%) followed by Cocker Spaniels (18.9%) and German Shepherds (10.8%).The association between MGT development in male dogs and co-occurrence of testicular tumours (TTs) has been discussed for years. Thus, cases of development of both tumours were included in this study. As a result, only in 12.7% cases of MGTs also history of TTs was described. Therefore, no general association between these tumours should be assumed.

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“…These signs are observed mainly in dogs with Sertoli-cell tumours and occasionally also with Leydig cell tumours or seminoma [ 9 , 12 , 13 ]. Testicular tumours are rarely malignant, but when metastases occur they are most commonly found in the iliac lymph nodes and lungs [ 2 , 14 ]. Bone marrow hypoplasia is a life-threatening condition associated with oestrogen production of tumours, most often SCT, and dogs may develop clinical signs related to bone marrow hypoplasia before the owner has noted other clinical signs related to oestrogen production [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian hormone: a potentially useful biomarker for the diagnosis of canine Sertoli cell tumours

Holst

Dreimanis

2015

BMC Vet Res

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BackgroundTesticular tumours are common in dogs and in many cases do not give rise to clinical signs. In other cases, signs of feminization, hyperpigmentation or alopecia may be observed, most commonly associated with Sertoli cell tumours (SCT). Although these signs are often associated with elevated concentrations of oestradiol, analysis of oestradiol may give inconclusive results due to large variations among individuals. Other biomarkers are therefore needed. Anti-Müllerian hormone (AMH) is expressed by the Sertoli cell. In humans, AMH has been shown to be a specific marker of Sertoli cell origin in gonadal tumours. Using immunohistochemistry, AMH has been shown to be a useful marker of immature and neoplastic Sertoli cells in dogs. The aim of the present study was to evaluate the clinical relevance of AMH analysis in peripheral blood in the diagnostic workup of dogs with suspected testicular tumours.ResultsBlood was collected from 20 dogs with a palpable testicular mass and from 27 healthy controls. Serum was analysed for oestradiol-17β using a RIA and for AMH using an ELISA. The Mann–Whitney U test was used to compare hormone concentrations between different groups.All control dogs had AMH concentrations ≤ 10 ng/mL, except one outlier that had a concentration of 43 ng/mL. Six dogs with SCT or mixed tumours containing SCT had AMH concentrations higher than 22 ng/mL, significantly higher than AMH concentrations in control dogs (P = 0.0004). Concentrations between 10 and 22 ng/mL were found in about half of the dogs with non-neoplastic testicular pathologies or with testicular tumours other than SCTs. Age did not significantly affect concentrations of AMH in the control dogs.ConclusionAMH was shown to be a promising biomarker for the diagnosis of Sertoli cell tumours in dogs.

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Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour

Cited by 10 publications

References 8 publications

Canine Sertoli cell tumor: anti-Müllerian hormone, inhibin B, and estrone sulphate

Canine Sertoli cell tumor: anti-Müllerian hormone, inhibin B, and estrone sulphate

Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review

Anti-Müllerian hormone: a potentially useful biomarker for the diagnosis of canine Sertoli cell tumours

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