Use of intensified early cancer detection in high-risk patients with familial breast and ovarian cancer

Lux, Michael P.; Ackermann, S.; Nestle-Krämling, C.; Goecke, T O; Niederacher, Dieter; Bodden-Heidrich, R.; Beckmann, MW; Fasching, Peter A.

doi:10.1097/00008469-200508000-00014

Cited by 13 publications

(10 citation statements)

References 29 publications

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“…Two study centers screened for both breast and ovarian cancer [127][128][129][130][131] (Table 4). From the Stockholm center (BOC#1) which included 160 high-risk families, the decreasing age of cancer onset with successive generations was considered to be important for choosing surveillance modalities [127].…”

Section: Breast Cancer Edp Among Jewish Womenmentioning

confidence: 99%

Screening of high-risk groups for breast and ovarian cancer in Europe: a focus on the Jewish population

et al. 2010

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Low breast cancer screening rates are often found among ethnic minority groups and those born outside the host country. This is of particular concern for high-risk groups, who should benefit from ongoing trials aimed at optimizing screening strategies for breast, as well as ovarian cancer. Both of these issues are germane for Jewish women in Europe. We systematically review the literature concerning breast cancer early detection practices (BCEDP) among Jewish women, and examine European surveillance studies of high-risk for breast and/or ovarian cancer that had imaging in the surveillance protocol, in order to assess the likelihood of adequately including women from minority ethnic groups. No studies were found about BCEDP among Jewish women in Europe. Twenty-one research groups from Israel or the US addressed BCEDP among Jewish women. Some Jewish women in the US and Israel, including recent immigrants, are under-screened. Twenty-four research groups reported imaging surveillance of women at increased risk for breast and/or ovarian cancer in Europe. There was a clear benefit to magnetic resonance imaging and/or more intensive screening for women with increased breast cancer risk. Some of these surveillance studies considered ethnic minority groups at high risk, including Jewish women, but none provided adequate outreach to ensure that these groups were included in their programs. The specific screening needs of Jewish and other high-risk ethnic minority groups in Europe have not been met regarding breast and ovarian cancer. A European-wide, population-based approach is suggested, with cultural sensitivity being vital for these efforts.

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Section: Breast Cancer Edp Among Jewish Womenmentioning

confidence: 99%

Screening of high-risk groups for breast and ovarian cancer in Europe: a focus on the Jewish population

et al. 2010

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“…Notwithstanding the high frequency of surveillance, these authors found it feasible to motivate at-risk women to participate. despite the problems surrounding false positive findings, Mri was found to be acceptable by these women (84,85). This latter conclusion was shared by authors from the dutch Multicenter study (#1) (38).…”

Section: Benefits Of Imaging Surveillance For Women At High Breast Camentioning

confidence: 69%

“…The investigators from the dusseldorf Center (#13) (84,85) stated that intensified early cancer detection programs for women at risk provide a less invasive option than chemoprevention or prophylactic surgery. Notwithstanding the high frequency of surveillance, these authors found it feasible to motivate at-risk women to participate.…”

Section: Benefits Of Imaging Surveillance For Women At High Breast Camentioning

confidence: 99%

Imaging surveillance programs for women at high breast cancer risk in Europe: Are women from ethnic minority groups adequately included? (Review)

Belkić

Cohen

Wilczek

et al. 2015

International Journal of Oncology

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Abstract. Women from ethnic minority groups, including immigrants and refugees are reported to have low breast cancer (BC) screening rates. Active, culturally-sensitive outreach is vital for increasing participation of these women in BC screening programs. Women at high BC risk and who belong to an ethnic minority group are of special concern. Such women could benefit from ongoing trials aimed at optimizing screening strategies for early BC detection among those at increased BC risk. Considering the marked disparities in BC survival in Europe and its enormous and dynamic ethnic diversity, these issues are extremely timely for Europe. We systematically reviewed the literature concerning European surveillance studies that had imaging in the protocol and that targeted women at high BC risk. The aim of the present review was thereby to assess the likelihood that women at high BC risk from minority ethnic groups were adequately included in these surveillance programs. Twenty-seven research groups in Europe reported on their imaging surveillance programs for women at increased BC risk. The benefit of strategies such as inclusion of magnetic resonance imaging and/or more intensive screening was clearly documented for the participating women at increased BC risk. However, none of the reports indicated that sufficient outreach was performed to ensure that women at increased BC risk from minority ethnic groups were adequately included in these surveillance programs. On the basis of this systematic review, we conclude that the specific screening needs of ethnic minority women at increased BC risk have not yet been met in Europe. Active, culturally-sensitive outreach is needed to identify minority women at increased BC risk and to facilitate their inclusion in on-going surveillance programs. It is anticipated that these efforts would be most effective if coordinated with the development of European-wide, population-based approaches to BC screening. Contents

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“…For women at elevated ovarian cancer risk, due to heredity, ionizing radiation exposure, or other risk factors, FPT-MRS could also be suitable for surveillance. Aligned with this perspective is the view of women at high ovarian cancer risk [36,67], as well as of women from the general population [68], who have clearly expressed an interest and preference for screening surveillance strategies vis-à-vis ovarian cancer. Most essentially, the survival for women afflicted with ovarian cancer would be markedly improved with early detection of this malignancy.…”

Section: Discussionmentioning

confidence: 99%

Encoded in vivo time signals from the ovary in magnetic resonance spectroscopy: poles and zeros as the cornerstone for stability of response functions of systems to external perturbations

Belkić

2017

J Math Chem

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In order to handle encoded data from magnetic resonance spectroscopy (MRS), advanced signal processing methods are vital. This is presently carried out using the fast Padé transform (FPT) applied to in vivo MRS time signals encoded from the ovary. We examine the essential features of the response function, namely the spectral poles and zeros, as the key to stability of the system to external excitations. Noise is separated from signal by reliance upon the multi-level signature of Froissart doublets. Our focus is upon eliminating the oversensitivity to alterations in model order K , through systematic examination of poles and zeros, as well as Padé-reconstructed total shape spectra, spectral parameters and component shape spectra. This comprehensive examination of convergence of all variables under study includes investigation of the combined role of spectra averaging and time signal extrapolation. Comparisons are made throughout between the results for six model orders (K = 575, 585, . . . , 625) with an increment of ten and eleven model orders (K = 575, 580, . . . , 625) with an increment of 5. It is demonstrated that for the reconstructed poles and zeros, as well as for magnitudes and phases, spectra averaging and Padé-based extrapolation of time signals are essential for the stability of the system and for the accurate retrieval of resonances. Full convergence is achieved when spectra averaging and extrapolation are applied together. Spectra averaging and extrapolation are also shown to be needed to obtain stabilized results to the level of stochasticity for the component spectra for the six and the eleven model orders. Without spectra averaging and extrapolation, there were noticeable variances for the six and the eleven model orders with regard to all the variables under study. The present analysis and results have important implications for expediting the robust quantification by the FPT. All the analysis herein was applied to in vivo MRS data encoded on a 3 T scanner from a borderline serous cystic ovarian tumor. This clinical problem has been chosen in light of the urgent need to develop effective methods for early detection of ovarian cancer. The overriding motivation is to improve survival for women afflicted with this malignancy. The reported results further hone the Padé-designed methodology for practical applications of in vivo MRS and, therefore, are anticipated to help in achieving the stated goal.

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Use of intensified early cancer detection in high-risk patients with familial breast and ovarian cancer

Cited by 13 publications

References 29 publications

Screening of high-risk groups for breast and ovarian cancer in Europe: a focus on the Jewish population

Screening of high-risk groups for breast and ovarian cancer in Europe: a focus on the Jewish population

Imaging surveillance programs for women at high breast cancer risk in Europe: Are women from ethnic minority groups adequately included? (Review)

Encoded in vivo time signals from the ovary in magnetic resonance spectroscopy: poles and zeros as the cornerstone for stability of response functions of systems to external perturbations

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