Use of Intense Ultrasound in Neurological Research

Fry, William J.

doi:10.1097/00002060-195806000-00009

Cited by 37 publications

(25 citation statements)

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“…Ultrasound has been reported to have effects on auditory (Foster and Wiederhold, 1978;Gavrilov et al, 1975Gavrilov et al, , 1980Siddiqi et al, 1988Siddiqi et al, , 1990Tsirulnikov et al, 1988), visual (Fry et al, 1958), and tactile (Gavrilov et al, 1977a(Gavrilov et al, , b, 1984a sensations. The tactile studies by Gavrilov et al used focused ultrasound to produce sensations of touch, temperature, and pain.…”

Section: Introductionmentioning

confidence: 99%

Tactile perception of ultrasound

Dalecki

Child²,

Raeman³

et al. 1995

The Journal of the Acoustical Society of America

128

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In this investigation, acoustic radiation force was used as a stimulus to determine the threshold for tactile perception in the human finger and upper forearm as a function of frequency and pulse duration. Initially, a small (1.8-cm2) acoustically reflecting disk was affixed to the anatomical exposure site to maximize the delivered radiation force. Exposures were performed using a 2.2-MHz unfocused source modulated to produce square waves at 50, 100, 200, 500, and 1000 Hz. For the finger, maximum tactile sensitivity occurred at 200 Hz with a threshold radiation force of approximately 0.4 mN. For single pulses of 1 to 100 ms at 2.2 MHz, the threshold forces were an order of magnitude greater than for continuous exposure modulated at 200 Hz. Thresholds for pulse durations of 0.1 ms were somewhat greater than for pulses longer than 1 ms. Subsequently, thresholds of tactile perception were determined for direct exposure of the upper forearm (avoiding bone) to single pulses of 2.2-MHz ultrasound. Comparison of perception thresholds with and without a reflecting material over the tissue were consistent with the hypothesis that the tactile sensation experienced when tissue is exposed to ultrasound is its response to the radiation force associated with the transfer of momentum from the sound field to the tissue medium.

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Section: Introductionmentioning

confidence: 99%

Tactile perception of ultrasound

Dalecki

Child²,

Raeman³

et al. 1995

The Journal of the Acoustical Society of America

128

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“…Indeed, it was the first imaging modality used for guiding FUS interventions; X-ray imaging was effectively used by Fry et al . to target structures in the brain during early experiments of FUS therapy on patients with Parkinson’s disease and various other neurological afflictions [4, 5]. Fluoroscopy has been investigated for guiding ultrasonic catheter systems to the appropriate anatomical site [207, 208].…”

Section: Image Guidancementioning

confidence: 99%

“…Although the ability of focused ultrasound (FUS) to induce localized tissue coagulation was first demonstrated over 70 years ago [2, 3], its clinical adoption has been slow to date. The first clinical device utilized FUS beams, guided by X-rays and bony landmarks, to thermally coagulate dysfunctional tissues [4, 5]. In these early human studies, it was demonstrated that FUS can be used to selectively ablate targeted regions while sparing surrounding and overlying tissues.…”

Section: Introductionmentioning

confidence: 99%

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

Hynynen¹,

Jones²

2016

Phys. Med. Biol.

103

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Focused ultrasound offers a non-invasive way of depositing acoustic energy deep into the body, which can be harnessed for a broad spectrum of therapeutic purposes, including tissue ablation, the targeting of therapeutic agents, and stem cell delivery. Phased array transducers enable electronic control over the beam geometry and direction, and can be tailored to provide optimal energy deposition patterns for a given therapeutic application. Their use in combination with modern medical imaging for therapy guidance allows precise targeting, online monitoring, and post-treatment evaluation of the ultrasound-mediated bioeffects. In the past there have been some technical obstacles hindering the construction of large aperture, high-power, densely-populated phased arrays and, as a result, they have not been fully exploited for therapy delivery to date. However, recent research has made the construction of such arrays feasible, and it is expected that their continued development will both greatly improve the safety and efficacy of existing ultrasound therapies as well as enable treatments that are not currently possible with existing technology. This review will summarize the basic principles, current statures, and future potential of image-guided ultrasound phased arrays for therapy.

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“…These studies were further developed in the same laboratory [3][4][5][6]. In particular, it was shown [4] that the effect of focused ultrasound of relatively high intensity on the lateral geniculate nucleus of a cat's brain causes reversible inhibition of electrical responses in the visual cortex to light stimulation of the eyes.…”

Section: Focused Ultrasound As a Tool To Input Sensory Information Tomentioning

confidence: 99%

Focused ultrasound as a tool to input sensory information to humans (Review)

Гаврилов

Tsirulnikov

2012

Acoust. Phys.

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This review is devoted to the analysis of studies and implementations related to the use of focused ultrasound for functional effects on neuroreceptor structures. Special attention was paid to the stimulation of neuroreceptor structures in order to input sensory information to humans. This branch of medical and phys iological acoustics appeared in Russia in the early 1970s and was being efficiently developed up to the late 1980s. Then, due to lack of financial support, only individual researchers remained at this field and, as a result, we have no full fledged theoretical research and practical implementations in this area yet. Many promising possibilities of using functional effects of focused ultrasound in medicine and physiology have remained unimplemented for a long time. However, new interesting ideas and approaches have appeared in recent years. Very recently, very questionable projects have been reported related to the use of ultrasound for targeted functional effects on the human brain performed in some laboratories. In this review, the stages of the development of scientific research devoted to the functional effects of focused ultrasound are described. By activating the neuroreceptor structures of the skin by means pulses of focused ultrasound, one can cause all the sensations perceived by human beings through the skin in everyday life, such as tactile sensations, ther mal (heat and cold), tickling, itching, and various types of pain. Stimulation of the ear labyrinth of humans with normal hearing using amplitude modulated ultrasound causes auditory sensations corresponding to an audio modulating signal (pure tones, music, speech, etc.). Activation of neuroreceptor structures by means of focused ultrasound is used for the diagnosis of various neurological and skin diseases, as well as hearing dis orders. It has been shown that the activation is related to the mechanical action of ultrasound, for example, by the radiation force, as well as to the direct action of ultrasonic vibrations on nerve fibers. The action of the radiation force is promising for the realization of the possibility of blind and even deaf and blind people to perceive text information on a display using tactile sensations caused by ultrasound. Very different methods of using ultrasound for local stimulation of neuroreceptor structures are discussed in this review. Among them are practical methods that have been already tested in a clinic, as well as pretending to be sensational methods that are hardly feasible in the foreseeable future.

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Use of Intense Ultrasound in Neurological Research

Cited by 37 publications

References 0 publications

Tactile perception of ultrasound

Tactile perception of ultrasound

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy

Focused ultrasound as a tool to input sensory information to humans (Review)

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