Use of Insulin Glargine During Pregnancy in Seven Type 1 Diabetic Women

Woolderink, Jorien M.; Loon, A.J. van; Storms, F.; Heide, Loek de; Hoogenberg, Klaas

doi:10.2337/diacare.28.10.2594

Cited by 42 publications

(25 citation statements)

References 8 publications

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“…Treatment with aspart was at least as safe as human insulin regarding perinatal outcome [6]. Only case reports on the use of glargine during pregnancy were found in the literature: a total of six diabetic type 1 patients were treated with glargine during the whole pregnancy [7,8]; in five other patients it was used during [9] and in four patients after the first trimester [7,[10][11]. All the women delivered newborns without malformations.…”

Section: The Insulin Analog Glargine During An Unplanned Pregnancymentioning

confidence: 97%

The insulin analog glargine during an unplanned pregnancy

Cechurová¹,

Lacigová²,

Jankovec³

et al. 2006

Wien Klin Wochenschr

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Section: The Insulin Analog Glargine During An Unplanned Pregnancymentioning

confidence: 97%

The insulin analog glargine during an unplanned pregnancy

Cechurová¹,

Lacigová²,

Jankovec³

et al. 2006

Wien Klin Wochenschr

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“…Por lo que respecta al tipo de insulina a utilizar, se recomienda la insulina humana; sin embargo, varios estudios apoyan tanto la seguridad como la eficacia de los análogos de insulina rápida (lispro y aspártica) en el embarazo [16][17][18][19][20][21][22][23][24][25][26][27] , consiguiendo los objetivos de control posprandiales con menor riesgo de hipoglucemias. -Así mismo, hay diferentes estudios con el uso de análogos de insulina lenta en el embarazo [28][29][30][31][32][33][34][35][36][37] , destacando entre ellos un metaanálisis de insulina glargina en el que no se encuentran un aumento de efectos adversos en los resultados perinatales en comparación con NPH 34 , y un ensayo clínico con insulina detemir que demuestra la seguridad y la eficacia de esta insulina en el embarazo y tiene aprobada la indicación en el embarazo por la Food and Drug Administration (FDA) 35,37 . Por este motivo, las mujeres que estén en tratamiento con análogos de insulina basales y tengan un buen control glucémico antes de la gestación podrían seguir con el tratamiento durante el periodo preconcepcional y durante la gestación.…”

Section: Control Metabólico De La Dmpgunclassified

Asistencia a la gestante con diabetes. Guía de práctica clínica actualizada en 2014

Acosta

Balsells

Ballesteros

et al. 2015

Avances en Diabetología

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“…No large randomized clinical trials with insulin glargine used during pregnancy have been done up to now (21). It was also proven that insulin glargine does not cross the placenta (39), and many studies with small number of patients have shown the safety and efficacy of its use in pregnancy (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)56). Negrato and cols.…”

Section: Insulin Glarginementioning

confidence: 99%

Insulin analogues in the treatment of diabetes in pregnancy

Negrato¹,

Montenegro

Kostrisch

et al. 2012

Arq Bras Endocrinol Metab

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SUMMARYPregnancy affects both maternal and fetal metabolism, and even in non-diabetic women, it exerts a diabetogenic effect. Among pregnant women, 2% to 14% develop gestational diabetes. Pregnancy can also occur in women with preexisting diabetes, which may predispose the fetus to many alterations in organogenesis, restrict growth, and the mother, to some diabetes-related complications, such as retinopathy and nephropathy, or to acceleration of the course of these complications, if they are already present. Women with gestational diabetes generally start their treatment with diet and lifestyle changes; when these changes are not enough for optimal glycemic control, insulin therapy must then be considered. Women with type 2 diabetes using oral hypoglycemic agents are advised to change to insulin therapy. Those with preexisting type 1 diabetes should start intensive glycemic control. As basal insulin analogues have frequently been used off-label in pregnant women, there is a need to evaluate their safety and efficacy. The aim of this review is to report the use of both short-and long-acting insulin analogues during pregnancy and to enable clinicians, obstetricians, and endocrinologists to choose the best insulin treatment for their patients. Arq Bras Endocrinol Metab. 2012;56(7):405-14 Keywords Type 1 diabetes; type 2 diabetes; gestational diabetes; insulin analogues; insulin lispro; insulin aspart; insulin glulisine; insulin glargine; insulin detemir SUMÁRIO A gravidez afeta tanto o metabolismo materno quanto o fetal e, mesmo em mulheres não diabéticas, apresenta um efeito diabetogênico. Entre as mulheres grávidas, 2% a 14% desenvolvem o diabetes gestacional. A gravidez pode ocorrer também em mulheres já diabéticas, o que pode predispor o feto a muitas alterações na organogênese, restrição de crescimento e a mãe a algumas complicações relacionadas ao diabetes, tais como retinopatia e nefropatia, ou acelerar o curso dessas complicações se já estiverem presentes. Pacientes com diabetes gestacional geralmente iniciam seu tratamento com dieta e mudanças no estilo de vida; porém, quando essas medidas falham em atingir um controle glicêmico adequado, a insulinoterapia deve ser considerada. Pacientes com diabetes tipo 2 em uso de hipoglicemiantes orais são aconselhadas a iniciar o uso de insulina. Pacientes com diabetes tipo 1 preexistente devem iniciar um controle glicêmico estrito. Em função do fato de os análogos basais de insulina estarem sendo utilizados muito frequentemente off-label em pacientes grávidas, faz-se necessário avaliar sua segurança e eficácia nessa condição. O objetivo desta revisão é avaliar o uso de tais análogos, tanto de ação curta como prolongada, durante a gravidez, para possibilitar médicos clínicos, obstetras e endocrinologistas escolher o melhor regime terapêutico para suas pacientes. Arq Bras Endocrinol Metab. 2012;56(7):405-14 Descritores Diabetes tipo 1; diabetes tipo 2; diabetes

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Use of Insulin Glargine During Pregnancy in Seven Type 1 Diabetic Women

Abstract: Potential role of glial cell linederived neurotrophic factor receptors in Mü ller glial cells during light-induced retinal degeneration.

Cited by 42 publications

References 8 publications

The insulin analog glargine during an unplanned pregnancy

The insulin analog glargine during an unplanned pregnancy

Asistencia a la gestante con diabetes. Guía de práctica clínica actualizada en 2014

Insulin analogues in the treatment of diabetes in pregnancy

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