Use of inhaled nitric oxide in British intensive therapy units

Cuthbertson, Brian H.; Stott, S; Webster, Nigel R.

doi:10.1093/bja/78.6.696

Cited by 22 publications

(12 citation statements)

References 20 publications

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“…The positive effect of inhaled NO on arterial oxygenation has probably been the most important reason for the widespread use [3] of INO in ARDS patients in Europe during the last years.…”

Section: Day 30mentioning

confidence: 99%

“…It also improves oxygenation and decreases pulmonary hypertension in patients with the acute respiratory distress syndrome (ARDS ) [2]. Numerous studies have confirmed these findings and INO is now often used in the treatment of patients with acute lung injury (ALI) and ARDS [3]. Despite its well documented physiological effects, it is important to evaluate whether INO is safe to use and whether it improves outcome in patients with ALI.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhalation of nitric oxide in acute lung injury: results of a European multicentre study

et al. 1999

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“…The positive effect of inhaled NO on arterial oxygenation has probably been the most important reason for the widespread use [3] of INO in ARDS patients in Europe during the last years.…”

Section: Day 30mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhalation of nitric oxide in acute lung injury: results of a European multicentre study

et al. 1999

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“…The current safety regulation for environmental NO gas is 25 ppm [1]. Moreover, NO also plays an important role in the physiological responses of our body.…”

Section: Introductionmentioning

confidence: 99%

NO gas sensor of PEDOT: PSS nanowires by using direct patterning DPN

Lin

Fang

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Nitric oxide (NO) detection is a critical issue for environmental safety and medical diagnosis due reasons with regard to the toxic properties for human body and metabolic index for respiratory disease, respectively. Development of gas sensor with high sensitivity is very important because the concentration of NO gas in the environment and respiratory tract is extremely low, therefore not readily detectable. The material with nanostructure can improve the sensitivity of sensor owning to surface effect and size effect. Herein, we developed a new type of gaseous nanosensor assembled by 34 nanowires of conducting polymer, PEDOT: PSS. The nanowires were fabricated by dip pen nanolithography (DPN) with the length of 55 um and diameter of 300 nm between golden wires. The NO gas measurement is based on chemiresistor based methods. The result of dynamic measurement of NO gas at 100 ppm shows repeatability and stability; the recovery time is 10.4 minutes. Moreover, the lowest concentration of NO gas in static measurement is 10ppm at 80 C, which also shows the ability sensing at low temperature.

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“…It is also an important index in diagnosis of the chronic respiratory disease, asthma. However, its detection is rather difficult due to its extremely low concentration, which is about 20ppb [1,2]. The traditional method that was used to detect NO gas was based on measuring its variation of electrical conductivity.…”

Section: Introductionmentioning

confidence: 99%

Surface plasmon resonance biochip based on ZnO thin film for nitric oxide sensing

Feng

Chiu

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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In this study, the design of a novel optical sensor that comprises surface plasmon resonance sensing chip and zinc oxide nano-film was proposed for the detection of nitric oxide gas. The electrical and optical properties of zinc oxide film vary in the presence of nitric oxide. This effect was utilized to prepare biochemical sensors with transduction based on surface plasmon resonance. Due to the refractive index of the transparent zinc oxide film that was deposited on the gold film, however, changes will be observed in the surface plasmon resonance spectra. For this reason, the thickness of zinc oxide film will be investigated and determined in this study. The interaction of nitric oxide with a 20 nm zinc oxide layer on gold leads to the shift of the resonance angle. The analysis on the reflectance intensity of light demonstrates that such effect is caused by the variation of conductivity and permittivity of zinc oxide film. Finally, a shift in surface plasmon resonance angle was measured in 25 ppm nitric oxide at 180 C and a calibration curve of nitride oxide concentration versus response intensity was successfully obtained in the range of 250 to 1000 ppm nitric oxide at lower temperature of 150 C. Moreover, these effects are quasi-reversible.

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Use of inhaled nitric oxide in British intensive therapy units

Cited by 22 publications

References 20 publications

Inhalation of nitric oxide in acute lung injury: results of a European multicentre study

Inhalation of nitric oxide in acute lung injury: results of a European multicentre study

NO gas sensor of PEDOT: PSS nanowires by using direct patterning DPN

Surface plasmon resonance biochip based on ZnO thin film for nitric oxide sensing

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