Use of individualized 3D-printed models of pancreatic cancer to improve surgeons’ anatomic understanding and surgical planning

Song, C.; Min, Ji Hye; Jeong, Woo Kyoung; Kim, Seong Hyun; Heo, Jin Seok; Han, In Woong; Shin, Sang Hyun; Yoon, So Jeong; Choi, Sung Yong; Moon, Seong Yong

doi:10.1007/s00330-023-09756-0

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…This discrepancy can be attributed to the complex nature of soft-tissue structures, the challenges associated with replicating their intricate features [ 1 ], and the limited availability of suitable biocompatible materials for 3D printing. Although the integration of 3D printing technology into soft-tissue surgeries, like abdominal procedures, has been documented and the benefits noted [ 2 ], 3D printing remains an area of ongoing research and exploration. While the number of published articles is rising in recent years, most of the articles are focused on liver and kidney models.…”

Section: Discussionmentioning

confidence: 99%

Enhancing surgical planning of distal splenopancreatectomy through 3D printed models: a case report

Arsenkov,

Plavevski,

Nikolovski

et al. 2023

Journal of Surgical Case Reports

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The complex anatomy of the peripancreatic region was a challenge to many surgeons in the past. Up until recently, the only way to prepare and plan a surgery was through the use of traditional 2D images, obtained via computed tomography or magnetic resonance imaging. Recently, the advantages in the field of 3D printing (also called additive manufacturing, or rapid prototyping) allowed the creation of replicas of the patient’s anatomy which is to be used for preoperative planning and visual reference. We present the case of a 46-y.o. patient with a distal pancreatic lesion requiring a distal splenopancreatectomy, who benefited from the use of 3D printing technology. No intraoperative or postoperative complications were encountered, while the created model was used to plan and perform the needed resection.

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Section: Discussionmentioning

confidence: 99%

Enhancing surgical planning of distal splenopancreatectomy through 3D printed models: a case report

Arsenkov,

Plavevski,

Nikolovski

et al. 2023

Journal of Surgical Case Reports

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“…Fang et al showed that the use of the Medical Image 3D Visualization System (MI-3DVS) allowed for a better assessment of resectable PDAC, with an accuracy of 100% compared to that of CT angiography, with an accuracy of 82.5% only ( 23 ). Images obtained from 3D reconstruction can also be printed out as 3D models to allow surgeons to better visualise and plan for surgery ( 24 ). Other uses include the ability of AI to predict post-operative complications, especially POPF.…”

mentioning

confidence: 99%

Is open pancreatic surgery still relevant now in the era of minimally invasive pancreatic surgery?

Chan,

Shelat,

Junnarkar

2024

Gland Surg

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High‐Resolution 3D Printing of Pancreatic Ductal Microanatomy Enabled by Serial Histology

Kiemen,

Forjaz,

Sousa

et al. 2024

Adv Materials Technologies

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Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer that can develop from pancreatic intraepithelial neoplasia (PanIN), a microscopic lesion in the pancreatic ductal system. PanIN and PDAC are conventionally studied in 2D via histological tissue sections. As such, their true structure is poorly understood due to the inability to image them in 3D. CODA, a recently developed technique for reconstruction of tissues at cellular resolution, is used to study the 3D morphology of the pancreas. Here, CODA is extended through 3D printing of normal pancreatic ducts, PanIN, and PDAC at cm‐scale and µm resolution. A methodology is presented to create 3D printable files from anatomical maps generated from serial histological images and to show detailed validation of the accuracy of this method. Existing 3D printing workflows utilizing medical images derived from computerized tomography (CT), X‐ray, and magnetic resonance imaging (MRI) are scientifically proven to be useful in printing whole organ‐scale structures with sub‐mm resolution. Here, using serial histological sections, it is demonstrated that 3D printing of higher‐resolution structures is also possible. Finally, with the 3D models of normal ducts, PanIN, and PDAC, marked changes to the structure of the human pancreas during tumorigenesis are revealed.

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Use of individualized 3D-printed models of pancreatic cancer to improve surgeons’ anatomic understanding and surgical planning

Cited by 4 publications

References 40 publications

Enhancing surgical planning of distal splenopancreatectomy through 3D printed models: a case report

Enhancing surgical planning of distal splenopancreatectomy through 3D printed models: a case report

Is open pancreatic surgery still relevant now in the era of minimally invasive pancreatic surgery?

High‐Resolution 3D Printing of Pancreatic Ductal Microanatomy Enabled by Serial Histology

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