Use of Indium-111-Labeled Cells in Measurement of Cellular Dynamics of Experimental Cardiac Allograft Rejection

Oluwole, Soji F.; Wang, Theodore; Fawwaz, Rashid A.; Satake, K; Nowygrod, Roman; Reemtsma, K; Hardy, Mark A.

doi:10.1097/00007890-198101000-00012

Cited by 27 publications

(7 citation statements)

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“…A single experimental study of organ transplantation has been reported by Oluwole and his co-workers. 66,67 The scintigrams of heterotopic cardiac allografts in rats exhibited platelet uptake during the period of rejection, 5 to 7 days after surgery. Syngeneic grafts showed no uptake and no rejection.…”

Section: Experimental Studiesmentioning

confidence: 99%

Thrombus Imaging With Indium-111 Platelets

Siegel

1983

Semin Thromb Hemost

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Section: Experimental Studiesmentioning

confidence: 99%

Thrombus Imaging With Indium-111 Platelets

Siegel

1983

Semin Thromb Hemost

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“…1,2 Subsequent to these reports, radioactively labeled platelets were used to demonstrate that platelet accumulation was an early indicator of transplant rejection. 3,4 More recent studies have also described intravascular platelet aggregates in clinical and experimental models of antibody-mediated rejection. 5,6 When immunohistology is used to detect platelet markers, the majority of biopsies from renal transplants contain platelet aggregates in peritubular capillaries.…”

mentioning

confidence: 99%

In Vivo Platelet–Endothelial Cell Interactions in Response to Major Histocompatibility Complex Alloantibody

Morrell

Murata

Swaim

et al. 2008

Circulation Research

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“…Early pathological descriptions of transplants recognized the presence of platelets in kidney transplants (7) and a number of studies followed in which platelets were labeled with indium to track their accumulation in renal allografts (8, 9). These studies led to the general observation that platelets accumulate in renal allografts and may be markers of graft rejection.…”

Section: Introductionmentioning

confidence: 99%

Platelets Contribute to Allograft Rejection through Glutamate Receptor Signaling

Swaim¹,

Field

Fox-Talbot

et al. 2010

The Journal of Immunology

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Platelets recruit leukocytes and mediate interactions between leukocytes and endothelial cells. Platelets have been long described as markers of transplant rejection, but the contribution of platelets to transplant rejection has not been critically examined. We now demonstrate that following T-cell initiation of allograft rejection platelets contribute to T-cell recruitment, increased plasma inflammatory mediators, and accelerate T-cell meditated skin graft rejection. Prior work from our lab has shown that platelets secrete glutamate when activated, which then induces platelet thromboxane production by signaling through platelet expressed ionotropic glutamate receptors. Glutamate receptor antagonists therefore represent novel inhibitors of platelet accelerated inflammation. We have found that plasma glutamate is increased in mice that receive skin grafts and that mice treated with glutamate receptor antagonists have improved graft survival and decreased plasma thromboxane, platelet factor 4 (PF4/CXCL4) and IFNγ. Taken together, our work now demonstrates that subsequent to T-cell initiation of skin graft rejection, platelets contribute to further T-cell recruitment and that by blunting glutamate mediated platelet activation, graft survival is improved.

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Use of Indium-111-Labeled Cells in Measurement of Cellular Dynamics of Experimental Cardiac Allograft Rejection

Cited by 27 publications

References 0 publications

Thrombus Imaging With Indium-111 Platelets

Thrombus Imaging With Indium-111 Platelets

In Vivo Platelet–Endothelial Cell Interactions in Response to Major Histocompatibility Complex Alloantibody

Platelets Contribute to Allograft Rejection through Glutamate Receptor Signaling

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