2004
DOI: 10.1001/archderm.140.9.1127
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Use of In Vivo Confocal Microscopy in Malignant Melanoma

Abstract: Background: Melanomas with poorly defined borders, lack of pigmentation, lentiginous extension, and location in cosmetically sensitive regions represent diagnostic and therapeutic challenges. Repeated surgical reexcisions are frequently required to achieve tumorfree margins. The use of reflectance mode confocal microscopy as an noninvasive method has shown to be a promising tool for diagnosing pigmented lesions in vivo.Observations: We report 3 clinical cases of melanoma: amelanotic melanoma (case 1), locally … Show more

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Cited by 126 publications
(22 citation statements)
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References 19 publications
(27 reference statements)
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“…Its mode of action implies the induction of the innate immunity resulting in a selective antitumoral immune response through the activation of dendritic cells, cytotoxic T lymphocytes and proinflammatory cytokines. RCM has been used for monitoring and evaluation of treatment efficacy of basal cell carcinoma and lentigo maligna melanoma during topical IMIQ therapy [36,37,38]. To our knowledge, no systematic RCM evaluation of treatment response of AK to IMIQ has been performed.…”
Section: Discussionmentioning
confidence: 99%
“…Its mode of action implies the induction of the innate immunity resulting in a selective antitumoral immune response through the activation of dendritic cells, cytotoxic T lymphocytes and proinflammatory cytokines. RCM has been used for monitoring and evaluation of treatment efficacy of basal cell carcinoma and lentigo maligna melanoma during topical IMIQ therapy [36,37,38]. To our knowledge, no systematic RCM evaluation of treatment response of AK to IMIQ has been performed.…”
Section: Discussionmentioning
confidence: 99%
“…The examination of the distribution and morphology of melanocytes under in vivo reflectance confocal microscopy (RCM) improves our ability to recognize early melanoma at the bedside 15 . As with any imaging modality, however, RCM evaluation may give rise to false-positive or false-negative results, discordant with the final histopathologic diagnosis.…”
Section: Introductionmentioning
confidence: 99%
“…Increased clinical application of CLSM is anticipated [15,[23][24][25][26][27]. In this study, reconstructed images of given sections were converted into three-dimensions using the data set of a large number of tomograms in the horizontal directions.…”
Section: Discussionmentioning
confidence: 99%