Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

Meynard, J.; Amado-Becker, F.; Tchoreloff, Pierre; Mazel, Vincent

doi:10.1016/j.ijpharm.2021.120797

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…While vibration methods, inspired by mechanical and acoustic engineers, have been explored for determining elastic properties (Table 2), their application in this context remains relatively understudied. More recent studies have applied vibration methods to study the elastic and viscoelastic behavior of tablets [46,49,50]. To the authors, the development of low-consolidation methodologies appears highly relevant, considering many situations where powders are in loose packing conditions, such as during transport, storage, and feeding.…”

Section: Exploring the Complexity: Consistency And Challenges In Youn...mentioning

confidence: 99%

“…Indeed, the acoustic response of granular materials has been extensively explored by mechanics groups to determine damping and energy dissipation, with major applications in aeronautics [48]. To our knowledge, powder technology groups have not extensively utilized this type of technology, with recent studies primarily focused on pharmaceutical applications, particularly tablets rather than the powder itself [46,49,50].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Consistency in Young’s Modulus of Powders: A Review with Experiments

Cares-Pacheco,

Cordeiro-Silva,

Gerardin

et al. 2024

Powders

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This review, complemented by empirical investigations, delves into the intricate world of industrial powders, examining their elastic properties through diverse methodologies. The study critically assesses Young’s modulus (E) across eight different powder samples from various industries, including joint filler, wheat flour, wheat starch, gluten, glass beads, and sericite. Employing a multidisciplinary approach, integrating uniaxial compression methodologies—both single and cyclic—with vibration techniques, has revealed surprising insights. Particularly notable is the relationship between porosity and Young’s modulus, linking loose powders to the compacts generated under compression methods. Depending on the porosity of the powder bed, Young’s modulus can vary from a few MPa (loose powder) to several GPa (tablet), following an exponential trend. The discussion emphasizes the necessity of integrating various techniques, with a specific focus on the consolidation state of the powder bed, to achieve a comprehensive understanding of bulk elasticity. This underscores the need for low-consolidation methodologies that align more closely with powder technologies and unit operations such as conveying, transport, storage, and feeding. In conclusion, the study suggests avenues for further research, highlighting the importance of exploring bulk elastic properties in loose packing conditions, their relation with flowability, alongside the significance of powder conditioning.

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Section: Exploring the Complexity: Consistency And Challenges In Youn...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Consistency in Young’s Modulus of Powders: A Review with Experiments

Cares-Pacheco,

Cordeiro-Silva,

Gerardin

et al. 2024

Powders

View full text Add to dashboard Cite

show abstract

“…In contrast, nondestructive methods such as vibration tests [18] or ultrasonic tests are practical alternatives for characterizing anisotropy in SLM components, offering shorter testing times and lower costs. The precision of the vibration method for anisotropy characterization is limited [19], thus increasing attention is being given to the use of ultrasonic waves for nondestructive characterization of material anisotropy. Recent studies by Thompson et al [20] explored the use of acoustic birefringence to evaluate residual stress-induced anisotropy, while Deng and Yang [21] utilized nonlinear Lamb wave approaches to characterize in-plane elastic anisotropy in solid plates.…”

Section: Introductionmentioning

confidence: 99%

Non-contact characterization of material anisotropy of additive manufacturing components by electromagnetic acoustic resonance technique

Yuan,

Li,

Deng

2023

Meas. Sci. Technol.

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The degree of material anisotropy in additive manufacturing (AM) components is greatly influenced by the AM process parameters and machine setup. It is crucial to develop an effective technique for evaluating the material anisotropy in AM components to optimize AM process parameters and component design. This paper proposed a non-contact ultrasonic characterization method using the electromagnetic acoustic resonance (EMAR) technique to characterize the anisotropy of AM components. Various electromagnetic acoustic transducers (EMATs) were designed and utilized to characterize the material anisotropy and to determine the principal direction of the AM components. The degree of anisotropy in AM components was characterized using radial radiation EMATs. The relationship between the degree of anisotropy and the laser scanning angle was explored and further determined through the acoustic birefringence factor (ABF). Experimental results demonstrated that the anisotropy of AM components is intricately associated with the laser scanning angle, and specific angles can render the AM components isotropic. Moreover, understanding the principal directions is of significance for structural design and analyzing stress distribution in anisotropic components. Therefore, the principal directions of AM components were obtained by rotating the linear polarization EMAT. Changes in the resonance spectrum captured by the linear polarization EMAT while evaluating of principal directions were clearly illustrated, despite negligible alterations in linear ultrasonic features. Metallographic diagrams further validated the experimental findings. This investigation presented a highly accurate and reliable alternative for characterizing the anisotropy of AM components.

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“…Paul adopted machine learning and multivariate instrumental analysis to investigate the correlation between tablet top cracking and pressure level, radial stress transfer, and mechanical properties of excipients to establish a tablet prediction model [6]. Meynard established a reliable analytical model based on Impulse Excitation Technique (IET) and nite element method (FEM) to investigate the correlation between different shapes and sizes of tablets and the occurrence of quality defects and the results indicate that special-shaped tablets are more easily to occur with quality defects [7]. However, due to the complex composition and diverse appearance structure of tablets, the methods above are also unable to reveal essentially the root reasons causing the quality differences.…”

Section: Introductionmentioning

confidence: 99%

Evolution characteristics of micromechanics provides insights into the microstructure of pharmaceutical tablets fabricated by bimodal mixtures

Zhao

Luo

et al. 2023

Preprint

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This research focuses on the evolution of mechanical behavior of bimodal mixtures undergoing compaction and diametrical compression. The clusters were built and discrete element modeling (DEM) was used to investigate the densification process and micromechanics of bimodal mixtures. Additionally, a more comprehensive investigate of the respective breakage of the bimodal mixtures has been carried out. On this basis, qualitative and quantitative analysis of the stress, force chain, contact bonds and density field evolution characteristics of the clusters are investigated during the compression process. The entire loading process of the clusters is divided into three stages: rearrangement, breakage and elastic-plastic deformation. Additionally, there are differences in the evolution of micromechanics behavior of different particles in the bimodal mixture, with PGS breakage and deformation occurring before MCC. With the tablet deformation, the fragmentation process of the tablet started at the point of contact and extended toward the center, and the curvature of the force chain increased. This approach may potentially hold a valuable new information relevant to important transformation forms batch manufacturing to advanced manufacturing for the oral solid dosage form.

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Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

Cited by 11 publications

References 32 publications

Consistency in Young’s Modulus of Powders: A Review with Experiments

Consistency in Young’s Modulus of Powders: A Review with Experiments

Non-contact characterization of material anisotropy of additive manufacturing components by electromagnetic acoustic resonance technique

Evolution characteristics of micromechanics provides insights into the microstructure of pharmaceutical tablets fabricated by bimodal mixtures

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