Use of Imidazoline Nitroxides in Studies of Chemical Reactions ESR Measurements of the Concentration and Reactivity of Protons, Thiols, and Nitric Oxide

Khramtsov, Valery V.; Volodarsky, L. B.

doi:10.1007/0-306-47072-1_4

Cited by 46 publications

(57 citation statements)

References 119 publications

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“…The pH values of solutions inside pores and near the surface of the studied inorganic and organo-inorganic materials were determined using spin probes, namely, pH-sensitive NRs of the imidazoline (R1, R2) and imidazolidine (R3) types (Table 3), which were synthesized at the Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (Volodarskii et al, 1988;Khramtsov et al, 1998;Kirilyuk et al, 2005).…”

Section: Ph Probesmentioning

confidence: 99%

pH-Sensitive Nitroxide Radicals for Studying Inorganic and Organo-Inorganic Materials and Systems

Kovaleva¹,

Молочников²

2012

Nitroxides - Theory, Experiment and Applications

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Section: Ph Probesmentioning

confidence: 99%

pH-Sensitive Nitroxide Radicals for Studying Inorganic and Organo-Inorganic Materials and Systems

Kovaleva¹,

Молочников²

2012

Nitroxides - Theory, Experiment and Applications

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“…Also temporal changes in the ESR spectrum of NR provide evidence for simultaneous reception of electron and proton from HQ and HS. Otherwise, the spectrum of protonated NR Tempo would have been observed (Khramtsov and Volodarsky, 1998). Therefore, the reduction of the spin concentration of NR seems to be induced by proton and electron transfers from HS to NR.…”

Section: Increase In the Concentration Of Soil Or Influenced By Nrmentioning

confidence: 98%

Spin labeling ESR investigation of the molecular environment of soil interacting with chemical organic contaminants

Aleksandrova

2013

Journal of Geochemical Exploration

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This manuscript elucidates the influence of special functional groups of organic xenobiotic chemicals on partly simultaneous molecular binding mechanisms. Organic xenobiotics are released as contaminants into the environment and are partially bound to soil constituents, such as humic substances (HS) and the mineral phase. The interaction of chemical contaminants with HS of soil was investigated using a labeling technique of soil samples with stable nitroxide radicals as model contaminants. These nitroxide radicals only differed in one functionality, a hydroxy or an amino functional group. Electron spin resonance (ESR) analyses of contaminated soil samples showed that the interaction was a multistage process that comprised an initial increase in the concentration of free organic radicals of soil influenced by contaminants with hydroxy or amino functionality, a decrease in the polarity of the molecular environment of soil, and a change in mobility of contaminant molecules. Towards the end of interaction, the concentration of free organic radicals usually decreased. Binding of contaminants to soil constituents via specific functionality was revealed detecting a change in their ESR spectra. Basing on the ESR analyses, a two-way exchange of protons' electron pairs between contaminants and HS was hypothesized to interpret the beginning of interaction.

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“…Recently, one of the most effective methods for the detection and quantification of NO in biological tissues is the method of electron paramagnetic resonance (Vanin et al 2002Khramtsov andVolodarsky 1998). Using the technique of spin traps, it allows the detection of NO in low concentrations (Mikoyan et al 1997).…”

Section: Formation Of the Complex Of No With The Spin Trap In Rat Tismentioning

confidence: 99%

Participation of NO-synthase in Control of Nitric Oxide Level in Rat Hippocampus after Modelling of Ischaemic and Haemorrhagic Insult

Гайнутдинов¹,

Pashkevich²,

Андрианов³

et al. 2017

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Electron paramagnetic resonance (EPR) was used as a method for recording the content of the nitric oxide (NO) in hippocampal tissues of intact rats and rats after modelling of ischaemic and haemorrhagic stroke. Based on direct measurements of NO by EPR spectroscopy, it was shown that, within 5 hours after the onset of symptoms of ischaemic and haemorrhagic stroke, the formation of NO in the hippocampus was reduced by a factor of 2-3 and this reduction was maintained for a period of between 24 and 72 hours. The results show that a systemic character of a decrease in the intensity of NO production during the modelling of ischaemic events in the brain reflects the effects of central dysregulation of the functions at the level of the whole organism such that it is appropriate to consider implementing the correction of the vital systems of the body in a stroke. It has indicated that non-selective NO-synthase blocker L-NAME reduced the low level of NO production by a factor of 3 by its administration within 72 hours after post-ischaemic and haemorrhagic stroke. It was discovered however that L-NAME returns the level of NO production to baseline (control) by its administration within 5 hours after ischaemia.

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Use of Imidazoline Nitroxides in Studies of Chemical Reactions ESR Measurements of the Concentration and Reactivity of Protons, Thiols, and Nitric Oxide

Cited by 46 publications

References 119 publications

pH-Sensitive Nitroxide Radicals for Studying Inorganic and Organo-Inorganic Materials and Systems

pH-Sensitive Nitroxide Radicals for Studying Inorganic and Organo-Inorganic Materials and Systems

Spin labeling ESR investigation of the molecular environment of soil interacting with chemical organic contaminants

Participation of NO-synthase in Control of Nitric Oxide Level in Rat Hippocampus after Modelling of Ischaemic and Haemorrhagic Insult

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