Use of IGIV in the Treatment of Immune-Mediated Dermatologic Disorders

Gelfand, Erwin W.

doi:10.1111/j.1087-0024.2004.00834.x

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…The therapeutic action of administrated immunoglobulin is probably related to the binding of the Fc portion of the immunoglobulin to Fc receptors and to its modulation effects in the activation and functioning of B lymphocytes 58 . Immunoglobulin also neutralizes pathogenic autoantibodies and has a strong anti‐inflammatory effect depending on its interactions with the complement system, cytokines and endothelial cells 91–93 . In our cases, the first four of the 17 patients were not treated with i.v.…”

Section: Symptoms Of Respiratory System and Prognosismentioning

confidence: 80%

Paraneoplastic pemphigus

Zhu¹,

ZHANG²

2007

The Journal of Dermatology

130

114

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Paraneoplastic pemphigus (PNP) is a life-threatening autoimmune blistering skin disease. Clinically, it is characterized by severe mucosal erosions and various cutaneous lesions associated with lymphoproliferative neoplasmas. Suprabasal acantholysis and clefts with scattered necrotic keratinocytes are the unique histopathological features. PNP patient sera recognize multiple antigens, which have been identified as the plakin protein family that includes desmoplakin, bullous pemphigoid antigen I (BPAG1), envoplakin and periplakin, and desmogleins 1 and 3. Castleman's tumor, non-Hodgkin's lymphoma, thymoma, follicular dendritic cell sarcoma and chronic lymphocytic leukemia are the commonly associated neoplasmas in PNP. We have also demonstrated that the autoantibodies reacting to epidermal proteins are directly produced by the cells in the associated tumors. Bronchiolitis obliterans is frequently found in PNP and may cause respiratory failure and death. In our experience, the early detection and removal of the tumor and i.v. administration of immunoglobulin are critical for the treatment of PNP.

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Section: Symptoms Of Respiratory System and Prognosismentioning

confidence: 80%

Paraneoplastic pemphigus

Zhu¹,

ZHANG²

2007

The Journal of Dermatology

130

114

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“…[50][51][52] However, few articles have been published about the effect of intravenous administration of immunoglobulin in the treatment of PNP. 51,53 In our study, the first 4 of the 10 patients did not accept intravenous administration of immunoglobulin, and 3 of them developed severe bronchiolitis obliterans within 1 week after the operation. However, in the other 6 patients, respiratory symptoms were controlled or prevented by giving immunoglobulin intravenously before and during the operation.…”

Section: Use Of Intravenous Immunoglobulin In Prevention Of Bronchiolmentioning

confidence: 99%

“…Intravenous administration of immunoglobulin also neutralizes pathogenic autoantibody and has a strong antiinflammatory effect depending on its interactions with the complement system, cytokines, and endothelial cells. [50][51][52] However, few articles have been published about the effect of intravenous administration of immunoglobulin in the treatment of PNP. 51,53 In our study, the first 4 of the 10 patients did not accept intravenous administration of immunoglobulin, and 3 of them developed severe bronchiolitis obliterans within 1 week after the operation.…”

Section: Use Of Intravenous Immunoglobulin In Prevention Of Bronchiolitis Obliteransmentioning

confidence: 99%

Paraneoplastic Pemphigus Associated With Castleman Tumor

Wang¹,

Zhu²,

Li³

et al. 2005

Arch Dermatol

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Background: Castleman tumor, a rare lymphoproliferative disorder, is one of the associated tumors in paraneoplastic pemphigus. We analyzed the characteristics of a group of patients with Castleman tumor to clearly understand and to improve the prognosis of the disease.Observations: Ten cases of paraneoplastic pemphigus associated with Castleman tumor treated in the Department of Dermatology, Peking University First Hospital, Beijing, China, from May 1, 1999, to March 31, 2004, were analyzed for clinical aspects, characteristics and histologic features of the tumors, and computed tomographic findings. Literature was reviewed and data were compared with our cases. Castleman tumor was a frequently reported neoplasm in association with paraneoplastic pemphigus in China. The disease was found to be caused by an autoimmune reaction originating from the B lymphocytes in the Castleman tumor.Conclusions: Castleman tumor in association with paraneoplastic pemphigus is a commonly reported subtype of paraneoplastic pemphigus in China. Early detection and removal of the Castleman tumor are crucial for the treatment of this tumor-associated autoimmune disease.

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Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins

2007

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Patients with immunodeficiencies or some types of autoimmune diseases rely on a safe therapy with intravenous immunoglobulins (IVIGs) manufactured from human plasma, the only available source for this therapeutic. Since plasma is predisposed to contamination by a variety of blood-borne pathogens, ascertaining and ensuring the pathogen safety of plasma-derived therapeutics is a priority among manufacturers. State-of-the-art manufacturing processes provide a high safety standard by incorporating virus elimination procedures into the manufacturing process. Based on their mechanism these procedures are grouped into three classes: partitioning, inactivation, and virusfiltration.

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Use of IGIV in the Treatment of Immune-Mediated Dermatologic Disorders

Cited by 5 publications

References 55 publications

Paraneoplastic pemphigus

Paraneoplastic pemphigus

Paraneoplastic Pemphigus Associated With Castleman Tumor

Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins

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