Use of I131 Labeled Oleic Acid in Study of Gastrointestinal Function.

Evaluation of Drainage Procedures Combined with Vagotomy

“…Radioactive triolein and oleic acid studies were carried out in an attempt to detect a deficiency of pancreatic lipase secretion after the operations. Malm et al (1956), Isley et al (1957) and Lubran (1963) have shown that when there is a deficiency of pancreatic lipase, oleic acid absorption is normal but triolein uptake is depressed. The three groups showed no significant difference.…”

Studies in Fat Absorption: Iii. The Radiotriolein and Radio‐oleic Acid Absorption Tests

“…The place of radio-oleic acid is established in the evaluation of pancreatic dysfunction as a cause of steatorrhcea (Isley et alii, 1957;Shingleton et alii, 1957;Reemtsma et alii, 1957;and Kaplan et alii, 1958). Our studies on patients with pancreatic steatorrhcea revealed normal blood and stool radioactivity levels with radio-oleic acid, and abnormal results with radiotriolein; subjects suffering from intestinal steatorrhcea, on the other hand, showed malabsorption of both substances.…”

Use of unabsorbed radioactive marker substances in a re-assessment of the radioactive triolein test of fat absorption

“…They suggested that after the oral administration of labelled fat an index ofabsorption could be obtained from a measurement of either the subsequent blood radioactivity curve or the amount of unabsorbed radioactivity in the faeces. After initial enthusiasm (Baylin, Sanders, Isley, Shingleton, Hymans, Johnston, and Ruffin, 1955;Ruffin, Shingleton, Baylin, Hymans, Isley, Sanders, and Sohmer, 1956;Ruffin, Keever, Chears, Shingleton, Baylin, Isley, and Sanders, 1958) the use of the blood curve has been rejected by most investigators because its peak and shape were shown to be influenced by factors other than that due to fat absorption (Isley, Sanders, Baylin, Sharpe, Hymans, Ruffin, Shingleton, and Wilson, 1957;Mohamed and Hume, 1959;and Vidinli, Texter, and Cooper, 1963). More recently, the use of the measurement of faecal radioactivity after oral administration of labelled fat has also fallen into disrepute, chiefly because several workers found inconsistent correlation with chemical faecal fat estimation (eg, Pimparkar, Tulsky, Kalser, and Bockus, 1960;Cox, 1961;Clark, Crooks, Dawson, and Mitchell, 1964).…”