Use of Andrographis paniculata (Burm. f.) Nees for Treating Hepatitis

Abstract

Andrographis paniculata (Burm. f.) Nees (APN) is a medicinal plant widely used in Asian countries. APN is used for its anti-inflammatory and antiviral properties. Previous studies did not clarify its pathway to treat hepatitis under the next generation of natural antibiotics. No definite trend has found expression in the multi-component Chinese medicine (MCCM). Besides, the research and development of a particular component in APN can not cover the most pharmacological effects of APN treating hepatitis. Based on the current information biology data, this review found that the intersection number of APN and hepatitis were 1,016 from 3,922 APN PPI targets and 1,818 hepatitis targets, respectively, according to current data. The filtered prediction outcome suggests that the MCCM of APN treating hepatitis were wogonin, oroxylin A, and andrographolide, which accounted for more than 95% of the compound contribution index of APN treating hepatitis. The predicated primary related pathways were the Notch, thyroid hormone, hepatitis B, and prolactin signalling pathways. This review serves to summarize the current research on APN to indicate a specific research direction to determine the pharmacological mechanism of APN and the interaction between drug targets and disease targets, laying a foundation for the subsequent development of its MCCM, new drugs, and auxiliary drugs.