Use of hyperbaric oxygen in hematopoietic cell transplantation to aid post-transplant recovery

Mina, Alain; Aljitawi, Omar S.

doi:10.2217/cer-2019-0193

Cited by 1 publication

(1 citation statement)

References 21 publications

(42 reference statements)

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“…However, researchers have been developing strategies to increase the number of hematopoietic stem cells in UC units either in vivo or ex vivo (11). Preclinical experiments demonstrated that hyperbaric oxygen (HBO) treatment before the HSCT could improve homing of HSC in vivo during the transplant process and speed up neutrophil and platelet engraftment, reducing the risk of infections and bleeding during the critical period early post-HSCT (12,13). The same technique can be applied in autologous hematopoietic stem cell transplant with the intent to improve engraftment and to decrease hospitalization length.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Unique patterns of lymphocyte recovery post-hematopoietic stem cell transplant associated with hyperbaric oxygen therapy: A case series

Elsayed¹,

Abdelhakim²,

Shune³

et al. 2022

Front. Hematol.

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The utilization of hematopoietic stem cell transplantation (HSCT) has been rapidly growing due to multiple factors, including better availability of donors and improved supportive care. Hyperbaric oxygen has been associated with the improvement of hematopoietic stem cell (HSC) homing at the time of transplant through lowering erythropoietin levels in preclinical studies. We studied the role of hyperbaric oxygen (HBO) in the enhancement of engraftment of HSC when utilized prior to umbilical cord HSCT and autologous HSCT in two pilot clinical trials with excellent safety profiles. In these two pilot studies, we observed an uncommon phenomenon post-transplant, particularly a significant peripheral blood lymphocytosis and lymphocyte infiltration of different tissues in 3/34 of HBO-treated patients. This peripheral blood lymphocyte expansion was associated with various clinical manifestations that can be confused with infections, inflammatory conditions, or disease relapse. We hypothesize that this observation is related to different immune reconstitution dynamics related to the use of HBO. While the incidence is ~9%, this may have implications as HBO is being investigated in larger clinical trials. This case series highlights the clinical presentation, course, outcome, and potential implications of this significant rise in lymphocytes when utilizing HBO before HSCT.

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Section: Introductionmentioning

confidence: 99%

Case Report: Unique patterns of lymphocyte recovery post-hematopoietic stem cell transplant associated with hyperbaric oxygen therapy: A case series

Elsayed¹,

Abdelhakim²,

Shune³

et al. 2022

Front. Hematol.

View full text Add to dashboard Cite

show abstract

Use of hyperbaric oxygen in hematopoietic cell transplantation to aid post-transplant recovery

Abstract: In this future pilot clinical trial concept patients will receive HBO therapy not only before stem cell infusion, but also afterward. In a separate approach, we are working on developing EPOR small-molecule inhibitors. "

Cited by 1 publication

References 21 publications

Case Report: Unique patterns of lymphocyte recovery post-hematopoietic stem cell transplant associated with hyperbaric oxygen therapy: A case series

Case Report: Unique patterns of lymphocyte recovery post-hematopoietic stem cell transplant associated with hyperbaric oxygen therapy: A case series

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