Use of human amniotic membrane in otolaryngologic practice

Zohar, Yuval; Yp, Talmi; Finkelstein, Yehuda; Y, Shvili; Sadov, Rima; Laurian, N.

doi:10.1288/00005537-198708000-00018

Cited by 46 publications

(24 citation statements)

References 9 publications

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“…It has been used to treat variable diseases such as non-healing skin ulcers, vaginal atresia, and severe ocular surface disease [9,35]. Moreover, it can serve as adjunctive tissue to reduce surgical adhesions in abdominal surgery and otolaryngologic surgery [25,29,36]. Furthermore, AM is an immuneprivileged tissue and rarely causes immunologic rejection [15].…”

Section: Introductionmentioning

confidence: 99%

Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions

Huang

Fan

2009

Eur Spine J

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Postlaminectomy epidural adhesion is implicated as a main cause of ''failed back surgery syndrome'' and associated with increased risk of complications during revision surgery. Various materials acting as mechanical barriers to reduce fibroblasts infiltration into epidural space have met with limited success. In present research, amniotic membrane (AM) was studied to investigate its effects on reducing epidural scar adhesion after laminectomy in a canine model. Laminectomy sites were created at L-1, L-3, L-5, and L-7 levels in 24 adult mongrel dogs. Freeze dried AM (FAM), cross-linked AM (CAM), and autologous free fat (AFF) were implanted, respectively, at a randomly assigned site in each dog with the remaining untreated site serving as internal control. The animals were sacrificed at 1, 6, and 12 weeks postoperatively. Then, gross pathologic observation including scar amount and adhesion tenacity, qualitative histology evaluation, and quantitative histology analysis were compared. Gross observation demonstrated that scar amount and adhesion tenacity of CAM group were significantly lower in comparison with those of FAM and non-treatment groups. A white, slightly vascularized CAM layer covered the dura mater without tenacious scar adhesion. The histology analysis also indicated reduced fibroblasts infiltration and consequent epidural fibrosis, which were similar to the results of AFF group. In conclusion, the CAM is effective in reducing epidural fibrosis and scar adhesion after laminectomy in canine model. It is a promising biomaterial for future clinical applications.

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Section: Introductionmentioning

confidence: 99%

Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions

Huang

Fan

2009

Eur Spine J

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“…Application of amniotic membrane has been carried out with satisfactory results on conjunctival defects reconstruction, ear reconstruction surgery, and vaginal epithelization. [17][18][19] Amniotic membrane has also been used to prevent adhesion in abdominal or pelvic surgery. 20,21 Another study showed that amniotic membrane induces down-regulation of transforming growth factor-beta (TGF-β), which has a role in the process of wound healing by triggering fibroblasts and macrophages recruitment and stimulates collagen production.…”

Section: 10mentioning

confidence: 99%

“…15,16 Amniotic membrane also gave satisfactory result on conjunctival defect reconstruction, ear reconstruction, vaginal epithelialization, and abdominal surgery. [17][18][19][20][21] The use of amniotic membrane on tendon repair has been developed in recent years. Bennett, et al 22 reported that amniotic membrane may reduce adhesion by suppressing the number of fibroblasts and macrophages in wound healing process.…”

Section: -25mentioning

confidence: 99%

Effect of lyophilized amniotic membrane, hyaluronic acid, and their combination in preventing adhesion after tendon repair in New Zealand white rabbits

Hadi

Sukmawan

2014

Med J Indones

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Abstrak AbstractBackground: Several promising methods to reduce the peritendinous adhesion after repair include amniotic membrane and hyaluronic acid application on the repaired tendon site. This study aimed to compare the effect of lyophilized amniotic membrane, application of hyaluronic acid, and their combination in preventing peritendinous adhesion after tendon repair in New Zealand white rabbits.Methods: 64 flexor digitorum fibularis tendon from 16 rabbits were cut and then repaired by modified Kessler technique. Samples were allocated into four test groups; group I as control had simple tendon repair, group II had amniotic membrane wrapping at repair site, group III had hyaluronic acid application at repair site, and group IV had combination of amniotic membrane wrapping and hyaluronic acid application. On 6 th week, 8 tendon from each group underwent macroscopic and histologic evaluation of peritendon adhesion by Tang scoring system. The rest of samples were evaluated for tendon gliding at tenth week by measuring active and passive range of motion of metatarsophalangeal joint.

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“…HAM has also been used to promote healing in corneal diseases such as chemical and thermal burns, neurotrophic ulcers, persistent epithelial defects, shield ulcers, microbial keratitis, band keratopathy and bullous keratopathy (Dua et al, 2004, Tosi et al, 2005a, Tosi et al, 2005b. Furthermore, the use of HAM as a biomaterial has not been confined to ophthalmologyit is also widely used in general surgery and wound treatment, e.g., for burned skin, bedsores, ulcers (Faulk et al, 1980), and in head and neck surgery (Zohar et al, 1987). More recently, HAM has been used as a culture substrate for ex vivo cultured LSC transplantation.…”

Section: Amniotic Membrane Transplantationmentioning

confidence: 99%