Use of human acellular dermal matrix for hernia repair: Friend or foe?

Candage, Raymond; Jones, Keith; Luchette, Fred A.; Sinacore, James; Vandevender, Darl; Reed, R. Lawrence

doi:10.1016/j.surg.2008.06.018

Cited by 133 publications

(70 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27 Furthermore, Candage et al describe wound-related complications in 54% of patients with multiple comorbidities; however, this includes grade-4 hernia patients with infected or contaminated wounds. 35 The current literature does not provide clear evidence regarding mesh selection for grade 2 or 3, intermediate-risk abdominal hernia patients. The senior author selected a biologic mesh to minimize complications in a patient population with multiple medical comorbidities given the likelihood of a failed prosthetic reconstruction; 78% of patients presented with a recurrent hernia and 12% already had an infected previous prosthetic mesh reconstruction.…”

Section: Discussionmentioning

confidence: 98%

Critical Analysis of Strattice Performance in Complex Abdominal Wall Reconstruction: Intermediate–Risk Patients and Early Complications

Patel

Albino

Nahabedian

et al. 2013

International Surgery

View full text Add to dashboard Cite

The purpose of this study was to analyze the performance of a porcine-derived acellular dermal matrix (Strattice Reconstructive Tissue Matrix) in patients at increased risk for perioperative complications. We reviewed medical records for patients with complex abdominal wall reconstruction (AWR) and Strattice underlay from 2007 to 2010. Intermediate-risk patients were defined as having multiple comorbidities without abdominal infection. Forty-one patients met the inclusion criteria (mean age, 60 years; mean body mass index, 35.5 kg/m2). Comorbidities included coronary artery disease (63.4%), diabetes mellitus (36.6%), and chronic obstructive pulmonary disease (17.1%). Fascial closure was achieved in 40 patients (97.6%). Average hospitalization was 6.4 days (range, 1–24 days). Complications included seroma (7.3%), wound dehiscence with Strattice exposure (4.9%), cellulitis (2.4%), and hematoma (2.4%). All patients achieved abdominal wall closure with no recurrent hernias or need for Strattice removal. Patients with multiple comorbidities at intermediate risk of postoperative complications can achieve successful, safe AWR with Strattice.

show abstract

Section: Discussionmentioning

confidence: 98%

Critical Analysis of Strattice Performance in Complex Abdominal Wall Reconstruction: Intermediate–Risk Patients and Early Complications

Patel

Albino

Nahabedian

et al. 2013

International Surgery

View full text Add to dashboard Cite

show abstract

“…8 Clinically, nonbiodegradable synthetic patches, such as polypropylene 9 , polyester, 10 and expanded poly(tetrafluoroethylene) (ePTFE) 11 , are associated with complications including seromas and fistula 12,13 , patient discomfort 14 , surgical site infections 12,15 , and limited physical activity of the patient due to poorer abdominal wall compliance 16 , whereas the weak mechanical properties, size limitation, and high cost of biological materials, such as acellular dermal matrix 17,18 and SIS 19,20 , limited their use. 21 A tissue engineering approach to hernia repair would be a promising alternative to meet current clinical needs through placing a biodegradable synthetic polymer-biological material blend patch at the abdominal wall site to provide temporary mechanical support and regenerate new abdominal muscles.…”

Section: Introductionmentioning

confidence: 99%

An Elastomeric Patch Electrospun from a Blended Solution of Dermal Extracellular Matrix and Biodegradable Polyurethane for Rat Abdominal Wall Repair

Hong

Takanari

Amoroso

et al. 2012

Tissue Engineering Part C: Methods

View full text Add to dashboard Cite

A biodegradable elastomeric scaffold was created by electrospinning a mixed solution of poly(ester urethane)urea (PEUU) and porcine dermal extracellular matrix (dECM) digest, with PEUU included to provide elasticity, flexibility, and mechanical support and dECM used to enhance bioactivity and biocompatibility. Micrographs and differential scanning calorimetry demonstrated partial miscibility between PEUU and dECM. With greater dECM content, scaffolds were found to possess lower breaking strains and suture retention strength, although initial modulus was greater with higher dECM concentrations. The hybrid scaffolds containing 0% to 50% dECM had tensile strengths of 5 to 7 MPa, breaking strains of 138% to 611%, initial moduli of 3 to 11 Mpa, and suture retention strengths of 35 to 59 MPa. When hydrated, scaffolds were found to contract markedly with 50% dECM content. When used in a rat full-thickness abdominal wall replacement model, no herniation, infection, or tissue adhesion was observed after 4 and 8 weeks with a scaffold containing 25% dECM or a control 100% PEUU scaffold. Scaffolds incorporating dECM were significantly thicker at the time of explant, with greater numbers of associated smooth muscle actin-positive staining cells than in the control, but minimal cellular infiltration and remodeling of the scaffold were detected regardless of dECM addition. The processing of dECM and PEUU from a mixed solution thus provided a scaffold with evidence of better bioactivity and with mechanical properties not achievable with digested dECM alone.

show abstract

“…Герніопластика з використанням алопласти-чних матеріалів вже є стандартом ведення хво-рих у багатьох країнах світу та широко застосо-вується завдяки кращій репарації післяоперацій-ної рани. Завдяки цьому спостерігається швид-кий розвиток та розробка різноманітних варіан-тів імплантатів [8][9][10], що значно утруднює вибір для клініцистів. На підставі проведеного аналізу літератури за останні 50 років Brown C.N.…”

Section: вступunclassified

Morphological changes of anterior abdominal wall tissues in rats after implantation of alloplastic material, processed with collagen.

Yeroshenko¹,

Fedoniuk²

2017

Morphologia

View full text Add to dashboard Cite

Use of human acellular dermal matrix for hernia repair: Friend or foe?

Cited by 133 publications

References 15 publications

Critical Analysis of Strattice Performance in Complex Abdominal Wall Reconstruction: Intermediate–Risk Patients and Early Complications

Critical Analysis of Strattice Performance in Complex Abdominal Wall Reconstruction: Intermediate–Risk Patients and Early Complications

An Elastomeric Patch Electrospun from a Blended Solution of Dermal Extracellular Matrix and Biodegradable Polyurethane for Rat Abdominal Wall Repair

Morphological changes of anterior abdominal wall tissues in rats after implantation of alloplastic material, processed with collagen.

Contact Info

Product

Resources

About