Use of HPLC with inductively coupled plasma mass spectrometry (ICP-MS) for trace element speciation studies in biological materials

Owen, Linda; Rauscher, Anne; Fairweather‐Tait, Susan J.; Crews, Helen M.

doi:10.1042/bst0240947

Cited by 9 publications

(1 citation statement)

References 2 publications

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“…with the aim to find specific biomarkers for copper and zinc status. A clinical case of a child with high levels of plasma zinc concentration but presenting signs of severe zinc deficiency was investigated by SEC-ICP-MS following administration of an oral dose of 67 Zn and an intravenous dose of 70 Zn (Owen et al, 1996). The analysis showed that most of the child endogenous and exogenous ( 67 Zn and 70 Zn) Zn was not associated with normal Zn-binding proteins but seemed to bind to a unconventional high molecular weight protein.…”

Section: Ros Production ↓mentioning

confidence: 99%

Micronutrient (Zn, Cu, Fe)–gene interactions in ageing and inflammatory age-related diseases: Implications for treatments

Mocchegiani

Costarelli

Giacconi

et al. 2012

Ageing Research Reviews

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In ageing, alterations in inflammatory/immune response and antioxidant capacity lead to increased susceptibility to diseases and loss of mobility and agility. Various essential micronutrients in the diet are involved in age-altered biological functions. Micronutrients (zinc, copper, iron) play a pivotal role either in maintaining and reinforcing the immune and antioxidant performances or in affecting the complex network of genes (nutrigenomic approach) involved in encoding proteins for a correct inflammatory/immune response. By the other side, the genetic inter-individual variability may affect the absorption and uptake of the micronutrients (nutrigenetic approach) with subsequent altered effects on inflammatory/immune response and antioxidant activity. Therefore, the individual micronutrient-gene interactions are fundamental to achieve healthy ageing. In this review, we report and discuss the role of micronutrients (Zn, Cu, Fe)-gene interactions in relation to the inflammatory status and the possibility of a supplement in the event of a micronutrient deficiency or chelation in presence of micronutrient overload in relation to specific polymorphisms of inflammatory proteins or proteins related of the delivery of the micronutriemts to various organs and tissues. In this last context, we report the protein-metal speciation analysis in order to have, coupled with micronutrient-gene interactions, a more complete picture of the individual need in micronutrient supplementation or chelation to achieve healthy ageing and longevity.

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Section: Ros Production ↓mentioning

confidence: 99%