Use of Honey Versus Standard Care for Hospital-Acquired Pressure Injury in Critically Ill Children: A Multicenter Randomized Controlled Trial

Sankar, Jhuma; Lalitha, A V; Rameshkumar, Ramachandran; Mahadevan, Subramanian; Kabra, Sushil Kumar; Lodha, Rakesh

doi:10.1097/pcc.0000000000002611

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…Moreover, the high viscosity of honey provides a protective barrier preventing infection [ 7 ]. Finally, yet importantly, honey has antimicrobial effects based on a multitude of factors diminishing the bioburden of wounds [ 3 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Honey had been used to treat wounds for thousands of years in multiple cultures. It was recorded in an Egyptian surgical text traced back to between 2600 and 2200 BCE [ 9 , 10 ]. In the modern medicine, successful results have been achieved after honey application to many wounds, such as burns, different chronic ulcers, infected surgical wounds, malignant wounds, Fournier’s gangrene and neonatal wounds, along with others [ 4 , 5 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Honey dressing: a missed way for orthopaedic wound care

Ahmed

Eltregy

Kandil

2022

International Orthopaedics (SICOT)

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Purpose Orthopaedic-related wounds are critical situations calling for care to avoid deep infections and its consequences. The purpose of this study was to evaluate the efficacy of using honey for care of orthopaedic-related wounds with limited resources. Patients and methods This prospective study included 50 cases with an average age of 38.18 (range 17–63) years with 38 males and 12 females. The most frequent wound location was the leg (41 patients; 82%), then the foot (six patients; 12%), and the ankle in three patients (6%). The aetiologies were open fractures (34 cases; 68%), infected tibial non-unions (nine cases; 18%), and post-operative infections (seven cases; 14%). Exposed tendon was present in three cases. Bone exposure was present in two cases. Deep infection was present in 29 cases (58%). Besides treating the primary cause, a ribbon of gauze soaked with honey was applied to the wounds after thorough saline washing. Results Wound sizes were variable. All cases showed improvement in all parameters with complete wound healing and full coverage of bone and tendons. Recurrence of deep infection occurred in three cases and treated by debridement. One case needed sequestrectomy of a small exposed tibial cortical fragment. Exposed tendon cases showed superficial necrosis which was treated by simple debridement. Initial mild itching occurred in five patients with spontaneous resolution. Conclusion With treating the underlying aetiology and optimising the patient’s general condition, honey was an effective, simple, and affordable method of wound care in different orthopaedic conditions even with exposed bone or tendons.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Honey dressing: a missed way for orthopaedic wound care

Ahmed

Eltregy

Kandil

2022

International Orthopaedics (SICOT)

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“…However, it was of interest that there was a greater proportion of adverse events observed in the conventional treatment, compared to the intervention groups combined [ 105 ]. Another trial listed (trial registration NCT03391310) documented the results in a publication, demonstrating the reduced wound healing time with the treatment of Manuka honey dressing/gel compared to the standard treatment [ 104 , 106 ]. This study consisted of 99 participants, randomised into the honey or standard care group, with no adverse events recorded in the honey treatment group [ 106 ].…”

Section: Bioactive Small Molecules From Natural Sources With Promisin...mentioning

confidence: 99%

“…Another trial listed (trial registration NCT03391310) documented the results in a publication, demonstrating the reduced wound healing time with the treatment of Manuka honey dressing/gel compared to the standard treatment [ 104 , 106 ]. This study consisted of 99 participants, randomised into the honey or standard care group, with no adverse events recorded in the honey treatment group [ 106 ]. Both trials demonstrated the enhanced wound-healing capability of Manuka honey wound dressings compared to the conventional treatment, indicating their potential to be used as first-line wound care treatment.…”

Section: Bioactive Small Molecules From Natural Sources With Promisin...mentioning

confidence: 99%

Evidence for Natural Products as Alternative Wound-Healing Therapies

et al. 2023

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Chronic, non-healing wounds represent a significant area of unmet medical need and are a growing problem for healthcare systems around the world. They affect the quality of life for patients and are an economic burden, being difficult and time consuming to treat. They are an escalating problem across the developed world due to the increasing incidence of diabetes and the higher prevalence of ageing populations. Effective treatment options are currently lacking, and in some cases chronic wounds can persist for years. Some traditional medicines are believed to contain bioactive small molecules that induce the healing of chronic wounds by reducing excessive inflammation, thereby allowing re-epithelisation to occur. Furthermore, many small molecules found in plants are known to have antibacterial properties and, although they lack the therapeutic selectivity of antibiotics, they are certainly capable of acting as topical antiseptics when applied to infected wounds. As these molecules act through mechanisms of action distinct from those of clinically used antibiotics, they are often active against antibiotic resistant bacteria. Although there are numerous studies highlighting the effects of naturally occurring small molecules in wound-healing assays in vitro, only evidence from well conducted clinical trials can allow these molecules or the remedies that contain them to progress to the clinic. With this in mind, we review wound-healing natural remedies that have entered clinical trials over a twenty-year period to the present. We examine the bioactive small molecules likely to be in involved and, where possible, their mechanisms of action.

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“…Pressure injury is a surgical disorder resulting in tissue ulceration and necrosis due to long-term local tissue pressure followed by persistent ischemia, hypoxia, and malnutrition. [1][2][3] Modern medicine considers pressure injuries as chronic, difficult-to-heal wounds, which are characterized by a lack of microvascular count and repair factors, tissue hypoxemia, and delayed epithelialization. [4] Would healing will be difficult following pressure injuries.…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of moxibustion for pressure injury

Xiang¹,

Jiang²,

Hu³

et al. 2022

Medicine

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Background: Pressure injury is an important global health issue characterized by the high incidence, rapid progression, and difficult healing. How to perform timely treatment and care have been the current focus and challenge for health care professionals. Moxibustion can improve skin microcirculation, promote blood circulation, activate tissue cells, inhibit, and kill bacteria on the wounded surface, thus promoting wound healing. However, the clinically reported efficacy of moxibustion in the treatment of pressure injuries varies a lot and lacks evidence-based medical evidence. Therefore, this meta-analysis aims to evaluate the efficacy and safety of moxibustion on the treatment of pressure injuries.Methods: Randomized controlled trials (RCTs) reporting the moxibustion for pressure injury published before January 2022 will be searched in online databases, including the Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, Wanfang Database, China Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web of Science. References of eligible literatures will be manually reviewed. According to inclusion and exclusion criteria, literature screening, data extraction and quality assessment will be independently performed by 2 reviewers, and meta-analysis of relevant data will be conducted using Stata14.0 software. Results:The study will provide a high-quality convincing assessment of efficacy and safety of moxibustion for pressure injury. Conclusion:The results of this study will provide the latest evidence support for judging the efficacy and safety of moxibustion on the treatment of pressure injury.

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Use of Honey Versus Standard Care for Hospital-Acquired Pressure Injury in Critically Ill Children: A Multicenter Randomized Controlled Trial

Abstract: To examine if the use of honey (medicated) for dressing is superior to standard care in terms of time to complete wound healing in stages 1-3 of pressure injuries in children admitted to the PICU.

Cited by 7 publications

References 41 publications

Honey dressing: a missed way for orthopaedic wound care

Honey dressing: a missed way for orthopaedic wound care

Evidence for Natural Products as Alternative Wound-Healing Therapies

The efficacy and safety of moxibustion for pressure injury

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